Pentose Phosphate Pathway

Question 0

Pentode phosphate pathway

Answer 0

Shunt off glycolysis
Stats with glucose-6-P
Makes ribose, a pentose: DNA, RNA 
Makes NADPH: fatty acid synthesis, cholesterol synthesis, glutathione 
End products feed back into glycolysis
Substrate driven, how much G6P is around

Question 1

Important concepts of PPP

Answer 1

Provides penthouses for nucleotides and nucleic acids
Provides NADPH for biosynthesis and detoxification reactions
Driven by mass action

Question 2

Oxidative part of PPP

Answer 2

Provides NADPH for reductive biosynthesis, irreversible

Can provide ribose-5-P for DNA and RNA

Question 3

Non oxidative part of PPP

Answer 3

If ribose not needed, get rid of it by carbon shuffling
Shuffle carbons until they have formed intermediates of glycolysis
Cells need to feed a 5C ribulose p into glycolysis
Only 3 and 6C molecules allowed
Shuffle and get out 2 6C and 1 3C sugars