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ACLAM Made 2022 > Animal Models > Flashcards

Animal Models Flashcards

1
Q

Brown Norway (non agouti brn)

A

Rat

Hydronephrosis
Inducible, transplantable myeloid leukemia
Bladder carcinoma

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2
Q

ACI (agouti, wht belly and feet)

A

Rat

Congenital genitourinary anomalies
Agenisis of R kidney
High incidence of testicular tumors

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3
Q

BB/Wor (same as BB/Wistar)

A

Rat

Juvenile insulin-dependent DM

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4
Q

BUF (albino)

A

Rat

Spontaneous autoimmune thyroiditis (Hashimoto’s dz)
Other models are: BUF, BB wistar, mult mammate rat, Beagle dog, obese chicken, marmoset

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5
Q

COP (Copenhagen) brn hooded

A

Rat

prostate adenocarcinoma

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6
Q

F-344 (albino)

A

Rat

Toxicology work

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7
Q

LEW (Lewis) albino

A

Rat

Mult. sclerosis, autoimmune dz

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8
Q

LOU/C

A

Rat

Myeloma, production of IgG autoantibody

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9
Q

SHR (spontaneous Hypertensive Rat) albino

A

Rat

Hypertension, cardiovascular researsh

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10
Q

WF(wistar furth) albino

A

Rat

Mononuclear cell leukemia

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11
Q

Zucker

A

Rat

obesity

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12
Q

Brattleboro (blk hood)

A 
Rat
diabetes insipidus (auto recessive)
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13
Q

Gunn (albino)

A

Rat

jaundice, kernicterus. Remember “GUS”

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14
Q

Nude

A

Rat

T-cell deficient (auto recessive)

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15
Q

Obese SHR

A

Rat

Type 4 hyperlipoproteinemia (auto recess.)

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16
Q

Long Evans Cinnamon

A

Rat

Wilson’s dz (cu storage dz) other models are: white perch, bedlington terrier. Use Rubeanic acid stain to detect Cu.

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17
Q

Japanese spaniel

A

Dog

GM gangliosidosis

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18
Q

Carin terrier

A 
Dog
Krabbs dz (globoid cell leukodystrophy)
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19
Q

Basenji

A

Dog

Pyruvate kinase deficiency

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20
Q

Alaskan malamute

A

Dog

Human inherited hemolytic anemia factor VII and achondroplasia

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21
Q

Kerry Blue terrier

A

Dog

Spiculosis, Factor XI deficiency

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22
Q

Weimaraner

A

Dog

Syingmyelia

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23
Q

Bedlington terrier

A

Dog

Wilson’s dz(Cu storage dz) (also: LEC rats, holstein cows, white Pearch, sheep)

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24
Q

Irish setter

A

Dog

Leukocyte adhesion deficiency (also: holstein cows, Cd18- mice)

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25
Q

Gray collies

A

Dog

cyclic hematopoiesis

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26
Q

Golden retrievers

A

Dog

Duchenne muscular dystrophy

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27
Q

blue smoke persian, and beige mouse

A

Cat

Chediak-Higashi syndrome

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28
Q

Siamese

A

Cat

GM1 gangliosidosis, Wilson’s dz, Sphingomyelinosis (Neimann-Pick)

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29
Q

male tortoiseshell

A

Cat

Klinfelter’s syndrome (XXY)

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30
Q

Norwegian forest cat

A

Cat

Glycogen storage disorders

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31
Q

Mane coon cats

A

Cat

Hypertrophic cardiomyopathy

32
Q

Manx cats

A

Cat

Spina biffida

33
Q

corriedale breed (Pneumonic = CDC)

A

Ruminant

Congenital hyperbilirubinemia/hepatic organic anion excretory defect (Dubin-Johnson Sydrome) (conjugated)

34
Q

southdown breed (Pneumonic=GUS2)

A

Ruminant
congenital hyperbilirubinemia/hepatic organic anion uptake defect (Gilbert syndrome) (unconjucated) (also squirrel monkey

35
Q

dorset breed

A

Ruminant

glucose-6-phosphate dehydrogenase deficiency

36
Q

Fainting goats

A

Ruminants
inherited caprine myotonia congenita (Fainting goats)
human mytonia congenita (Thomsen’s dz)

37
Q

Holstein cows

A

Ruminant

Leukocyte adhesion deficiency

38
Q

Japanese Madaka (Oryzias latipes)

A

FIsh

carcinogenesis, toxicology

39
Q

White perch (Merone americana)

A

Fish

Wilson’s dz (Cu storage dz)

40
Q

Fathead minnow (Pimephales promelas)

A

Fish

EPA tox testing

41
Q

Bicolor Damselfish (Pomacentrus partitus)

A

Fish

Von Recklinghousen’s dz (neurofibromatosis) can also be induced in hamsters with ENU

42
Q

Rainbow trout (Oncohynchus mykiss)

A

Fish

carcinogenesis

43
Q

Carp (Cyprinus carpio)

A

Fish

Diabetes mellitus

44
Q

Platyfish (Xiphophorus spp.)

A

Fish

Malignant melanoma

45
Q

Walleye (Stizostedion vitreum)

A

Fish

Dermal sarcoma

46
Q

Spontaneous:

Heredititary hyperbilirubinemia, Crigler hajjar syndrome = kernicterus

A

Spontaneous

Gunn rat

47
Q

Spontaneous:

GUS2

A

Spontaneous

Gunn/Gilbert, Unconj/imparred Uptake, Squirrel monkey/Southdown sheep

48
Q

Spontaneous:

CDC

A

Spontaneous

Conj, Dubin johnson, Coriedale

49
Q

Spontaneous:

aganglionic megacolon

A

Spontaneous

Piebald lethal, lethal spotting mice

50
Q

Spontaneous

Type I DM

A

Spontaneous

NOD nonobese, diabetic mouse, BB wistar

51
Q

Spontaneous:

SLE, glumerulonephritis autoimmune dz

A

Spontaneous

NZB, NZW mice

52
Q 
Spontaneous
Digeroge syndrome (congenital thymic aplasia)
A

Spontaneous

Nude mice

53
Q

Spontaneous:

severe combined immunodeficiency

A

Spontaneous

SCID mice

54
Q

Spontaneous:

hypercholesterolemia

A

Spontaneous

Watanabe rabbits

55
Q

Spontaneous:

neurogenic DM

A

Spontaneous

Battleboro rats

56
Q 
Spontaneous:
Hashimotos thyroiditis (autoimmune thyroiditis)
A

Spontaneous

Obese chicken, BUF rat, BB wistar, mult mammate rat, Beagle, marmoset

57
Q

Spontaneous:

primary hypertension

A

Spontaneous

SHR rat

58
Q

Spontaneous:

Duchenne muscular dystrophy (X linked)

A

Spontaneous

golden retriver, mice, hamsters

59
Q

Spontaneous:

hemophilia A and B

A

Spontaneous

Dog

60
Q

Spontaneous:

Chediak- Higashi syndrome

A

Spontaneous

Blue persian cats, mink, Beige mouse,

61
Q

Spontaneous:

Wilson’s dz/Cu storage

A

Spontaneous

Long Evan’s Cinnamon, Bedlington terrier, Siamese cat, White perch (Merone americana)

62
Q

Spontaneous:

Leukocyte adhesion deficiency

A

Spontaneous

Holstein cows, Irish setters, CD 18, LEC rats

63
Q

Induced:

Alloxin

A

insulin dependent DM, destroy beta cells of the islets of langerhans

64
Q

Induced:

Streptozotocin

A

insulin dependent DM, destroy beta cells of the islets of langerhans

65
Q

Induced:

MPTP

A

parkinson’s dz, destroys dopamine producing cells in the brain

66
Q

Induced:

Hu-SCID mouse

A

RAG1 gene mutation prevents T and B cell antigen receptor rearrangement, SCID injected with human lymphocytes adopts the human immune system

67
Q

Nude mouse

A

Chrom 11, lacks T cell function, tumor and xenograph, Digeorges syndrome

68
Q

SCID mouse

A

Chrom 16, lacks T and B cells, gene = Prkdc

69
Q

Rag 1 and Rag 2

A

Chrom 2, lacks T and B cells,

70
Q

XID mouse

A

Chrom 14, lacks B cells, X linked

71
Q

Piebald mouse

A

Chrom 14, gene = Ednrb, aganlionic megacolon

72
Q

Mouth eaten mouse

A

Chrom 6, Lacks T and NK cells

73
Q

Beige mouse

A

Chrom 13 lacks NK cells, Chediak-Higashi syndrome

74
Q

LP mouse

A

Loop tail , audiogenic seizures, neural tube defect

75
Q

CD18 mouse

A

leukocyte adhesion, also Irish setters, holstein cattle

76
Q

RCS

A

Rat

Royal college of Surgeons, fawn hooded

ACLAM Made 2022 (3 decks)

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