Epithelium vocab Flashcards

1
Q

Functions of epithelia

A
  1. protect underlying tissues
  2. provide selective barrier between a lumen and underlying tissue
  3. synthesize substances like hormones, saliva for secretion
  4. transport substances by endo- and exocytosis
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2
Q

Characteristics of epithelia

A
  1. composed of continuous sheets of cells
  2. have specialized cell junctions
  3. are polarized
  4. are avascular
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3
Q

squamous

A

long, flat, much wider than tall

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4
Q

cuboidal

A

roughly even width and height

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5
Q

columnar

A

taller than wide

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6
Q

simple

A

one layer of cells only

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7
Q

stratified

A

have more than one layer of cells- one contacting basement membrane, one on free surface, maybe some layers in between

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8
Q

pseudostratified

A

appear stratified but are not; all cells contact basement membrane but not all reach apical surface; nuclei found at two levels

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9
Q

goblet cells

A

unicellular exocrine glands that secrete mucus onto a free surface; found in simple or pseudostratified epithelia

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10
Q

endothelium

A

simple squamous epithelium that lines the heart and all blood and lymphatic vessels

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11
Q

mesothelium

A

simple squamous epithelium that lines pleural and peritoneal cavities

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12
Q

metaplasia

A

chronic irritation in epithelia is prolonged so normal epithelia replaced by stratified squamous epithelia- very resistant to stress; reversible change

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13
Q

functions of basement membrane

A
  1. separate and bind epithelium and connective tissues
  2. form a selective sieve-like barrier to regulate which molecules and cells cross interface between tissues
  3. establish polarity of epithelium
  4. guide repair
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14
Q

Lamina rara

A

clear layer that lies directly adjacent to basal surface of epithelia

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15
Q

lamina densa

A

darkly stained layer that lies immediately beneath lamina rara; together they form the basal lamina

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16
Q

lamina reticularis

A

secreted by cells in the adjacent connective tissue; third component of basement membrane

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17
Q

Alport syndrome

A

inherited disorder of Type IV collagen that affects kidney, eye, cochlea of ear; most common in males; gene mutation prevents proper production of type IV collagen network

18
Q

lateral interdigitations

A

sites where the membranes of adjacent cells do not form a straight line to from the base to the apex- fit together like puzzle pieces

19
Q

occluding junctions

A

seal cells together and form a barrier to regulate what crosses the epithelium; prevent passage of molecules via paracellular pathway

20
Q

anchoring/ adhering junctions

A

hold epithelia together by attaching cells and their cytoskeletons to each other or to the extracellular matrix; incl adhesion belts and spot desmosomes

21
Q

communicating/ gap junctions

A

allow cells to communicate with each other by chemical or electrical signals

22
Q

tight junctions

A

only in epithelia; closest to apex; form barrier between epithelium’s free surface and connective tissue ex to prevent microbes from entering bloodstream; maintain the apical and lateral cell membranes by preventing diffusion of integral membrane proteins from one surface to the other

23
Q

apical modifications

A

microvilli, sterocilia, cilia on an epithelial cell

24
Q

basal lamina

A

lamina rara+ lamina densa

25
Q

basement membrane

A

basal lamina+ lamina reticularis

26
Q

paracellular pathway

A

the space between two epithelial cells through which solutes can pass

27
Q

Steps in epithelial repair

A

a. Epithelial cells are depolarized
b. Cells become repolarized along lateral axis
c. Epithelial cells divide by mitosis
d. When cells from opposite sides of the wound meet, they make a new basement membrane, reestablish polarity, and restore the epithelium

28
Q

adhesion belts

A

just below tight junction; hold epithelial cells in a continuous sheet by forming a complete ring around the apex of the cell

29
Q

cadherins

A

transmembrane proteins in adhesion belts that connect to actin cytoskeleton; external portion of proteins have 5 domains interact in a calcium-dependent manner to bind with identidal proteins on adjacent cells cell. adhesion is disrupted if calcium concentration is low

30
Q

terminal web

A

network of cytoskeletal proteins that extends across apical cytoplasm and provides an attachment point for the basal bodies of cilia and for the actin filaments in microvilli and stereocilia

31
Q

spot desmosomes

A

type of anchoring junction; composed of dense protein plaques; keratin filaments extend away from plaques to link different spot desmosomes and to absorb and dissipate mechanical stress

32
Q

gap junctions

A

communicating junctions formed between cytoplasm of two cells by a connexon of six intermembrane protein connexins; allow small molecules to pass through; can open and close

33
Q

microvilli

A

extensions of cell membrane on apical surface; contain actin filaments

34
Q

stereocilia

A

long like cilia; contain actin filaments like microvilli; function to increase surface area

35
Q

cilia

A

extensions of apical membrane specialized for movement; contain microtubules

36
Q

hemidesmosomes

A

anchoring junctions that anchor basal surfaces of epithelial cells to basal lamina with plaque of integrin proteins

37
Q

basal infoldings

A

increase surface area on basal surface for ion transport; active transport so surrounded by many mitochondria

38
Q

merocrine

A

exocrine glands that release product by exocytosis; can be constitutive or regulated

39
Q

apocrine

A

exocrine glands that accumulate secretory products in apex then a portion of the apex pinches off and is released (ex mammary glands)

40
Q

holocrine

A

exocrine glands that secrete the entire cell along with its content (sebaceous glands only)