Pharma

Question 1

Anticlotting drugs are used in

Answer 1

tx and prevention of MI, other acute coronary syndromes, ischemic stroke, AF, DVT

Question 2

Anticoagulant & throbolytic drugs are effective in ….

Antiplatelet drugs are useful only for…

Answer 2

both venous & arterial thrombosis

of arterial disease

Question 3

Parenteral anticlotting drugs are never used I.M. Because of

Answer 3

hematoma risk)

Question 4

Action of heparin (UFH) is monitored with

Answer 4

aPTT

Question 5

…reverses the effects of UFH (hebarin)

Answer 5

Protamine

Question 6

Protamine reverses

Answer 6

partially reverses

LMW heparins, but not fondaparinux

Question 7

Warfarin inhibits … and used …

Answer 7

vit K epoxide reductase

orally

Question 8

Vit K dependent factors are

Answer 8

II, VII, IX and X

Question 9

Clotting factors have half lives 0f ….. h in plasma so onset of anticoagulant action is relatively …

Answer 9

8-60

slow

Question 10

What inhibits vit k

Answer 10

Warfarin

Question 11

Slow reversal with vit K (…. h)

Answer 11

6-24

Question 12

Effect of warfarin is monitered with

Answer 12

PT

INR

Question 13

Warefarin is Contraindicated in pregnant woman because

Answer 13

cause bone defects

and bleeding in fetus

Question 14

In warfarin There is a period of hypercoaglability due to

Answer 14

deficiency of protein C early in the therapy

Question 15

Direct oral anticoagulants (dabigatran, rivaroxaban) bleeding rate compared to warfarin

Answer 15

Lower (doesnt need monitering)

Question 16

Only … is used for antiaggregation,

Answer 16

aspirin

Question 17

When using thrombolytic agents in stroke, …must be ruled out

Answer 17

cerebral hemorrhage

Question 18

Plasminogen to plasmin

Answer 18

Reteplase

Question 19

Man has acute infarction, fibrigen drug is used

Answer 19

Hhemorrhagic stroke

Question 20

Mechanism of action of clopidogrel

Answer 20

Active metabolite of clopidogrel inhibits Adp

Question 21

Graph

Answer 21

Drug b stimulates

Question 22

Anticoagulant inhibits thrombin

Answer 22

Dabigatran

Question 23

Sudden stoping of medication leads to

Answer 23

Stroke

Question 24

Test provide info about coagulation status of oatient taking apixaban

Answer 24

Factor X test

Question 25

Enoxapfin and unfractionated hebarin can be used without

Answer 25

Monitering

Question 26

7 inr

Answer 26

Vit k

Question 27

Severe thrombocytopenia in response to unfractioned heparin

Answer 27

Bivalirudin