Session 3- Resorption of sodium along the tubule Flashcards
What is tthe renal threshold for resorption of glucose
10mmol/ml
What is normal plasma glucose concentration
2.5-5.5 mmol/L
How much glucose is filtered per minute
0.2-0.5 mmol
Where is glucose reabsorbed and where
PCT and all
How is glucose reabsorbed
Secondary active transport driven by energy released from transport of Na+ down its concentration gradient
What is Tm
The maximum tubular resorptive capacity of a solute
What develops of plasma glucose rises above 10mmol/L
Glyccosuria- sugar in urine
Why does glycosuria develop in pregnancy
As the Tm for glucose falls and glucose is excreted in the urine
Where and how are amino acids reabsorbed
Proximal convulsed tubule by secondary active transport
-symport with Na+ driven by Na+/K + ATPase as with glucose
How do AA’s move through the glomerulus
Easily them are reabsored in PCT
How is sodium reabsorbed in the PCT
Basolateral 3Na-2K-ATPase
How is sodium reabsorbed apically
- Na H exchange
- Co-transport with glucose
- Co-transport with AA or carboxylic acids
- Co-transport with phosphate (NaPi channel sensitive to [↑PTH])
Hw does the conc gradient change from cortex to papilla
Increase
What is central diabetes insipidus
Impaired ADH synthesis or secretion by the hypothalamus. Damage to hypothalamus or pituitary glad due to-
- brain injury
- tumour
- sarcoidosis or tuberculosis
- an aneurysm
- encephalitis or meningitis
How do you treat diabetes insipidus
Administering ADH - desmopressin
