25 & 26 - Blood Typing and Transfusions

Question 1

H substance

Answer 1

protein acted on by ABO gene products to make A and B antigens (O makes a serum protein w/ no known fn/activity)

Question 2

what antibodies do type O people have?

Answer 2

Anti-A (IgM), Anti-B (IgM), Anti-A,B (IgG - can cross placenta!)

Question 3

front and back typing for ABO groups

Answer 3

front - determine Ags on RBCs

back - determine Abs in serum

Question 4

main Rh antigen

Answer 4

D

Question 5

how much blood is donated at a time?

Answer 5

450 ml ish + 30 ml for testing

Question 6

what is the shelf life of RBCs in additive solution 1?

Answer 6

42 d

Question 7

how much will a unit of RBCs inc Hgb and Hct in adult?

Answer 7

1 g/dL and 2-3%

Question 8

Hbg threshold for transfusing RBCs (nl and heart/lung dz)

Answer 8

nl - 7-8 g/dL

heart/lung dz - 10 g/dL

Question 9

function of FFP

Answer 9

replenish coag factors - NOT volume expansion

ex: TTP, warfarin OD

Question 10

how much will one unit of platelets inc ct?

Answer 10

5,000/uL

Question 11

are platelet transfusions indicated for ITP, TTP, or HIT?

Answer 11

no (except in ITP if there is significant bleeding)

Question 12

what is cryoprecipitate and what is it used for?

Answer 12

thaw FFP and collect precip (fibrinogen, F.VIII, F.XIII, vWF, fibronectin)

used for low fibrinogen. can also be source of vWF and F.XIII

Question 13

criteria for Rh neg people RBC transfusions

Answer 13

Rh neg female of childbearing age = always Rh neg
Rh neg people >50 yo = can have Rh pos
Rh pos people - doesnt matter
*also applies to platelets!!