U3-4 - Pharmaceutical Chemistry Flashcards
Drug
A substance that alters the biochemical processes in the body.
Besides the active drug(s), what else can medicines contain?
Fillers to add bulk or sweeteners to improve the taste
Agonists and antagonists both act on _____.
receptors
An agonist __________ the ______________ and binds to the receptor molecules to produce a response similar to the natural active compound.
An agonist mimics the natural compound and binds to the receptor molecules to produce a response similar to the natural active compound.
An agonist mimics the natural compound and ________ to the ________ molecules to produce a response similar to the natural active compound.
An agonist mimics the natural compound and binds to the receptor molecules to produce a response similar to the natural active compound.
An agonist mimics the natural compound and binds to the receptor molecules to produce a response _________ to the natural active compound.
An agonist mimics the natural compound and binds to the receptor molecules to produce a response similar to the natural active compound.
An antagonist _______ the __________ from binding to the receptor, and so blocks the natural response from occurring.
An antagonist prevents the natural compound from binding to the receptor, and so blocks the natural response from occurring.
An antagonist prevents the natural compound from _______to the ______, and so blocks the natural response from occurring.
An antagonist prevents the natural compound from binding to the receptor, and so blocks the natural response from occurring.
An antagonist prevents the natural compound from binding to the receptor, and so _________________ from occurring.
An antagonist prevents the natural compound from binding to the receptor, and so blocks the natural response from occurring.
Drugs that that act on enzymes are ________.
(enzyme) inhibitors
(Enzyme) inhibitors
Substances which act by binding to the active site of the enzyme and blocking the reaction normally catalysed there.
The shape of the drug molecule must complement _______.
the shape of the receptor/active site
How does a drug molecule bind to the receptor/active site?
Intermolecular forces (e.g. H-bonds) or ionic bonds.
Pharmacophore
Structural fragment which confers pharmacological acitivity.
(E.g. has a certain shape/size/functional groups)
Both drugs shown have a similar effect.
How do you determine which part is the pharmacophore?
Find the fragment which appears in both compounds.
