Skin Flashcards
1
Q
Ipx to distinguish between skin primary neoplasm vs metastasis to skin
A
skin tumour cells express CK5/6, p63, D2-40
if not then it is likely a metastasis.
2
Q
IPx to confirm Mycosis Fungoides
A
CD4 positive and CD8 negative or positive epidermotropic lymphocytes.
Large cell transformation - CD3 positive in large tumour cells. CD30 positivity often in large cells but not required for diagnosis. Large tumor cells are also often CD25(+)
