Tequila

Question 2

Why do women have higher peak blood levels of EtOH with the same dose as men?

Answer 2

Gastric ADH enzymes are either less active or non-existent in women. Some of the alcohol is metabolized in the stomach in men.

Question 3

Drug that inhibits acetaldehyde dehydrogenase and is used to treat alcoholism.

Answer 3

Disulfiram-makes hangovers really bad

Question 4

Two receptors in the CNS that ethanol influences.

Answer 4

GABA-a receptors: increases sensitivity for easier chloride channel openingNMDA: inhibits excitatory NMDA activation

Question 5

How is alcohol withdrawal treated?

Answer 5

Long-acting benzodiazepines to avoid: delirium, seizures, and arrhythmiaShort-acting benzos like lorazepam oxazepam if there are liver problems

Question 6

Which NMDA receptor antagonist will treat withdrawal?

Answer 6

Acomprosate

Question 7

Which opioid antagonist drug can treat the alcohol cravings?

Answer 7

Naltrexone

Question 8

Treatment for methanol poisoning.

Answer 8

Hemodialysis w/ ethanol-EtOH competes with methanol for the ADH enzyme and less formaldehyde is produced allowing the dialysis to clear the methanol

Question 9

Drug combination approved to treat both methanol and ethylene glycol poisoning.

Answer 9

Fomepizole + Folic Acid(fomepizole not used often b/c it’s expensive)