Immunohematology Flashcards
Blood groups and categorized and named by
The antigen present on the RBC surface
Which type of antibodies are present in someone with group AB blood?
Neither Anti A or Anti B
Which antigen is present on the RBCs of someone with group O blood?
H
Alloantibodies refer to
Antibodies to tissue of the same species
Complete antibodies directed at A and B blood antigens are typically which class?
IgM
Select all that are true about ABO antibodies
they are thought to be formed in response to GI flora
They are used to determine blood type
They produce visible agglutination
They are formed without any prior sensitization
Why is hemolysis more successful on the presence of IgM vs IgG antibodies?
Complement (C1q) attaches more readily to IgM initiating the complement cascade
The process of “forward grouping” refers to:
Testing donor’s RBCs against known antisera (antibodies)and watching for agglutination
The inheritance pattern of ABO blood types is
Codominant
(T or F) Pre-testing blood through cross matching prevents agglutination reactions during transfusions.
True
An Rh-negative pregnant female oftentimes only mounts an immune response to a fetus’s Rh+ blood following a prior birth because:
The pregnant female’s immune system must become sensitized to the Rh antigen from a previous exposure
The Rh antibody reacts with what percentage of ABO blood?
85%
The injection given to pregnant females to prevent hemolytic disease in the fetus is called:
RhoGam
What purpose do anti-human globulins serve in blood group testing?
Highlight the presence of IgG antibodies on RBC surfaces
Select the true statements about Direct and Indirect Coombs tests.
Indirect Coombs uses in-vitro testing to determine potential for hemolysis
Direct Coombs tests for in-vivo sensitization
