Heart failure Flashcards
What is heart failure?
This is a syndrome where pts experience typical symptoms such as sob, ankle swelling and fatigue as well as signs such as elevated jugular pressure, pulmonary crackles and displaced apex beat which results from an abnormality in the cardiac structure or function
What are the major criteria when diagnosing HF?
Paroxyzmal noctural dyspnoea Neck-vein distension Rales Cardiomegaly Acute pulmonary oedema S3 gallop Increased venous pressure Hepatojugular reflex Loss of weight more than 4.5kg during 5 days
What are the minor criteria when diagnosing HF?
Ankle oedema Night cough Dyspnoea on exertion Hepatomegaly Pleural effusion Tachycardia (more than 120b/min)
How is HF diagnosed?
Either 2 major criteria
OR 1 major criteria with 2 minor criteria
What are the typical symptoms of HF?`
SOB Orthopnoea Paroxysmal nocturnal dyspnoea Reduced exercise tolerance Fatigue, tiredness, increased time to recover after exercise Peripheral oedema
What are the NYHA classifications for HF?
Class 1: no limitation of physical activity.
Class 2: slight limitation of physical activity - SOB, fatigue or palpitations
Class 3: comfortable at rest but ordinary physical activity is limited as it results in SOB, fatigue or palpitations
Class 4: symptoms at rest and during exercise are present
What are the causes of HF?
CAD/ACS -
Idiopathic dilated cardiomyopathy -
Infection, hypoxia and alcohol abuse - all these reduce contractility
valve disease - as this affects the volume/pressure overload
hypovolemia and constrictive pericarditis - causes insufficient volume
drugs - chemotherapy
electrical disorders - vtach which can cause HF
What is the preload?
Volume coming into the ventricles at the end diastolic pressure
When is the preload increased?
Hypervolemia
Regurgitation of cardiac values
What is the afterload?
the resistance the left ventricle must overcome to circulate blood.
this is increased to minimize the symptoms of HF
When is the afterload increased?
hypertension
vasoconstriction
these lead to an increase in the cardiac workload and in the afterload
What are the compensatory mechanisms in HF?
Sympathetic NS
RAAS
What are the counter-regulatory mechanisms?
the chambers of the heart try to release hormones which try to compensate the negative effects of the other hormonal mechanisms.
Natriuretic peptides (ANP and BNP) promote diuresis (increase urine output) and vasodilation.
these have a negative impact long term
What is systolic failure?
the inability of the ventricle to contract normally which leads to a decrease in CO. EF <40%
What is diastolic failure?
inability of the ventricle to relax and fill normally causing increasing filling pressure. EF is >50%