EXTRACELLULAR ACCUMULATIONS (MESENCHYMAL DEGENERATIONS)

Question 1

What are mesenchymal degenerations?

Answer 1

Extracellular accumulations

Question 2

Why do mesenchymal degenerations develop?

Answer 2

Mesenchymal (stromal vascular) degenerations develop in the connective tissue as a result of metabolic disturbances in it.

Question 3

What are the four types of proteinous mesenchymal degenerations?

Answer 3

Proteinous mesenchymal degenerations occur as mucoid swelling, fibrinoid changes, hyalinosis and amyloidosis.

Question 4

Which stages of proteinous mesenchymal degenerations

Answer 4

Mucoid swelling, fibrinoid changes, hyalinosis

Question 5

What are the causes of mucoid swelling, fibrinous changes and hyalinosis?

Answer 5

The causes of mucoid swelling, fibrinous changes and hyalinosis are the same as they are the stages of one process. They are immunopathological and autoimmune states, hypoxia, infections.

Question 6

In what conditions are proteinous mesenchymal degenerations common?

Answer 6

These types of connective tissue disorganization are frequently observed in hypertension, rheumatism and other diseases of the connective tissue accompanied by immune disturbances as well as in allergic diseases, diabetes mellitus

Question 7

Which tissues are involved in the majority of cases of mesenchymal degenerations?

Answer 7

In the majority of cases the arterial walls, heart valves, endocardium, epicardium, articular connective tissue are involved.

Question 8

What is mucoid swelling?

Answer 8

• Mucoid swellingis superficial reversible disorganization ofthe connective tissue.
• These processes are associated with swelling of collagen fibers, increased vascular permeability (due to glucosaminoglycans (GAG) action) and plasmorrhagia.