Angiogenesis Quiz

Question 1

Fill in the gaps:

Blood vessel growth is induced by production of __1__, discovered by Napoleone Ferrara in 1989, which is the same protein a VPF discovered by __2__’s group.

Answer 1

1: VEGF
2: Hal Dvorak’s

Question 2

Fill in the gaps:

VEGF acts on __1__ to induce increased intracellular __2__, release of __3__, __4__ withdrawal, and endothelial __5__.

Answer 2

1: VEGFR2
2: calcium
3: proteases
4: pericyte
5: migration

Question 3

Hypoxia increases VEGF protein by….

Answer 3

Increasing VEGF mRNA expression

Question 4

Place the processes in the right order:

Sprout fusion
increased intracellular calcium
hypoxia
VEGF production
matrix metalloproteinase production
increased vascular permeability
VEGFR2 activation
sprouting
migration
proliferation

Answer 4

1. Hypoxia
2. VEGF production
3. VEGFR2 activation
4. Increased intracellular calcium
5. Increased vascular permeability
6. Matrix metalloproteinase production
7. Sprouting
8. Migration
9. Proliferation
10. Sprout fusion

Question 5

Which of the following statements are true?

A) Ramucirumab is an antibody to VEGFR
B) Anti-VEGF antibodies are more effective when combined with chemotherapy than by themselves
C) Bevacizumab is a monoclonal antibody to VEGF-A
D) VEGF inhibitors are equally ineffective in all cancers
E) Pazopanib is a VEGFR tyrosine kinase inhibitor

Answer 5

A, B, C, and E are all true