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Advanced Pharm Exam 2 > Psych > Flashcards

Psych Flashcards

1
Q

positive symptoms of schizophrenia

A

suspiciousness, delusions, hallucinations, conceptual disorganization

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2
Q

negative symptoms of schizophrenia

A

flat affect, alogia, anhedonia, avolition

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3
Q

cognitive symptoms of schizophrenia

A

impaired attention, impaired working memory, impaired executive function

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4
Q

monitoring for atypical antipsychotics

A 
BG/hgbA1c
LFTs
neurologic function
serum cholesterol
weight
QTC
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5
Q

teaching for atypical antipsychotics

A

may take several weeks before full effects
may need to taper off
avoid alcohol

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6
Q

atypical antipsychotics examples

A 
aripiprazole (Abilify)
lurasidone (Latuda)
olanzapine (Zyprexa)
Quetapine (Seroquel)
Risperidone (Risperdal); Paliperidone (Invega)
Ziprasiidone (Geodon)
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7
Q

atypical antipsychotics least likely to cause weight gain

A

abilify (aripiprazole)
lurasidone (latuda)
zipradisone (geodon)

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8
Q

atypical antipsychotics oral disintegrating tab vs no disintegrating formulations

A

peak serum concentration occurs slower in oral disintegrating tabs

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9
Q

atypical antipsychotics that need to be taken with food

A

lurasidone (latuda)

ziprasidone (geodon)

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10
Q

paliperidone is a metabolite of which atypical antipsychotic?

A

respiridone

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11
Q

common AEs of atypical antipsychotics

A

sedation, weight gain, extrapyramidal effects, dizziness, poor thermoregulation, glucose dysregulation, black box warning for increased risk w dementia, QT prolongation

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12
Q

akathisia

A

restlessness

can increase risk for suicide

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13
Q

patho of depression

A

changes in monoamine neurotransmitters including NE, 5-HT, and DA

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14
Q

symptoms of serotonin syndrome

A

euphoria, DROWSINESS, HYPERACTIVE REFLEXES, rapid muscle contractions, dizziness, SWEATING, hyperthermia, shivering,, hyperactive bowel sounds, death

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15
Q

AEs of SSRIs

A

serotonin syndrome, nausea, drowsiness/dizzines, HA/tremor, black box warning

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16
Q

SSRI interactions

A

other drugs containing serotonin

alcohol

CYP2D6

17
Q

optimal dosing of escitalopram (Lexapro)

A

20 mg daily

> 20mg does not have effect

18
Q

which SSRI has significant GI side effects?

A

paroxetine

19
Q

SSRIs to avoid d/t CYP2D6 pathway

A

paroxetine (paxil)
fluoxetine (prozac)

citalopram or sertraline least likely to have interactions

20
Q

SSRI with longest half life

A

fluoxetine

good for pts who are poorly adherent or have had trouble w discontinuation previously

21
Q

SSRI least likely to cause weight gain

A

paroxetine

22
Q

SNRI examples

A

duloxetine (cymbalta)
venlafaxine (effexor XR)
desvenlafaxine (prestiq)

23
Q

AEs of TCAs

A

dr mouth, dry eyes, blurred vision, sun sensitivity, sedation, glucose dysregulation

24
Q

TCA examples

A

amitriptyline
nortriptyline
doxepin (sinequan)
mirtazapine (remeron)

25
Q

trazodone moa

A

increases serotonin and norepinephrine to cause antidepressive effects

used off label for sleep

26
Q

trazodone AEs

A

sedation, orthostasis, dry mouth, nausea

less likely to cause sexual dysfunction, agitation, and weight changes than other antidepressants

27
Q

vilazodone (viibryd) MOA

A

SSRI and 5HT-1A partial agonist

28
Q

lithium AEs

A

sodium dysregulation, dizziness/drowsiness, nausea

29
Q

benzodiazepines MOA

A

produce CNS depression by enhancing GABA-benzidiazepine receptor compless

act at the level of the limbic, thalamic, hypothalamic regions of CNS

30
Q

what pregnancy category are benzos?

A

D - may cause congenital malformations in first trimester

31
Q

benefits of buspirone (buspar) for anxiety

A

no impaired psychomotor, sedation, dependence, or decreased concentration

32
Q

MOA of eszopiclone (lunesta) & zolpidem (ambien)

A

non-benzodiazepine hypnotics

selectively bind to GABA receptors to induce sleepiness

33
Q

tamazepam (restoril) use

A

benzodiazepine indicated for sleep

34
Q

AEs of stimulants

A

upset stomach, insomnia, HA, rebound symptoms, stimulant-induced sleep disturbances

35
Q

atomexetine (strattera) MOA & use

A

SNRI approved for ADHD maintenance

Advanced Pharm Exam 2 (3 decks)

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