Session 8- The placenta Flashcards

1
Q

when does the placenta begin to develop

A

second week of development

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2
Q

what develops from the outer cell mass

A

syncytiotrophoblast

cytotrophoblast

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3
Q

what develops from the inner cell mass

A

epiblast

hypoblast

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4
Q

what is the inner cell mass

A

embryoblast

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5
Q

what is the outer cell mass

A

trophoblast

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6
Q

how do the embryonic sacs change

A

yolk sac disappears
amniotic sac enlarges
chorionic sac is occupied by the expanding amniotic sac

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7
Q

what does implanation acheive

A

basic unit of exchange
anchor placenta
establish maternal blood flow within the placenta

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8
Q

how is the basic unit of exhange established

A

primary vili- early finger like prjections of trophoblast

secondary villi- invasion of mesenchyme into core

tertiary villi- invasion of mesenchyme core by fetal vessels

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9
Q

what happens to the placental membrane as the needs of the fetus increase

A

becomes progressively thinner to optimise transport

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10
Q

what does the placenta develop from

A

projections around the outer surface of the membrane

balanced over the entire surface
as growth occurs the projections are concentrated into a single disc-like space which goes onto become the placenta

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11
Q

what is the decidua

A

the cells of the endometrium that become speacilized to modulate the degree of invasion of the conceptus once it has implanted through decidualisation

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12
Q

what happens if the conceptus implants in an area where there is no decidua

A

there is no inhibition of decidualisation and therefore no control ober extent of invasion

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13
Q

what happens if the implantation occurs in the correct place but the decidual reaction is suboptimal

A

range of complications where the pregancy is either nor maintaied or spectrum of placenal insufficiency inclduing pre-eclampsia

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14
Q

how are waste products taken from the fetus

A

through paired umbilical arteries through the villi

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15
Q

how are waste products taken from the fetus

A

through paired umbilical arteries through the villi

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16
Q

how is oxygen and nutrienys taken to the fetus

A

umbilical vein

17
Q

what sustains the corpus luteum in the first trimester

A

hCG

18
Q

what takes over from the corpus luteum

A

the placenta produces steriod hormones so that when sufficiently large it takes on the role of the corpus lutrum after the fist triester and produces enough progesterone and oestrogen to keep the HPG axis in the pregnant state

19
Q

how do placental hormonea affect maternal metabolism

A

progesterone promotes an increase in appetote to allow an increased fat depostion to hep support the fetuw and breastfeeding

20
Q

what does hPL do

A

help maintain a diabetogenic state to caus einsulin resistance in the mother increasing the glucose availibility to the fetus

21
Q

what immunoglobulins can cross the olacenta

A

IgG

22
Q

what are teratogens

A

something that can cause birth defects or abnormalities in a developing embryo or fetus upon exposure. Teratogens include some medications, recreational drugs, tobacco products, chemicals, alcohol, certain infections, and in some cases, health problems such as uncontrolled diabetes in pregnant people.

23
Q

when do teratogens have the greatest effect

A

embryonic state as this is a key time for devlpment

weeks 3-8

24
Q

by what process is immunoglobin trasnported across the placenta

A

receptor mediated endocytosis

25
Q

what are the cellular layers presenting a barrier to transfer between maternal and fetal circulations in the first trimester

A

cytotrophoblast, syncytiotrophoblast fetal capillary endothelium

26
Q

what are the cellular layers presenting a barrier to transfer between maternal and fetal circulations in the third trimester

A

syncitiotrophoblast and fetal capillary membrane

27
Q

how soon after fertilisation can hCG be detected in URINE

A

2 weeks

28
Q

how long does it take for hCG to be detected in SERUM

A

7 days