GIT Assessment

Question 1

There they undergo conversion to compounds that IRREVERSIBLY INACTIVATE the parietal cell H+/K+ ATPase, the transporter that is primarily responsible for producing stomach acid.

Answer 1

Omeprazol

Question 2

Act selectively on H2 receptors in the stomach, blood vessels, and other sites, but they have no effect on H1 receptors. They are competitive antagonists of histamine and are FULLY REVERSIBLE.
These agents completely inhibit gastric acid secretion induced by histamine or gastrin.

Answer 2

Cimetidine, Ranitidine

Question 3

Inhibit both basal and stimulated gastric acid secretion by more than 90 percent.

Answer 3

PPI (Omeprazol)

Question 4

Adverse effect are diarrhea, abdominal pain, and headache. Chronic treatment may result in hypergastrinemia. They decrease the oral bioavailability of vitamin B12 and certain drugs that require acidity for their gastrointestinal absorption.

Answer 4

PPI Omeprazole

Question 5

Treatment for GERD and peptic ulcer and equally effective in the treatment of nonulcer dyspepsia and the prevention of stress-related mucosal bleeding.
They are also useful in the treatment of Zollinger-Ellison syndrome.

Answer 5

PPI Omeprazol

Question 6

The prototype histamine H2-receptor antagonist
and its utility however is limited by its adverse effect profile and drug interactions

Answer 6

Cimetidine

Question 7

Therapeutic use of Cimetidine and Ranitidine

Answer 7

Peptic Ulcer, Acute Stress Ulcer, GERD

Question 8

Drug causes gynecomastia,
galactorrhea (continuous release/discharge of milk),
reduced sperm count

Answer 8

Cimetidine

Question 9

Are used for symptomatic relief of peptic ulcer disease and GERD

Answer 9

Aluminum- and magnesium-containing antacids

Question 10

Adverse effect:
Aluminum hydroxide:

Magnesium hydroxide:

Answer 10

Aluminum hydroxide: constipation

Magnesium hydroxide: diarrhea

Question 11

Is readily absorbed from the small intestine whereas absorption from the colon is extremely low.

Answer 11

5ASA/ Mesalamin

Question 12

May involve inhibiting the synthesis of prostaglandins and inflammatory leukotrienes, and interfering with the production of inflammatory cytokines. Use for IBD

Answer 12

Mesalamine

Question 13

These drugs can be administered as a single dose prior to chemotherapy (intravenously or orally) and are efficacious against all grades of emetogenic therapy.

Answer 13

Ondansetron