Antituberculosis agents

Question 1

what causes tuberculosis

Answer 1

mycobacterium

Question 2

are Isoniazid (INH), ethambutol, pyrazinamide (PZA), rifampin, streptomycin first line or second line?

Answer 2

first line antituberculosis agents

Question 3

are Capreomycin, cycloserine, ethionamide, kanamycin, para-aminosalicylic acid (PAS) first line or second line?

Answer 3

2nd

Question 4

drug of choice for TB. Metabolized in the liver through acetylation (watch for slow acetylators-accumulation of the drug. Leads to a longer half life). Used alone or in combination with other agents

Answer 4

Isoniazid

Question 5

Side effects of Isoniazid

Answer 5

peripheral neuritis, hepatotoxicity

Question 6

Effectiveness depends on: type of infection, adequate dosing, sufficient duration of treatment, selection of effective drug combination

Answer 6

Antituberculosis Therapy

Question 7

side effects of Antituberculosis Therapy

Answer 7

Fatigue, N & V, numbness/tingling of extremities, fever, loss of appetite, depression, jaundice neuritis, blindness (ethambutol), discoloration of urine and stools (reddish orange), hepatitis (rifampin)