1.1 - What is Cardiovascular Disease? Flashcards

1
Q

What is diffusion?

A

The movement of molecules or ions from a region of their high concentration to a region of their lower concentration by relatively slow and random movement of molecules.

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2
Q

In what type of organism is passive diffusion enough to meet their needs?

A

Unicellular organisms

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3
Q

Larger multi cellular organisms are too large to rely on passive diffusion. What do they use instead?

A

Mass transport systems to move substances efficiently over longer distances by mass flow (circulatory system). This often comes on the form of a heart and blood in animals.

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4
Q

Where is an open circulatory system found and what is it?

A

In insects and other small animals, open circulatory systems circulate blood in large open spaces or cavities surrounding the organs.

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5
Q

How does diffusion occur in open circulatory systems?

A

Substances diffuse between the blood and cells of tissues.

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6
Q

How does the open circulatory system work?

A

When the heart muscle relaxes, blood is drawn from the cavities back into the heart through small, valved openings

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7
Q

What is a closed circulatory system and where is it found?

A

Found in many animals including all vertebrates. Blood is enclosed within tubes (blood vessels).

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8
Q

How does the closed circulatory system work?

A

Higher blood pressure as blood is forced along narrow channels instead of larger cavities. The blood travels faster and is more efficient at delivering substances.

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9
Q

How does diffusion take place in an open circulatory system?

A

Large numbers of capillaries come into close contact with the cells in the body where substances are exchanged between the blood and cells across a thin wall.

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10
Q

What is a single circulatory system and where is it found?

A

Animals with closed circulation systems either have single or double circulatory systems. Fish have a single circulatory system.

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11
Q

How does a single circulatory system work?

A

The heart pumps deoxygenated blood to the gills. Gaseous exchange takes place to oxygenate the blood. The blood leaves the gills and flows round the rest of the body before returning to the heart. (The blood passes through the heart once for each circulation).

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12
Q

What kinds of animals have a double circulatory system?

A

Birds and mammals

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13
Q

How does a double circulatory system work?

A

The right ventricle pumps deoxygenated blood to the lungs where gaseous exchange takes place. The blood returns to the heart and is pumped a second time by the left ventricle to the rest of the body.

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14
Q

What is the benefit of a double circulatory system?

A

The blood is given an additional “boost”, reducing the time it takes to circulate around the body. This gives birds and mammals a high metabolic rate as oxygen and other substances are delivered more rapidly to meet demands

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15
Q

What is the main fluid in blood?

A

Plasma - mainly water and contains dissolved substances such as glucose, oxygen and CO2.

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16
Q

Name 5 substances transported in the plasma.

A
  • Proteins
  • Amino acids
  • Salts
  • Enzymes
  • Hormones
  • Antibodies
  • Glucose
  • Oxygen
  • CO2
  • Urea
17
Q

What is urea?

A

The toxic waste product from the breakdown of proteins.

18
Q

What are three cells transported in the blood.

A
  • Red blood cells
  • White blood cells
  • Platelets
19
Q

What is another role of blood besides transport?

A

Temperature regulation

20
Q

What is atherosclerosis?

A

Disease process leading to CHD and strokes. Either block an artery or increase the chance of a blood clot to block artery.

21
Q

What can atherosclerosis cause?

A
  • Increased blood pressure
  • Stroke
  • Heart attacks
  • Gangrene and dead cells
22
Q

Outline the process of atherosclerosis?

A
  • High blood pressure causes damage to endothelium
  • Inflammatory response
  • White blood cells move into the artery wall and cause buildup of cholesterol
  • Fatty deposit builds up called atheroma
  • Calcium salts and fibrous tissue form a plaque
  • Rising blood pressure, positive feedback builds up.
23
Q

Why is the clotting cascade triggered in damaged vessels?

A

Direct contact of platelets with vessels triggers a cascade

24
Q

How do platelets adapt?

A

Platelets change from flattened discs to spheres with projections.

25
Q

Outline the blood clotting cascade

A
  • Damaged tissue and platelets release thromboplastin
  • Thromboplastin catalyses conversion of prothrombin into thrombin
  • Calcium and Vitamin K help this process
  • Thrombin catalyses soluble fibrinogen into insoluble fibrin
  • A mesh of fibrin traps platelets and red blood cells to form clot