27 - Path of Vasculitis

Question 1

2 types of large vessel vasculitis

Answer 1

giant cell arteritis

takayasu arteritis

Question 2

2 types of medium vessel vasculitis

Answer 2

polyarteritis nodosa

kawasaki disease

Question 3

giant cell arteritis - type/location of inflammation

Answer 3

granulomatous inflammation at jxn of tunica intima and tunica media

Question 4

giant cell arteritis - age and assoc condition

Answer 4

old

polymyalgia rheumatica

Question 5

medical emergency assoc w/ giant cell arteritis

Answer 5

blindness due to occlusion of ophthalmic artery

Question 6

tx for giant cell arteritis

Answer 6

corticosteroids (immediately!)

Question 7

demographic for takayasu arteritis

Answer 7

young women

Question 8

takayasu’s arteritis - type/location of inflammation

Answer 8

granulomatous inflammation involving jxn btwn adventitia and media

Question 9

clinical presentation of takayasu arteritis

Answer 9

weakened UE pulses and ocular disturbances

Question 10

polyarteritis nodosa - type/location of inflammation

Answer 10

systemic transmural inflammation in muscular arterioles, can cause aneurysms

Question 11

what other condition is polyarteritis nodosa assoc w/?

Answer 11

chronic hep B

Question 12

sx of kawasaki disease

Answer 12

erythma of lips, hands, feet, desquamation of skin, LAN, vasculitis

Question 13

major consequence of kawasaki dz

Answer 13

heart dz / coronary aneurysm / MI

Question 14

mechanism for kawasaki dz

Answer 14

delayed hypersensitivity reaction

Question 15

tx of kawasaki dz

Answer 15

IVIG, aspirin

Question 16

what is ANCA?

Answer 16

anti neutrophil cytoplasmic antibodies

Question 17

wegener’s granulomatosis - type/location of inflammation

Answer 17

necrotizing vasculitis / granulomas in pulm (lower and upper resp tract) and renal vasculature

Question 18

wegener’s is assoc w/ what molecule?

Answer 18

C-ANCA (PR3-ANCA)

Question 19

churg strauss - type/location of inflammation

Answer 19

allergic granulomatosis and angiitis

necrotizing vasculitis w/ eosinophil infiltrate

Question 20

sx/manifestations of churg strauss

Answer 20

asthma, allergic rhinitis, lung infiltrates, peripheral eosinophilia, coronary arteritis/myocarditis

Question 21

what molecule is assoc w/ churg strauss?

Answer 21

P-ANCA (MPO-ANCA)

Question 22

microscopic polyangiitis - type/location of inflammation

Answer 22

necrotizing vasculitis of small vessels
can be started by reaction to drug
can be in microvasculature of kidney, lung, skin, mucus membranes, brain, GI, heart

Question 23

what molecule is assoc w/ microscopic polyangiitis

Answer 23

P-ANCA (MPO-ANCA)

Question 24

thromboangiitis obliterans (buerger’s disease) typical history

Answer 24

young male heavy smoker

Question 25

thromboangiitis obliterans - type/location of inflammation

Answer 25

segmental thrombosing vasculitis of small to med arteries of extremities

Question 26

hemangioendothelioma

Answer 26

in between benign and malignant
occurs in med to large veins
most cured by excision, but 40% recur and 20-30% eventually metastasize

Question 27

lymphedema after radical mastectomy can predispose pt to

Answer 27

angiosarcoma