Phenytoin Flashcards
1
Q
Class of phenytoin
A
Block Anti-convulsant
2
Q
How does phenytoin reduce hyperexcitability (channel it blocks)
A
Blocks v-gated Na channel —> — Na influx —> stabilise memb
3
Q
Phenytoin’s property to limit the spread of seizures makes it a good use if indicated in
A
Epilepsy
4
Q
What seizure does NOT use phenytoin
A
Absence
5
Q
Contraindications for phenytoin
A
Asian heritage
6
Q
PHENYTOIN side effects
A
- P450 interaction
- hirsutism
- enlarged gums
- nystagmus
- yellow-browning skin
- tetratogenic
- osteomalacia
- interferes w/ folate metabolism
- neuropathies
7
Q
What is the P450 interaction of phenytoin
A
- P450 inducer
- narrow therapeutic window
