Mid Module Questions Practice

Question 1

What is a partition coefficient?

Answer 1

Ability of drug to distribute into immiscible systems.

Question 2

What are the challenges of drug absorption?

Answer 2

Drug needs to dissolved in aqueous media.

Drug needs to cross phospholipid bilayer and pass through non aqueous layer of PB- hence needs to be hydrophilic and to an extent hydrophobic.

Question 3

How many solvents are used in partition coefficient studies???

Answer 3

Octanol
Propylene glycol-PGDP
Chloroform
Cyclohexane

Question 4

What are the mechanisms of granulation?

Answer 4

Adhesion and cohesion forces in immobile films.

Interfacial forces in mobile liquid films.

Solid bridges.

Attractive forces between solid particles.

NTB (Nucleation, Transition, Ball Growth).

Question 5

What’s Adsoption?

Answer 5

A surface effect.

Electrostatic interactions between compound and surface of the stationary phase.

Question 6

What is Partition?

Answer 6

Applies to bonded phases.

Where the stationary phase is liquid coated onto a solid.

Question 7

What is ion exchange?

Answer 7

Solute ions in the mobile phase can exchange with similarly charged ions bound to the stationary phase.