Antipsychotics (Blue)

Question 1

How many symptoms are there for schizophrenia?

Answer 1

5

positive, negative, anxiety/depression, aggressive and cognitive symptoms

Question 2

What causes negative symptoms?

Answer 2

• primary deficit of the illness
• secondary to depression
• secondary to extrapyramidal symptoms (EPS)
• Secondary to environmental deprivation
• Secondary to positive smx

Question 3

What are the aetiologies of schizophrenia?

Answer 3

• genetic factors: incomplete hereditary tendency; not all schizophrenics share the same mutations of susceptibility genes
• environmental factors: possible neurodevelopmental abnormalities

Question 4

What are the few dopamine pathways of the brain?

Answer 4

1. Nigrostriatal pathway: substantia nigra to dorsal striatum; involved in voluntary movement, part of EPS, movement disorder, similar to Parkinsons
2. Mesocortical (cognition and attention)/Mesolimbic (reward and emotion) pathways: dopamine inc in acute schizophrenia
3. tuberoinfundibular: pathway from the hypothalamus to anterior pituitary regulates prolactin secretion into the blood circulation

Question 5

What are the pprty of antipsychotic atypical?

Answer 5

• greater affinity at 5-HT2 receptors
• greater affinity at D4 receptors
• mixed antagonism at a-adrenoceptors, H1 histamine receptors, muscarinic acetylcholine receptors, and 5-HT2 receptors

but these pprty dont define atypicality

Question 6

Amisulpiride increases ______ release

Answer 6

Prolactin

tuberoinfundibular: pathway from the hypothalamus to anterior pituitary regulates prolactin secretion into the blood circulation