Allergies

Question 1

Hypersensitivity

Answer 1

an inappropriate immune response leading to tissue damage and other symptoms

Question 2

Type I Hypersensitivity reactions mediated by -

Answer 2

IgE

Question 3

Type II & III Hypersensitivity reactions mediated by -

Answer 3

IgG

Question 4

Type IV Type I Hypersensitivity reactions mediated by -

Answer 4

T cells

Question 5

Hygiene Hypothesis

Answer 5

More exposure to pathogens → immunity

Question 6

Genetic susceptibility

Answer 6

Polymorphisms in IL4 & HLA

Question 7

Type I-III are _____ mediated

Answer 7

ANTIBODY

Question 8

ANAPHYLAXIS

Answer 8

systemic reaction in response to an allergen introduced directly into the bloodstream

Question 9

outline a T1 hypersensitivity reaction

Answer 9

Pre-phase SENSITISATION
Allergen inhaled
Dendritic cells process & antigen presentation in lymph nodes
IgE binds FcR on mast cells & basophils
Subsequent exposure to antigen cross-links IgE - mast cell degranulation - INFLAMAMTION

MAST CELL becomes a loaded gun

Question 10

Clinical effects of mast cell degranulation

Answer 10

Food allergies
allergic rhinitis
bronchial asthma
anaphylaxis

Question 11

Preformed type I mediators

Answer 11

HISTAMINE
heparin
TNFa