Anti epileptic Drugs

Question 1

What are three mode of action epileptic drugs

Answer 1

Enhance GABA mediated synaptic inhibition so increase GABA action

Reduce cell membrane electrical excitability so inhibit sodium channel

Inhibit T type calcium channel

Question 2

Name the antiepileptic drugs

Answer 2

Sodium valproate

Phenytoin carbamazepine phenobarbital ethosuximide Vigabatrin Lamotrigine topiramate clobazam levetiracetam gabapentin

Question 3

How carbamazepine get Metabolize

Answer 3

Metabolize in liver

Question 4

What will induce by carbamazepine

Answer 4

CYP - 450 inducer

Question 5

What is contra indication in carbamazepine when used in seizures

Answer 5

Not used in absent seizures

Question 6

Where carbamazepine used as first line therapy

Answer 6

Trigeminal neuralgia

Question 7

Where carbamazepine is not recommended

Answer 7

Primary generalized seizures in myoclonic seizures

Question 8

What are the side effects of the carbamazepine

Answer 8

Ataxia dizziness diplopia blurred vision drowsiness depression of cardiac atrioventricular conduction rashes Steven Johnson syndrome osteomalacia folic acid deficiency hyponatremia GIT symptoms liver and thyroid dysfunction

Question 9

Where phenytoin get hydroxylated

Answer 9

Liver

Question 10

In phenytoin what will happen in low dose

Answer 10

First-order kinetics

Question 11

When phenytoin get therapeutic plasma concentration what is the kinetic type

Answer 11

Zero order kinetics

Question 12

What are the side effects of phenytoin

Answer 12

Megaloblastic anemia
 peripheral neuropathy 
ataxia 
Tremors 
vertigo  
hirsutism 
acne
 gum hyperplasia
 osteomalacia
Depuytren  contractures

Question 13

What is the action of the sodium valproate

Answer 13

Act sodium and calcium channels andGABA a receptors

Question 14

Where is sodium valproate metabolize

Answer 14

Liver

Question 15

Sodium valproate act on where?

Answer 15

Sodium/calcium channels and GABA a receptors

Question 16

Sodium valproate metabolized in?

Answer 16

Liver

Question 17

For what seizures use Na valproate

Answer 17

Absence seizures & other types

Question 18

What will prevented by Na valproate

Answer 18

Migraine and mania

Question 19

What are the side effects of sodium valproate

Answer 19

Weight gain, loss of hair, pros, hepatotoxicity, teratogenicity, gastric irritation. Pancreatitis, coagulation disorders.

Question 20

What is MOA of phenobarbital?

Answer 20

GABA receptor activation potent

Question 21

What’s type of inducer

Answer 21

Cyp-450 inducers

Question 22

Name the cyp-450 inducers

Answer 22

Carbemazepine/phenobarbital

Question 23

What’s cyp-450 inhibitor

Answer 23

Sodium valproate

Question 24

What’s action of ethosuximide?

Answer 24

Block T type calcium channels in thalamus neurons of absence seizures

Question 25

Comment on phenobarbital plasma 1/2 life

Answer 25

It has long 1/2 life

Question 26

What are side effects of phenobarbital?

Answer 26

Sedation, hepatitis, cholestasis, lethargy, hyperactivity, behavioral changes

Question 27

Ethoxugimide exaggerate?

Answer 27

Tonic clonic seizures

Question 28

Comment the ethosuximide t12?

Answer 28

Long TYT

Question 29

What are ses of ethosuximide?

Answer 29

Nausea/anorexia/headache

Question 30

Action of topiramate

Answer 30

Blockade of voltage gated sodium channels
Enhance GABa action
AMPA receptors blockade

Question 31

What are side effects of the topiramate

Answer 31

Sedation weight loss dyspepsia fatigue cognitive impairment

Question 32

What is the action of levetiracetam

Answer 32

Bind to protein synaptic vesicle protein 2A

Then inhibit the neurotransmitter release