Drugs For Psychosis

Question 1

Psychosis

Answer 1

Loss of contact with reality

Consists of delusions, hallucinations,disorganized behavior, difficulty relating to others, and paranoia

Question 2

Schizophrenia

Answer 2

Overactive dopaminergic system

Caused by D2 receptor issue in basal nuclei

Positive symptoms- hallucinations/delusions, disorganized thought

Negative- amotivation amd apathy etc

Question 3

Comventional antipsychotics (schizo) drugs

Answer 3

Prochlorperazine (compazine)

Haloperidol (haldol)

Question 4

Prochlorperazine (compazine) moa

Answer 4

D2 receptor antagonism/phenothiazine class

Most effective tx of positive symptoms

Extrapyramidal symptoms

Question 5

Haloperidol (haldol) moa

Answer 5

D2 receptor antagonism/non-phenothiazine class

Less sedation/hypotension but higher EPS

Question 6

Adverse Effects of Phenothiazine Drugs

Answer 6

Parkinsons like symptoms or abnormal movements/behaviors

Question 7

Atypical Antipsychotics (Schizo) Drugs/Moa

Answer 7

(-) D2 (-) 5HT (-) alpha 1
Has fewer EPS bc of low affinity for D2

Risperdone(risperdal)
Clozapine(clozaril)
Aripiprazole(abilify)

Question 8

Risperdone(risperdal) moa

Answer 8

(-) D2 (-) 5HT2a (-) alpah 1

Question 9

Clozapine(clozaril) moa

Answer 9

(-) D2 and (-) 5HT2a

Question 10

Aripiprazole(abilify) moa

Answer 10

D2 (-), varied 5HT receptor profile