PPS COMPILED SAMPLEX [PART 2 OF 5] - 652 items total with Rationale Flashcards

1
Q
"Treatment of retentive encopresis
A. Laxative
B. Contrast enema
C. Clearance of impacted fecal material followed by the short-term use of mineral oil or laxatives
D. None of the above"
A

C

“Nelson 21st p1961
If an impaction is present on the initial physical examination, an enema is usually required to clear the impaction while stool softeners are started as maintenance medications. Typical regimens include the use of polyethylene glycol preparations, lactulose, or mineral oil. Prolonged use of stimulants such as senna or bisacodyl should be avoided. “

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2
Q

“Patient with diarrhea. Does not stop with fasting. What is the mechanism?

a. Decreased absorption, increased secretion, electrolyte transport
b. Defect in neuromuscular unit/stasis
c. Decreased functional capacity
d. Maldigestion, transport defects, ingestion of unabsorbable substances”

A

A

“Nelson 21st p1907. Table 332.10 Mechanisms of Diarrhea
Secretory
- decreased absorption, increased secretion, electrolyte transport
- watery stool, normal osmolality with ion gap <100mOsm/kg
- e.g. Cholera, ETEC, C. difficile
- Persists during fasting, bile salt malabsorption can also increase intestinal water secretion, no stool leukocytes

Osmotic

  • maldigestion, transport defects, ingestion of unabsorbable substances
  • watry stool, acidic with reducing substances, increased osmolality with ion gap >100 mOsm/kg
  • e.g. Lactase deficiency, galactose malabsorption
  • Stops with fasting, increased breath hydrogen with carbohydrate malabsorption, no stool leukocytes

Increased motility

  • decreased transit time
  • loose to normal appearing stool, stimulated by gastrocolic reflex
  • e.g. irritable bowel syndrome, thyrotoxicosis
  • Infection can also contribute to increased motility

Decreased motility

  • defect in neuromuscular units/stasis
  • loose to normal appearing stool
  • e.g. pseudo-obstruction, blind loop
  • Possible bacterial overgrowth due to stasis

Decreased surface area (osmotic/motility)

  • decreased functional capacity
  • watery stool
  • e.g. short bowel syndrome, rotavirus, celiac disease
  • Might require parenteral alimentation

Mucosal invasion

  • inflammation, decreased colonic reabsorption, increased motility
  • blood and increased WBC in stool
  • e.g. Salmonella, shigella, amebiasis, Campylobacter”
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3
Q
"A child with repeated bouts of vomiting suddenly developed hematemesis. What mechanism will explain this?
A. Blunt trauma
B. Tear on esophageal mucosa
C. Rupture of esophageal varices
D. Upper GI bleeding"
A

B

“Nelson 21st p1941
The majority of esophageal perforations in children are from blunt trauma (automobile injury, gunshot wounds, child abuse) or are iatrogenic (cardiac massage, NGT placement, traumatic intubation). Esophageal rupture has followed forceful vomiting and patients with anorexia and has followed esophageal injury due to caustic ingestion and foreign body ingestion.

Spontaneous esophageal rupture (Boerhaave syndrome) is less common and is associated with sudden increases in intraesophageal pressure wrought by situations such as vomiting, coughing or straining in stool.

Symptoms of esophageal perforation include pain, neck tenderness, dysphagia, subcutaneous crepitus, fever, tachycardia, bleeding, and cold water polydipsia.

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4
Q
"Diarrhea with gaseous abdominal distention stool with >2+ reducing substance, predominant nutrient malabsorbed
A. Carbohydrates 
B. Fat
C. Protein
D. Amino acid"
A

A

Nelson 21st 1989 - The measurement of carbohydrate in the stool for pH and the amount of
reducing substances is a simple screening test when available. An acidic
stool with >2+ reducing substance suggests carbohydrate malabsorption.
Sucrose or starch in the stool is not recognized as a reducing sugar
until after hydrolysis with hydrochloric acid, which converts them to
reducing sugars.

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5
Q
"A patient has abdominal pain accompanied by straining efforts with legs and knees flexed. Presented at ER in a shock- like state. Has sausage-shaped mass on abdominal PE. Diagnostic test with high specificity
A. CT scan
B. Contrast Enema
C. Abdominal UTZ
D. Plain Xray"
A

C

“Nelsons 21st p1966 Intussussception
The classic triad of pain, a palpable sausage-shaped abdominal mass, and bloody or currant-jelly stool is seen in <30% of patients with intussussception. The combination of paroxysmal pain, vomiting, and a palpable abdominal mass has a positive predictive value of >90%; the presence of rectal bleeding increases this to approximately 100%

Palpation of the abdomen usually reveals a slightly tender sausage-shaped mass, slightly ill-defined, which might increase in size and firmness during a paroxysm of pain and is most often in the right upper abbdomen, with its long axis cephalocaudal. If it is felt in the epigastrisum, the long axis is transverse. Approximately 30% of patients do not have a palpable mass.

Ultrasound has a sensitivity of approximately 98-100% and a specificity of approximately 98% in diagnosing intussussception. The diagnostic findings of intusussception on ultrasound include a tubular mass in longitudinal views and a doughnut or target appearance in transverse images. “

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6
Q
"Patient 3 months after liver transplant came in for Hep A vaccination prior to travel in 2 months time.
A. Hepatitis A vaccine
B. Hepatitis A lg
C. Hepatitis A vaccine and IG
D. None"
A

C

“Nelsons 21st p2109
Hepatitis A Ig is recommended for preexposure prophylaxis for susceptible travelers to countries where HAV is endemic, and it provides effective protection for up to 2 mo. HAV vaccine given anytime before travel is preferred for preexposure prophylaxis in healthy persons, but Ig ensures an appropriate prophylaxis in children younger than 12 mo, patients allergic to a vaccine component, or those who elect not to recieve the vaccine. If travel is planned in <2wk, older patients, immunocompromised hosts, and those with chronic liver disease or other medical conditions should recieve both Ig AND HAV vaccine “

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7
Q
"Patient presented at ER with RUQ pain, lying on his side with hips and knees flexed. On PE, patient is uncomfortable and the abdomen is distended and tender. Which diagnostic test is highly specific and should be done immediately?
A. Serum lipase
B. Abdominal UTZ
C. Abdominal CT
D. Serum amylase"
A

A

“Nelsons 21st p2076

  1. Mild acute pancreatitis - AP that is not associated with organ failure, local or systemic complications, and usually resolved within the 1st wk after presentation. This is the most common form of AP
  2. Moderately severe acute pancreatitis - AP with either transient organ failure/dysfunction (lasting <48hr) or development of local or systemic complications, such as exacerbation of previously diagnosed comorbid disease
  3. Severe acute pancreatitis - AP with development of organ dysfunction that persists longer than 48hr. Persistent organ failure may be single or multiple. Severe AP is uncommon in children

The patient with AP has moderate to severe abdominal pain, persistent vomiting, and possibly fever. The pain is epigsatric or in either upper quadrant, stead, often resulting in the child’s assuming an antalgic position with hips and knees flexed, sitting upright, or luying to the side. The child is uncomfortable, irritable, and appears acutely ill. The abdomen may be distended and tender and a mass may be palpable.

AP is usually diagnosed by measurement of serum lipase and amylase activities. Serum lipase is considered the test of choice for AP, as it is more specific than amylase for acute inflammatory pancreatic disease and should be determined when pancreatitis is suspected. “

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8
Q

An infant has history of vomiting and regurgitation 3-4x after feeding. What will you do

A

NORMALIZATION OF ABNORMAL FEEDING TECHNIQUES

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9
Q

“A patient with characteristics of marasmus. What deficiency?

a. Carbohydrates
b. Fats
c. Protein
d. Micronutrients”

A

C

”"”Nelson 21st p336
Severe acute malnutrition is defined as severe wasting and/or bilateral edema. Other terms are marasmus (severe wasting), kwashiorkor (characterized by edema), and marasmic-kwashiorkor (severe wasting and edema).

Severe wasting is most visible on the thighs, buttocks, and upper arms, as well as over the ribs and scapulae, where loss of fat and skeletal muscle is greatest. Wasting is preceded by failure to gain weight and then by weight loss. The skin loses turgor and becomes loose as subcutaneous tissues are broken down to provide energy. The face may retain a relatively normal appearance, but eventually becomes wasted and wizened. The eyes may be sunken from loss of retroorbital fat, and lacrimal and salivary glands may atrophy, leading to lack of tears and a dry mouth. Weakened abdominal muscles and gas from bacterial overgrowth of the upper gut may lead to a distended abdomen. Severely wasted children are often fretful and irritable.”””

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10
Q

“Preventive measures for GERD

a. Elevate head of bed 3inches
b. No food or drinks 1 hr before bedtime
c. Avoid caffeinated drinks
d. All of the above”

A

D

“Nelson 21st p1937
Dietary measures for infants include normalization of any abnormal feeding techniques, volumes, and frequencies. Thickening of feeds or use ot commercially prethickened formulas increases the percentage of infants with nor regurgitation, decreases the frequency of daily regurgitation and emesis, and increases the infant’s weight gain.

Older children should be counseled to avoid acidic or reflux-inducing foods (tomatoes, chocolate, mint) and beverages (juices, carbonated and caffeinated drinks, alcohol). Weight reduction for obese patients and elimination of smoke exposure are crucial measures for all ages.

Positioning measures are particularly important for infants, who cannot control their positions independently. Seated position worsens infant reflux and should be avoided in infants with GERD. When the infant is awake and observed, prone position and upright carried position can be used to minimize reflux. Lying in the flat supine position and semi-seated positions (e.g. car seats, infant carriers) in the postprandial period are considered provocative positions for GER and therefore should be avoided.

The efficacy of positioning for older children is unclear, but some evidence suggests a benefit to left side position and elevation during sleep. The head should be elevated by elevating the head of the bed, rather than using excess pillows, to avoid abdominal flexion and compression that might worsen reflux. “

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11
Q
"A 3-week old male had intermittent vomiting. On examination, a firm, movable, olive-shaped hard mass was palpable in the mid-epigastric region. What imaging study can best help confirm the diagnosis?
A. Scout film of the abdomen
B. Abdominal ultrasound
C. Manometry
D. Abdominal CT scan"
A

B

“Nelsons 21st p1947 Pyloric stenosis
The diagnosis has traditionally been established by palpating the pyloric mass. The mass is firm, movable, approximately 2cm in length, olive-shaped, hard, best palpated from the left side, and located above and to the right of the umbilicus in the mid-epigastrium beneath the liver edge.

Two imaging studies are commonly used to establish the diagnosis. Ultrasound examination confirms the diagnosis in the majority of cases. Criteria for diagnosis include pyloric thickness 3-4mm, an overall pyloric length 15-19mm, and a pyloric diameter of 10-14mm. Ultrasonography has a sensitivity of approximately 95%. When contrast studies are performed, they demonstrate an elongated pyloric channel (string sign), a bulge of pyloric muscle into the antrum (shoulder sign) and parallel streaks of barium seen in the narrowed channel, producing a double tract sign. “

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12
Q
"Which of the following features best distinguishes Hirschsprung's disease from functional constipation?
A. Failure to thrive
B. Encopresis
C. Enterocolitis
D. Onset after 2 years of age"
A

C

“Nelson 21st p1962 Table 358.9 Distinguishing features of Hirschsprung disease and functional constipation

FUNCTIONAL CONSTIPATION

Onset after 2 yrs 
Encopresis common
Failure to thrive uncommmon
Enterocolitis none 
Forced bowel traning usual
Abdominal distension uncommon 
Poor weight gain rare
Rectum filled with stool
Rectal examination: stool in rectum
No malnutrition

Anorectal manometry reveals relaxation of internal anal sphincter
Rectal biopsy is normal
Barium enema shows massive amounts of stool with no transition zone

HIRSCHSPRUNG DISEASE

Onset at birth 
Encopresis very rare
Failure to thrive possible
Enterocolitis possible
Forced bowel training: none
Abdominal distension common
Poor weight gain common
Rectum empty 
Rectal examination: explosive passage of stool
Malnutrition: possible 

Anorectal manometry reveals failure of internal anal sphincter relaxation
Rectal biopsy shows no ganglion cells
Barium enema shows transition zone with delayed evacuation of barium”

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13
Q

“3 year old takes 8 months old sister’s rattle

a. Slap
b. Scold
c. Time out
d. Take away toys”

A

C

“Nelson 21st p146
Although some cultures condone the use of corporal punshment for discliplining of young children, it is not a consistently effective means of behavioral control. As children habituate to repeated spanking, parents have to spank ever harder to achieve the desired response, increasing the risk of serious injury.

Sufficiently harsh punishment may inhibit undesired behaviors, but at great psychologic cost. Children mimic the corporal punishment that they recieve; children who are spanked will have more aggressive behaviors later.

Whereas spanking is the use of force, externally applied, to produce behavioral change, discipline is the process that allows the child to internalize controls on behavior. Alternative discipline strategies should be offered, such as the ““countdown”” for transitions along with consistent limit setting, ““time outs”” or ““time ins”” (breaks from play with caregiver present and interacting), clear communication of rules, and frequent approcal with positive reinforcement of productive play and behavior. Punishment should be immediate, specific to the behavior, and time-limited. Time-out for approximately 1min/yr of age is very effective. “

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14
Q

“A child raised in an environment of violence is linked to:

a. Violence
b. Stealing
c. Runaway
d. Depression/ anxiety”

A

D

“Nelson 21st p86
All types of violence have a profound impact on health and development both psychologically and behaviorally. Children can come to see the world as a dangerous and unpredictable place. This fear may thrwart their exploration of the environment, which is essential to learning in childhood. Children may experience overwhelming terror, helplessness, and fear, even if they are not immediately in danger.

High exposure to violence in older children correlates with poor performance in school, symptoms of anxiety and depression, and lower self esteem. Violence, particularly intimate partner violence, can also teach children especially powerful early lessons about the role of violence in relationships. Violence can change the way that children view their future; they may believe that they could die at an early age and thus take more risks.

Some children exposed to severe and/or chronic violence may suffer from PTSD, exhibiting constricted emotions, difficulty in concentrating, autonomic disturbances, and reenactment of the trauma through play or action. “

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15
Q
"Which is not part of the HEEADSSS?
a. Home
b. Education
C. Abuse
d. Spirituality"
A

C

“Prev Ped 2018 p16
Complete history-taking to screen for risks and protective factor using the tool HEEADSSS which means Home, Education/Employment, Eating, Drugs, Sexuality, Suicidality/depression, Safety, Strength/spirituality “

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16
Q

“Modifiable factor, associated with timing for adolescent growth?

a. Genetic
b. Environmental
c. Hormonal”

A

B

Environmental facotrs are the only modifiable factor among the choices

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17
Q

“True of gender dysphoria in children EXCEPT
a. Strong desire of gender of the opposite sex
b. A strong desire to be rid of one’s primary and/or secondary
sex characteristics
c. Prefers playmates of opposite sex
d. Dislike of one’s sexual anatomy”

A

B

“Nelsons 21st p1023 Table 133.2 Summary of DSM-5 diagnostic criteria for gender dysphoria

Gender dysphoria in children
A. A marked incongruence between one’s experienced/expressed gender and assigned gender, of at least 6mo duration, as manifested by at least 6 of the following (1 of which must be criteria A1)

  1. A strong desire to be of the other gender or an insistence that one is the other gender (or some aternative gender different from one’s associated gender)
  2. In boys (assigned gender), a strong preference for dressing or simulating female attire; or in girls (assigned gender), a strong preference for wearing only typical masculine clothing and a strong resistance to the wearing of typical feminine clothing
  3. A strong preference for cross-gender roles in make-believe play or fantasy play
  4. A strong preference for the toys, games, or activities stereotypically used or engaged in by the other gender
  5. A strong preference for playmates of the other gender
  6. In boys (assigned gender), a strong rejection of typically masculine toys, games, and activities, and a strong avoidance of rough-and-tumble play; or in girls (assigned gender), a strong rejection of typically female toys, games, and activities
  7. A strong dislike of one’s sexual anatomy
  8. A strong desire for the primary and/or secondary sex characteristics that match one’s experience gender

B. The condition is associated with clinically significant distress or impairment in social, school, or other important areas of functioning”

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18
Q

“True of Asperger syndrome EXCEPT

a. Persistent deficits in social communication and social interaction
b. Restricted, repetitive patterns of behaviour, interests, or activities
c. Delay in language and cognitive development
d. Symptoms cause clinically significant impairment in social, occupational, or other important areas of current functioning”

A

C

“Nelsons 21st p295 Table 54.1 DSM-5 diagnostic criteria for autism spectrum disorder

A. Persistent deficits in social communication and social interaction across multiple contexts, as manifested by the following currently or in history:

  1. Deficits in social-emotional reciprocity
  2. Deficits in nonverbal communicative behaviors used for social interaction
  3. Deficits in developing, maintaining, and understanding relationships

B. Restricted, retptitive patterns of behavior, interests, and activites as manifested by at least 2 of the following, currently or by history

  1. Stereotyped or repetitive motor movements, use of objects, or speech
  2. Insistence on sameness, inflexible adherence to routines, or ritualized patterns of verbal or nonverbal behavior
  3. Highly restricted, fixated interests that are abnormal in intensity or focus
  4. Hyper- or hyporeactivity to sensory input or unusual interest in sensory aspects of the environment

C. Symptoms mye be present in the early developmental period (may not become fully manifest until social demands exceed limited capabilities, or may be masked by learned strategies in later life)

D. Symptoms cause clinically significant impairment in social, occupational, and other important areas or current functioning

E. These disturbances are not better explained by intellectual disability or global developmental delay”

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19
Q
"Parents brought their infant to the clinic. Her birthweight is 3kg. Now she weighs 6kg, laughs out loud, lifts head, able to roll to prone but cannot roll back to supine. At least how old is she?
A. 3 mos
B. 4 mos
C. 5 mos
D. 6 mos"
A

B

“Nelson 21st p134
Between 3 and 4 mo of age, the rate of growth slow to approximately 20g/day. By age 4mo, birthweight has doubled.

Nelson 21st p133 Table 22.2 Emerging patterns of behavior during the first year of life

3mo
Prone: Lifts head and chest with arms extended, head below the plane of body on ventral suspension
Supine: Tonic head posture predominates, reaches forward and misses objects; waves at toy
Sitting: Head lag partially compensated when pulled to a sitting position, early head control with bobbing motion, back rounded
Reflex: Typical moro reponse has not persistence, makes defensive movements or selective withdrawal reactions

4mo
Prone: Lifts head and chest, with head in approximately vertical axis, legs extended
Supine: Symmetric posture predominates, hands at midline, reaches and grasps objects and brings them to mouth
Sitting: No head lag when pulled to sitting position, head stedy, tipped forward, enjoys sitting with full truncal support
Standing: When held erect, pushes with feet
Adaptive: Sees raisin, but makes no more to reach for it
Social: Laughs out loud, may show displeasure when social contact is broken, excited at sight of food

7mo
Prone: Rolls over, pivots, crawls or creep-crawls
Supine: Lifts head, rolls over, squirms
Sitting: Sits briefly, with support of pelvis, leans forward on hands, back rounded
Standing: May support most of weight, bounces actively
Adaptive: Reaches out for and grasps large object, transfers object from hand to hand, grasp uses radial palm, rakes at raisin
Language: Forms polysyllabic vowel sounds
Social: Prefers mother, babbles, enjoys mirror, responds sto changes in emotional content of social contact “

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20
Q
"When is the earliest to have dental check up for carries.
A.12 mos
B. 15 mos
C. 18 mos
D. 24 mos"
A

A

“Prev Ped 2018 p11
The first dental visit is recommended to be done at the time of eruption of the first tooth and no later than 12 months of age.

During the first dental visit, the dentist will assess

  1. The child’s general health, growth, and behavior
  2. The child’s oral hygiene and periodontal health
  3. The risk for developing oral disease

The dentist will likewise provide education on infant oral health and evaluate and optimize flouride exposure. “

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21
Q
"Most common cause of death in all ages including children, adol, and even less than 1 yr old
A. Fires and burns
B. Drowning
C. Vehicular accidents
D. Suicide"
A

C

”"”Leading causes of pediatric death (US, 2016)

  1. Motor vehicle crashes
  2. Firearm-related injuries
  3. Malignant neoplasms
  4. Suffocation

Leading causes of pediatric death, Philippines (DOH, 2010)

Infant

  1. Bacterial sepsis
  2. Pneumonia
  3. Respiratory distress of newborn

Age 1-4

  1. Pneumonia
  2. Gastroenteritis
  3. Congenital anomalies

Age 5-9

  1. Pneumonia
  2. Dengue
  3. Drowning

Age 10-14

  1. Pneumonia
  2. Drowning
  3. Diseases of nervous system”””
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22
Q

“How many months should exclusive breastfeeding be recommended?

a) 4 months
b) 6 months
c) 8 months
d) 10 months”

A

B

“Nelson 21st p321
The AAP and WHO recommend that infants should be exclusively breastfed or given breast milk for 6mo. Breastfeeding should be continued with the introduction of complementary foods for 1 yr or longer, as mutually desired by mother and infant. “

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23
Q

“Introduction of lumpy foods should be done during this critical month. If it’s done beyond this month, there’s an increased risk for feeding difficulties.

a) 6 months
b) 8 months
c) 10 months
d) 12 months”

A

C

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24
Q

“Growth velocity of 6 year old boy is:

a) 6 cm/yr
b) 5 cm/yr
c) 4 cm/yr
d) 3 cm/yr”

A

A

“Growth milestones

0-2 months (Nelson 21st p132)
A newborn’s weight may initially decrease 10% (vaginal delivery) to 12% (caesarian section) below birthweight in the 1st wk as a result of excretion of excess extravascular fluid and limited nutritional intake.

Infants regain or exceed birthweight by 2wk of age and should grow at approximately 30g per day during the 1st mo.

2-6 months (Nelson 21st p134)
Between 3 and 4mo of age, the rate of growth slows to approximately 20g/day. By age 4mo, the birthweight is doubled

6-12 months (Nelsons 21st p135)
By the 1st birthday, birthweight has tripled, length has increased by 50%, and head circumference has increased by 10%.

12-18 months (Nelsons 21st p137)
Increase in head circumference of 2cm in 2nd year of life

18-24 months (Nelsons 21st p142)
Height and weight increase at a stead rate during this year, with a gain of 5in and 5lb. By 24mo, children are about half their ultimate adult height. Head growth slows slightly, with 85% of adult head circumference achieved by age 2yr, leaving only an additional 5cm gain over the next 2 years.

2-5 yr (Nelsons 21st p143)
Somatic and brain growth slows by the end of the 2nd year of life, with corresponding decreases in nutritional requirements and appetite, and the emergence of ““picky”” eating habits. Increases of approximately 2kg in weight and 7-8cm in height per year are expected.

Birthweight quadruples by 2.5 year of age. An average 4 year old weighs 40lb and is 40in tall. The head will only grow an additional 5-6cm between ages 3 and 18yr.

6-11 yr (Nelsons 21st p146)
Growth occurs discontinuously in 3-6 irregularly timed spurts per year, but varies both within and among individuals. Growth during the period average 3-3.5kg and 6-7cm per year. The head grows only 2cm in circumference throughout the entire period, reflecting a slowing of brain growth.

Nelsons 21st p151 Table 27.1 Growth velocity and other growth chracteristics by age

Infancy

  • Birth-12mo: 24cm/yr
  • 12-24mo: 10cm/yr
  • 24-36mo: 8cm/yr

Childhood

  • 6cm/yr
  • slowly decelerates before pubertal onset
  • height typically does not cross percentile lines

Adolescence

  • signoid shaped growth curve
  • adolescent growth spurt accounts for about 15% of adult height
  • peak height velocity for girls: 8cm/yr
  • peak height velocity for boys: 10cm/yr “
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25
Q

“This is the effortless regurgitation of food, with no nausea and retching.

a) Rumination
b) Regurgitation
c) Retching
d) Restitution”

A

B

“Nelson 21st p1904-1905
Regurgitation is the effortless movement of stomach contents into the esophagus and mouth. It is not associated with distress, and infants with regurgitation are often hungry immediately after an episode.

Regurgitation is a result of gastroesophageal reflux through an incompetent, or, in infants, immature lower esophageal sphincter. This is often a developmental process, and regurgitation, or ““spitting”” resolves with maturity. Regurgitation should be differentiated from vomiting, which denotes an active reflex process with an extensive differential diagnosis. “

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26
Q

“What is the most culturally sensitive developmental parameter?

a) Gross Motor
b) Fine motor
c) Language
d) Personal/Social”

A

D

“cultural sensitive - personal social
intelligence - language
combine motor and sensory - self help/adaptive”

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27
Q

“3yo with soiling of pants. What would you advise?

a) Observe, since it’s part of normal development
b) Refer to GI
c) Work up for chronic constipation
d) None of the above”

A

A

“Nelson 21st p1959
Encopresis is defined as voluntary or involuntary passage of feces into inappropriate places at least once a month for 3 consecutive months once a chronologic or developmental age of 4yr has been reached. Encopresis is not diagnosed when the behavior is exclusively the result of direct effects of a substance (e.g. laxatives) or a general medical condition (except through a mechanism involving constipation). “

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28
Q

“A child rolls over, utters polysyllabic vowel sounds, and sits with support.

a) 3 months
b) 4 months
c) 5 months
d) 6 months”

A

D

”"”Nelson 21st p134
Between 3 and 4 mo of age, the rate of growth slow to approximately 20g/day. By age 4mo, birthweight has doubled.

Nelson 21st p133 Table 22.2 Emerging patterns of behavior during the first year of life

3mo
Prone: Lifts head and chest with arms extended, head below the plane of body on ventral suspension
Supine: Tonic head posture predominates, reaches forward and misses objects; waves at toy
Sitting: Head lag partially compensated when pulled to a sitting position, early head control with bobbing motion, back rounded
Reflex: Typical moro reponse has not persistence, makes defensive movements or selective withdrawal reactions

4mo
Prone: Lifts head and chest, with head in approximately vertical axis, legs extended
Supine: Symmetric posture predominates, hands at midline, reaches and grasps objects and brings them to mouth
Sitting: No head lag when pulled to sitting position, head stedy, tipped forward, enjoys sitting with full truncal support
Standing: When held erect, pushes with feet
Adaptive: Sees raisin, but makes no more to reach for it
Social: Laughs out loud, may show displeasure when social contact is broken, excited at sight of food

7mo
Prone: Rolls over, pivots, crawls or creep-crawls
Supine: Lifts head, rolls over, squirms
Sitting: Sits briefly, with support of pelvis, leans forward on hands, back rounded
Standing: May support most of weight, bounces actively
Adaptive: Reaches out for and grasps large object, transfers object from hand to hand, grasp uses radial palm, rakes at raisin
Language: Forms polysyllabic vowel sounds
Social: Prefers mother, babbles, enjoys mirror, responds sto changes in emotional content of social contact “””

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29
Q

“In the multidisciplinary approach to ADHD, what is the 1st step?

a) Parental counseling
b) Undergo behavioral therapy
c) Refer to other subspecialties
d) None of the above”

A

A

“Nelson 21st p265
Once the diagnosis of ADHD has been established, the parents and child should be educated with regard to the ways ADHD can affect learning, behavior, self-esteem, social skills, and family function. The clinician should set goals for the family to help improve the child’s interpersonal relationships, develop study skills, and decreased disruptive behaviors. Parent support groups with appropriate professional consultation to such groups can be very helpful. “

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30
Q

“What is the most developed sense at birth?

a) Sight
b) Smell
c) Taste
d) Hearing”

A

D

“Nelson 21st p130
Soon after birth, neonates are alert and ready to interact and nurse. Neonates are nearsighted, having a fixed focal length of 8-12 inches, approximately the distance from the breast to the mother’s face, as well as an inborn visual preference for faces. Hearing is well-developed, and infants preferentially turn toward a female voice. “

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31
Q

“Mother consults in your clinic with 2 wk old baby. Can the baby recognize her?

a) can see and recognize
b) can’t see
c) can see to at least 20-30cm but can’t recognize
d) None of the above”

A

C

“Nelson 21st p130
Soon after birth, neonates are alert and ready to interact and nurse. Neonates are nearsighted, having a fixed focal length of 8-12 inches, approximately the distance from the breast to the mother’s face, as well as an inborn visual preference for faces. Hearing is well-developed, and infants preferentially turn toward a female voice. “

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32
Q

“After 2 years old, head circumference is less than chest circumference due to:

a) Closing of sutures and fontanelles
b) Faster growth of thoracic organs
c) Both of the above
d) None of the above”

A

B

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33
Q

“boy knows his name, age, sex. He says he will wash hands when given a cookie.

a) 2
b) 3
c) 5
d) 7”

A

B

“Nelson 21st p142 Table 23.1 Emerging patterns of behavior from 1-5yr of age

24 months / 2 years
Motor: Runs well, walks up and down stairs 1 step at atime, opens doors, climbs on furniture, jumps
Adaptive: Makes tower of 7 cubes (6 at 21mo), scribbles in circular pattern, imitates horizontal strokes, folds paper once imitatively
Language: Puts 3 words together (subject, verb, object)
Social: Handles spoon well, often tells about immediate experiences, helps to undress, listens to stories when shown pictures

30 months
Motor: Goes up stairs alternating feet
Adaptive: Makes tower of 9 cubes, makes vertical and horizontal strokes, but generally will not join them to make cross, imitates circular stroke, forming closed figure
Language: Refers to self by pronoun ““I””, knowns full name
Social: Helps put things away, pretends in play

36 months / 3 years
Motor: Rides tricycle, stands momentarily on 1 foot
Adaptive: Makes tower of 10 cubes, imitates construction of ““bridge”” of 3 cubes, copies circle, imitates cross
Language: Knows age and sex, counts 3 objects correctly; repeats 3 numbers or a sentence of 6 syllables, most of speech intelligible to strangers
Social: Plays simple games in parallel with other children, helps in dressing (unbuttons clothing and puts on shoes), washes hands

48 months / 4 years
Motor: Hops on 1 foot, throws ball overhand, uses scissors to cut out pictures, climbs well
Adaptive: Copies bridge from model, imitates construction of ““gate”” of 5 cybes, copies cross and square, draws man with 2-4 parts besides head, identifies longer of 2 lines
Language: Counts 4 pennies accurately, tells story
Social: Plays with several children, with beginning of social interaction and role playing, goes to toilet alone

60 months / 5 years
Motor: Skips
Adaptive: Draws triangle from copy, names heavier of 2 weights
Language: Names 4 colors, repeats sentence of 10 syllables, counts 10 pennies correctly
Social: Dresses and undresses, asks questions about meaning of words, engages in domestic roleplaying “

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34
Q

“Mechanism of heat loss in neonates except

a) convection of heat energy to the cooler surrounding air
b) conduction of heat to the colder materials touching the infant
c) cold radiation from the infant to other nearby cooler objects
d) evaporation from skin and lungs”

A

C

“Nelson 21st p872
The estimated rate of heat loss in a newborn is approximately 4 times that of an adult. Under normal delivery room conditions (20-25C), these rates generally result in a cumulative loss of 2-3C in deep body temperature (corresponding to a heat loss of approximately 200kcal/kg).

The heat loss occurs by 4 mechanisms

  1. Convection of heat energy to the cooler surrounding air
  2. Conduction of heat to the colder materials touching the infant
  3. Heat radiation from the infant to nearby cooler objects
  4. Evaporation from skin and lungs”
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35
Q

“A boy skips, hops, draws a triangle, dresses and undresses self. How old is he?

a) 3 years old
b) 4 years old
c) 5 years old
d) 6 years old”

A

C

”"”Nelson 21st p142 Table 23.1 Emerging patterns of behavior from 1-5yr of age

24 months / 2 years
Motor: Runs well, walks up and down stairs 1 step at atime, opens doors, climbs on furniture, jumps
Adaptive: Makes tower of 7 cubes (6 at 21mo), scribbles in circular pattern, imitates horizontal strokes, folds paper once imitatively
Language: Puts 3 words together (subject, verb, object)
Social: Handles spoon well, often tells about immediate experiences, helps to undress, listens to stories when shown pictures

30 months
Motor: Goes up stairs alternating feet
Adaptive: Makes tower of 9 cubes, makes vertical and horizontal strokes, but generally will not join them to make cross, imitates circular stroke, forming closed figure
Language: Refers to self by pronoun “”"”I””””, knowns full name
Social: Helps put things away, pretends in play

36 months / 3 years
Motor: Rides tricycle, stands momentarily on 1 foot
Adaptive: Makes tower of 10 cubes, imitates construction of “”"”bridge”””” of 3 cubes, copies circle, imitates cross
Language: Knows age and sex, counts 3 objects correctly; repeats 3 numbers or a sentence of 6 syllables, most of speech intelligible to strangers
Social: Plays simple games in parallel with other children, helps in dressing (unbuttons clothing and puts on shoes), washes hands

48 months / 4 years
Motor: Hops on 1 foot, throws ball overhand, uses scissors to cut out pictures, climbs well
Adaptive: Copies bridge from model, imitates construction of “”"”gate”””” of 5 cybes, copies cross and square, draws man with 2-4 parts besides head, identifies longer of 2 lines
Language: Counts 4 pennies accurately, tells story
Social: Plays with several children, with beginning of social interaction and role playing, goes to toilet alone

60 months / 5 years
Motor: Skips
Adaptive: Draws triangle from copy, names heavier of 2 weights
Language: Names 4 colors, repeats sentence of 10 syllables, counts 10 pennies correctly
Social: Dresses and undresses, asks questions about meaning of words, engages in domestic roleplaying “””

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36
Q

“Breastmilk storage period

a) Room temp of 30°c for 3hrs
b) Airconditioned room temp of 25°c for 6hrs
c) Refrigerator temp of 4°c for 8days
d) 2 door freezer for 6mos”

A

C

“Prev Ped 2018 p26

Breastmilk storage period

  1. Room temperature (<25C) - 4 hours
  2. Room temperature (>25C) - 1 hour
  3. Referigerator (4C) - 8 days
  4. Freezer compartment of a 1 door refrigerator - 2 weeks
  5. Freezer compartment of a 2 door refrigerator - 3 months
  6. Deep freezer with a constant temperature -20C - 6 months”
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37
Q

“Aside from weight for length, what is an accurate growth indicator?

a) BMI for age
b) weight for age
c) Length for age
d) Head circumference”

A

A

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38
Q

“Interpretation of z score above 3 for BMI for age?

a) Normal
b) at risk for overweight
c) Overweight
d) Obese”

A

D

“Prev Ped 2016 p33 Figure 3. Z score interpretation

Length/Height for age

  • Below -2: Stunted
  • Below -3: Severely stunted

Weight for age

  • Below -2: Underweight
  • Below -3: Severely underweight

Weight for length/height

  • Above 3: Obese
  • Above 2: Overweight
  • Above 1: Possible risk for overweight
  • Below -2: Wasted
  • Below -3: Severely wasted

BMI for age - Above 3: Obese

  • Above 2: Overweight
  • Above 1: Possible risk for overweight
  • Below -2: Wasted
  • Below -3: Severely wasted”
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39
Q

“Brain enlargement in the later years is due to:

a) Development of the sinuses
b) Increase in amount of cerebrospinal fluid
c) Brain myelinization
d) Increased mass of parietal and occipital bones”

A

C

“Nelson 21st p1017
Both structrual and functional brain development continue throughout adolescence. Cortical gray matter volume peaks in preadolescence then decreases because of selective pruning of rarely used synaptic connections. Cortical white matter volume increases until mid-late adolescence, reflecting increasing myelination and subsequent facilitation of integrated brain activity and more efficient transmission of information between different regions of the brain, enhancing the ““signal-to-noise”” ratio. “

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40
Q

“Brain growth is until what age?

a) 3 yo
b) 7 yo
c) 12 yo
d) 18yo”

A

D

”"”Nelson 21st p1017
Both structrual and functional brain development continue throughout adolescence. Cortical gray matter volume peaks in preadolescence then decreases because of selective pruning of rarely used synaptic connections. Cortical white matter volume increases until mid-late adolescence, reflecting increasing myelination and subsequent facilitation of integrated brain activity and more efficient transmission of information between different regions of the brain, enhancing the “”"”signal-to-noise”””” ratio. “””

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41
Q

“SMR3 pubic hair, SMR4 penis, with intense peer group involvement

a) Early Adolescence
b) Middle adolescence
c) Late adolescent
d) Late adulthood”

A

B

“Nelson 21st p1015 Table 132.1 Milestones in early, middle, and late adolescents

Physical
Early adolescents
- Females: secondary sex characteristics (breast, pubic, axillary hair), start of growth spurt
- Males: testicular enlargement, start of genital growth

Middle adolescents

  • Females: peak growth velocity, menarche
  • Males: growth spurt, secondary sex characteristics, nocturnal emissions, facial and body hair, voice changes
  • Changes in body composition, acne

Late adolescents

  • Physical maturation slows
  • Increased lean muscle mass in males

Peers
Early adolescents - same sex peer affiliations
Middle adolescents - Intense peer group involvement, preoccupation with peer culture, conformity
Late adolescents - peer group and values recede in importance “

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42
Q
"Infant that sits without support, babbles, crawls, prefers mother?
a. 5 months
b. 7 months
C. 10 months
d. 12 months"
A

C

“Nelson 21st p133 Table 22.2 Emerging patterns of behavior during the first year of life

7mo
Prone: Rolls over, pivots, crawls or creep-crawls
Supine: Lifts head, rolls over, squirms
Sitting: Sits briefly, with support of pelvis, leans forward on hands, back rounded
Standing: May support most of weight, bounces actively
Adaptive: Reaches out for and grasps large object, transfers object from hand to hand, grasp uses radial palm, rakes at raisin
Language: Forms polysyllabic vowel sounds
Social: Prefers mother, babbles, enjoys mirror, responds sto changes in emotional content of social contact

10mo
Sitting: Sits up alone and indefinitly without support
Standing: Pulls to sttanding position, cruises or walks holding on to furniture
Motor: Creeps or crawls
Adaptive: Graps objects with thumb and forefinger, pokes at things with forefinger, picks up pellet with assisted pincer movement, uncovers hidden toy, attempts to retrieve dropped object, releases object grasped by another person
Language: Repetitive consonant sounds (mama, dada)
Social: Responds to the sound of name, plays peek-a-boo or pat-a-cake, waves bye bye

1 yr
Motor: Walks with one hand held, rises independently, takes several steps
Adaptive: Picks up rasin with unassisted pincer movement of forefinger and thumb, releases object to other person on request or gesture
Language: Says a few words besides mama and dada
Social: Plays simple ball game, makes postural adjustment to dressing”

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43
Q

“What can a 4 year old do?

a. Dresses and undress
b. Tell a story
c. Stand on 1 foot moment arily
d. Copies a triangle”

A

B

”””””"”Nelson 21st p142 Table 23.1 Emerging patterns of behavior from 1-5yr of age

24 months / 2 years
Motor: Runs well, walks up and down stairs 1 step at atime, opens doors, climbs on furniture, jumps
Adaptive: Makes tower of 7 cubes (6 at 21mo), scribbles in circular pattern, imitates horizontal strokes, folds paper once imitatively
Language: Puts 3 words together (subject, verb, object)
Social: Handles spoon well, often tells about immediate experiences, helps to undress, listens to stories when shown pictures

30 months
Motor: Goes up stairs alternating feet
Adaptive: Makes tower of 9 cubes, makes vertical and horizontal strokes, but generally will not join them to make cross, imitates circular stroke, forming closed figure
Language: Refers to self by pronoun “”””””"”I””””””””, knowns full name
Social: Helps put things away, pretends in play

36 months / 3 years
Motor: Rides tricycle, stands momentarily on 1 foot
Adaptive: Makes tower of 10 cubes, imitates construction of “”””””"”bridge”””””””” of 3 cubes, copies circle, imitates cross
Language: Knows age and sex, counts 3 objects correctly; repeats 3 numbers or a sentence of 6 syllables, most of speech intelligible to strangers
Social: Plays simple games in parallel with other children, helps in dressing (unbuttons clothing and puts on shoes), washes hands

48 months / 4 years
Motor: Hops on 1 foot, throws ball overhand, uses scissors to cut out pictures, climbs well
Adaptive: Copies bridge from model, imitates construction of “”””””"”gate”””””””” of 5 cybes, copies cross and square, draws man with 2-4 parts besides head, identifies longer of 2 lines
Language: Counts 4 pennies accurately, tells story
Social: Plays with several children, with beginning of social interaction and role playing, goes to toilet alone

60 months / 5 years
Motor: Skips
Adaptive: Draws triangle from copy, names heavier of 2 weights
Language: Names 4 colors, repeats sentence of 10 syllables, counts 10 pennies correctly
Social: Dresses and undresses, asks questions about meaning of words, engages in domestic roleplaying “””””””

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44
Q

“What is the benefit of breastfeeding to the mother?

a. Decrease risk of endometrial and breast cancer
b. Decreases incidence of SIDS
c. Decrease incidence of cervical cancer
d. None of the above”

A

A

“Fundamentals of Pediatrics vol 1 p273-274 Table 14-2 Benefits of breastfeeding for the mother and the family

  1. Breastfeeding improves postpartum health - prevents prolonged bleeding from placental stimulation, prevents further anemia
  2. Breastfeeding hastens postpartum weight loss - larger reductions in weight and hip circumference in mothers who breastfeed compared to those who bottle feed
  3. Breastfeeding helps optimum child spacing - lactation amenorrhea
  4. Breastfeeding is affordable and convenient
  5. Breastfeeding prevents mothers from developing cancer - women who breastfeed have lower risks for breast and ovarian cancer
  6. Breastfeeing protects against bone and rheumatologic problems - protective against osteoporosis and rheumatoid arthritis “
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45
Q

“When is the best time to repair an undescended testes?

a. 3-6 months
b. 9- 12 months
c. 9-15 months
d. Before 24 months”

A

C

“Nelson 21st p2828
The congenital undescended testis should be treated surgically by 9-15 mo of age. With anesthesia by a pediatric anesthesiologist, surgical correction at 6 mo is appropriate, because spontaneous descent of the testis will not occur after 4 mo of age. Most testes can be brought down to the scrotum with an orchiopexy, which involves an inguinal incision, mobilization of the testis and spermatic cord, and correction of an indirect inguinal hernia.”

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46
Q

“True regarding adolescence?

a. Males enter puberty before females
b. Menarche is SMR 2
c. Boys will have 2 -3 years increase in length after females have stopped
d. None of the above”

A

C

“Nelson 21st p1014
In males the first visible sign of puberty and the hallmark of SMR 2 is testicular enlargement, beginning as early as 9.5yr, followed by the development of pubic hair. This is followed by penile growth during SMR 3. Peak growth occurs when testes volumes reach approximately 9-10cm3 during SMR 4.

In females, typically the first visible sign of puberty and the hallmark of SMR 2 is the appearance of breast buds (thelarche) between 7 and 12 yr of age. A significant minority of females develops pubic hair (pubarche) prior to thelarche. Menses typically begin within 3 yr of thelarche during SMR 3-4 (average age 12.5yr, normal range 9-15yr).

Females attain a peak height velocity of 8-9cm/yr at SMR 2-3, approximately 6mo before menarche. Males typically begin their growth acceleration at a later SMR stage, achieve a peak height velocity of 9-10cm later in the course of puberty (SMR 3-4), and continue their linear growth for approximately 2-3yr after females have stopped growing. “

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47
Q

What is the role of the parents regarding obesity in children

A

Parents should not use food as a reward …. increase physical activity with children, parents should be involved

“Nelson 21st p357 Table 60.8 Proposed suggestions for preventing obesity

Family

  • Eat meals aas a family in a fixed place and time
  • Do not skip meals, especially breakfast
  • Do not allow television during meals
  • Use small plates, keep serving dishes away from the table
  • Avoid unnecessary sweet or fatty foods and sugar-sweetened drinks
  • Remove televisions from children’s bedrooms, restrict times for TV viewing and video games
  • Do not use food as a reward”
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48
Q

“What is true regarding intellectual disability?

a. IQ of less than 80
b. Diagnosed before the age of 18
c. Able to take a bath and other stuff”

A

B

“Nelson 21st p283
Intellectual disability refers to a group of disorders that all include significant impairment in general intellectual function (reasoning, learning, problem solving), social skills, and adaptive behavior. Consistent among these definitions is onset of symptoms before age 18yr or adulthood

Significant impairment in general intellectual function refers to performance on an individually administered test of intelligence that is approximately 2 SD below the mean. Intelligence quotient (IQ) scores <70 would meet these criteria.

Significant impairment in adaptive behavior reflects the degree that the cognitive dysfunction impairs daily function. Adaptive behavior refers to the skills required for people to function in their everyday lives, addressing three broad sets of skills: conceptual, social, and practical. “

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49
Q

True regarding ADHD?

A

> 50% are achievers

“Nelson 21st p262
ADHD is the most common neurobehavioral disorder of childhood and among the most prevalent chronic health conditions affecting school-aged children.

ADHD is characterized by inattention, including increased distractability and difficulty sustaining attention; poor impulse control and decreased self-inhibitory capability; and motor overactivity and motor restlessness.

Affected children usually experience academic underachievement, problems with interpersonal relationships with family members and peers, and low self-esteem. “

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50
Q

“In a child with stuttering. Which is true?

a. Refer to therapist before preschool years for better outcome
b. Place the child in stress free environment
c. No need for special school
d. None of the above”

A

A

“Nelson 21st p281-282
Developmental stuttering is a childhood speech disorder that is not associated with stroke, traumatic brain injury, or other possible medical conditions and that interrupts the normal flow of speech through repeated or prolonged sounds, syllables, or single syllable words.

DSM-5 refers to this disorder as childhood onset fluency disorder, and impact on functional behavior is a component of the psychiatric diagnosis of this condition.

If there is a positive family history for stuttering, if symptoms are present for >4wk, and if the dysfluencies are impacting a child’s social, behavioral, and emotional functioning, referral is warranted. Although there is no cure for stuttering, behavioral therapies are available that are developed and implemented by speech and language pathologists.

Treatment in preschool age-children has been shown to improve stuttering. For school-age children, treatment includes not only improving fluency but also concommittants of the condition. This includes recognizing and accepting stuttering and appreciating others’ reaction to the child when stuttering, managing secondary behaviors, and addressing avoidance behaviors. “

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51
Q

“Interpret Weight for age - less than 3?

a. Severe stunting
b. Severe wasting
c. Severely underweight
d. Stunting”

A

C

“Prev Ped 2016 p33 Figure 3. Z score interpretation

Length/Height for age

  • Below -2: Stunted
  • Below -3: Severely stunted

Weight for age

  • Below -2: Underweight
  • Below -3: Severely underweight

Weight for length/height

  • Above 3: Obese
  • Above 2: Overweight
  • Above 1: Possible risk for overweight
  • Below -2: Wasted
  • Below -3: Severely wasted

BMI for age - Above 3: Obese

  • Above 2: Overweight
  • Above 1: Possible risk for overweight
  • Below -2: Wasted
  • Below -3: Severely wasted”
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52
Q

“Normal intelligence etc. but has a hard time reading.

a. Dyslexia
b. Dysarrthria
c. Dysphoria
d. Dysgraphia”

A

A

“Nelson 21st p267
The term dyslexia means an unexpected difficulty in reading for an individual who has the intelligence to be a much better reader, most commonly caused by a difficulty in the phonological processing (the appreciation of individual sounds of spoken language), which affects the ability of an individual to speak, read, and spell. “

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53
Q

“Mom frustrated because 2 year old child keeps using the left hand. She keeps telling him to use his right hand. What will you advise the mom?

a. Handedness is not established at this age
b. Train the child to use the right hand
c. Do not interfere with handedness
d. None of the above”

A

A

“Nelson 21st p143
Handedness is usually established by the 3rd yr. Fustration may result from attempts to change childrens’s hand preference. Variations in fine motor development reflect both individual proclivities and different opportunities for learning. Children who are restricted from drawing with crayons, for example, develop a mature pencil grasp later. “

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54
Q

“What to do with a 3 year old throwing temper tantrums in a toy store?

a. Ignore the child
b. Talk to the child and tell its wrong
c. Take child outside the store
d. Give the child a spanking”

A

A

“Nelson 21st p145
Control is a central issue. They are also prone to lose internal control, that is, to have temper tantrums. Fear, overtiredness, hunger, inconsistent expectations, or physical discomfort can also evoke tantrums. Tantrums normally appear toward the end of the 1st year of life and peak in prevalence between 2 and 4yr of age. Tantrums lasting more than 15min or regularly occuring more than 3x/day may reflect underlying medical, emotional, developmental, or social problems

Nelson 21st p241
The first key to office management of temper tantrums and breath holding spells is to help parents intervene before the child is highly distressed. The parent can be instructed to calmly remind the child of the expected behavior and the potential consequence if the expected behavior does not occur. If the child does not comply, he or she should be placed in time-out for a period approximating 1min for each year of age. Time out can be effectively used in children up to age 10 yr. Parents should also be advised to be mindful of their own reactions to the child’s tantrum behavior, to avoid an escalation of the child’s behavior caused by an angry parental response. “

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55
Q

“6 weeks old brought in the ER due to increased crying not previously noted. Good suck, Normal PE. What will you do/advise?

a. Colic, give spasmodic
b. Prone position
c. Normal for age
d. None of the above”

A

C

“Nelson 21st p136
Colic is characterized by the rule of 3. It occurs in a healthy, thriving infant beginning in the 2nd or 3rd week of life, lasts about 3 hr/day, occurs 3 days/wk, lasts more than 3wk, and resolved by 3 or 4 mo of age.

There is no specific treatment for colic, but practitioners should provide advice and reassurance to parents. Parents must be counseled about the problem, the importance of implementing a series of calm, systematic steps to soothe the infant, and having a plan for stress relief, such as time-out for parents and substitute caregivers. Parents can be advised that colic is self-limited and has no adverse effects on the child. The cause of colic is not known, and no medical intervention has been consistently effeective. “

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56
Q

“Adolescent came in with abnormal vaginal bleeding? Work up?

a. PT/PTT
b. Hgb/Hct
c. Liver function
d. Vaginal smear”

A

D

“Answer should be all of the above

Nelson p1060 Table 142.4 Laboratory tests to evaluate patients with abnormal uterine bleeding

  • Total and free testosterone (if with s/sx suggestive of PCOS)
  • Liver, kidney, and thyroid function studies
  • Complete blood count with platelet count
  • Urine pregnancy test
  • NAAT for Chlamydia, Gonorrhea, Trichomonas
  • PT/PTT
  • Ferritin level
  • VWB factor antigen, ristocetin cofactor, factor VIII activity
  • Pelvic UTZ (if bleeding persists despite treatment) “
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57
Q

“Red flag of gross motor development?

a. 3 months with headlag
b. 7 months unable to sit
c. 18 months cannot walk
d. None of the above”

A

B

“Prev Ped 2018 p19

Gross motor red flags
4 1/2 months - does not pull up to sit
5 months - does not roll over
7-8 months - does not sit without support
9-10 months - does not stand while holding on
15 months - not walking
2 years - not climbing up or down the stairs
2 1/2 years - not jumping with both feet
3 years - unable to stand on 1 foot momentarily
4 years - not hopping
5 years - unable to walk in a straight line back and forth or balance on 1 foot for 5-10 seconds “

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58
Q

“To prevent child abuse?

a. Screening of the family during check ups for risk factors
b. Pediatrician should limit developmental history during check ups
c. Both of the above
d. None of the above”

A

A

“Nelson 21st p106
Prevention of child abuse and neglect
1. Parent and child education regarding medical conditions helps to ensure the implementation of a the treatment plan and prevent neglect
2. Screening for major psychosocial risk factors for maltreatment (depression, substance abuse, intimate partner violence, major stress) and helping address identified problems, often through referrals, may help prevent maltreatment.
3. Child healthcare professionals should also need to recognize their limitations and facilitate referrals to other community resources.
4. The problems underpinning child maltreatment, such as poverty, parental stress, substance abuse, and limited child-rearing resources, require policies and programs that enhance families’ abilities to care for their children adequately”

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59
Q

BW of 3000g. BL of 49cm. HC of 34cm. Expected anthropometrics at 4 months

A

Weight of 5400g, length of 58cm, head circumference of 42cm.

“Fundamentals of pediatrics p122 Table 8-1 Useful mnemonic for common growth standards

Weight
0-6 months: age in months x 600 + birth weight (g)
6-12 months: 3600 + (age in months after 6 months x 500) + birth weight (g)
1-6 years: age in years x 2 + 8 (kg)
7-12 years: 1/2 [(age in years x 7) - 5)] (in kg)

Length
0-3 months: birth length + 9cm
4-6 months: birth length + 9cm + 8cm
7-9 months: birth length + 9cm + 8cm + 5cm
10-12 months: birth length + 9cm +8cm + 5cm + 3cm

Length/height
2-12 years: age in years x 6 + 77 (cm)

Mid-parental height
All ages, boys: 1/2 [(paternal + maternal height) + 13] (in cm)
All ages, girls: 1/2 [(paternal + maternal height) - 13)] (in cm) “

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60
Q

“Z score above 2 weight for height

a. Normal
b. Overweight
c. Obese”

A

B

“Prev Ped 2016 p33 Figure 3. Z score interpretation

Length/Height for age

  • Below -2: Stunted
  • Below -3: Severely stunted

Weight for age

  • Below -2: Underweight
  • Below -3: Severely underweight

Weight for length/height

  • Above 3: Obese
  • Above 2: Overweight
  • Above 1: Possible risk for overweight
  • Below -2: Wasted
  • Below -3: Severely wasted

BMI for age - Above 3: Obese

  • Above 2: Overweight
  • Above 1: Possible risk for overweight
  • Below -2: Wasted
  • Below -3: Severely wasted”
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61
Q
"A 3yo was not ed to have VA of 20/30, you tell the mother that VA of 20/20 will develop at
A. 4yo
B. 5yo
C. 6yo
D. 7yo"
A

A

“Nelson 21st p143
Visual acuity reaches 20/30 by age 3yr and 20/20 by age 4yr. “

62
Q

“Can ride a tricycle, throws ball, washes hands. Age?

a. 2 years old
b. 3 years old
c. 4 years old
d. 5 years old “

A

B

“Nelson 21st p142 Table 23.1 Emerging patterns of behavior from 1-5yr of age

24 months / 2 years
Motor: Runs well, walks up and down stairs 1 step at atime, opens doors, climbs on furniture, jumps
Adaptive: Makes tower of 7 cubes (6 at 21mo), scribbles in circular pattern, imitates horizontal strokes, folds paper once imitatively
Language: Puts 3 words together (subject, verb, object)
Social: Handles spoon well, often tells about immediate experiences, helps to undress, listens to stories when shown pictures

30 months
Motor: Goes up stairs alternating feet
Adaptive: Makes tower of 9 cubes, makes vertical and horizontal strokes, but generally will not join them to make cross, imitates circular stroke, forming closed figure
Language: Refers to self by pronoun ““I””, knowns full name
Social: Helps put things away, pretends in play

36 months / 3 years
Motor: Rides tricycle, stands momentarily on 1 foot
Adaptive: Makes tower of 10 cubes, imitates construction of ““bridge”” of 3 cubes, copies circle, imitates cross
Language: Knows age and sex, counts 3 objects correctly; repeats 3 numbers or a sentence of 6 syllables, most of speech intelligible to strangers
Social: Plays simple games in parallel with other children, helps in dressing (unbuttons clothing and puts on shoes), washes hands

48 months / 4 years
Motor: Hops on 1 foot, throws ball overhand, uses scissors to cut out pictures, climbs well
Adaptive: Copies bridge from model, imitates construction of ““gate”” of 5 cybes, copies cross and square, draws man with 2-4 parts besides head, identifies longer of 2 lines
Language: Counts 4 pennies accurately, tells story
Social: Plays with several children, with beginning of social interaction and role playing, goes to toilet alone

60 months / 5 years
Motor: Skips
Adaptive: Draws triangle from copy, names heavier of 2 weights
Language: Names 4 colors, repeats sentence of 10 syllables, counts 10 pennies correctly
Social: Dresses and undresses, asks questions about meaning of words, engages in domestic roleplaying “

63
Q
"Four 11-year old boys have a sleepover and were caught masturbating and with acts of self-exploration. How will you explain this to the parents?
A. Boys are homosexuals
B. Normal for early adolescents
C. Refer immediately to a psychiatrist
D. Strict disciplinary actions"
A

B

“Nelson 21st p1018
Early adolescents have increased sexual awareness and interest, which may manifest as sexual talk and gossip, and often is focused on sexual activity. Masturbation and other sexual exploration, sometimes with same-sex peers, are common. “

64
Q
"4 year old boy with increased clinginess to mother
A. Oral
B. Anal
C. Phallic
D. Latency"
A

C

“Nelson 21st p120 Table 18.2 Classic developmental stage theories

Freud - psychosexual
Erikson - psychosocial
Piaget - cognitive
Kohlberg - moral

Infancy (0-1yr)

  • Freud: oral
  • Erikson: basic trust vs mistrust
  • Piaget: sensorimotor

Toddlerhood (2-3yr)

  • Freud: anal
  • Erikson: autonomy vs shame and doubt
  • Piaget: sensorimotor
  • Kohlberg: preconventional - avoid punishment/obtain reward

Preschool (3-6yr)

  • Freud: phallic/oepedal
  • Erikson: initiative vs guilt
  • Piaget: operational
  • Kohlberg: conventional - conformity

School age (6-12yr)

  • Freud: latency
  • Erikson: industry vs inferiority
  • Piaget: concrete operations
  • Kohlberg: conventional - law and order

Adolescence (12-20yr)

  • Freud: genital
  • Erikson: identity vs role diffusion
  • Piaget: formal operations
  • Kolbherg: postconventional - moral principles “
65
Q

“Breast elevated as small mound, pubic hair straight media border of labia. Tanner Stage?

a. SMR 2
b. SMR 3
c. SMR 4
d. SMR 5”

A

A

“Nelson 21st p1015 Table 132.2 Sexual maturity rating stages in females

SMR 1

  • pubic hair: preadolescent
  • breasts: preadolescent

SMR 2

  • pubic hair: sparse, lightly pigmented, straight, medial border of labia
  • breasts: breast and papilla elevated as a small mound, diameter of areola increased

SMR 3

  • pubic hair: darker, beginning to curl, increased amount
  • breasts: breast and areola enlarged, no contour separation

SMR 4

  • pubic hair: coarse, curly, abundant but less than in adult
  • breasts: areola and papilla form secondary mound

SMR 5

  • pubic hair: adult feminine triangle, spread to medial surface of thighs
  • breasts: mature, nipple projects, areola part of general breast contour “
66
Q
"Period of development most affected by teratogens:
A. Fertilization of egg
B. Embryonic
C. Early fetal period
D. Late fetal period"
A

C

“Nelson 21st p128
For any potential fetal insult, the extent and nature of its effects are determined by the characteristics of the host as well as the dose and timing of the exposure. Organ systems are most vulnerable during periods of maximum growth and differentiation, generally during the first trimester (organogenesis) “

67
Q
"Expected height of a 13 year-old with birth length of 51cm.
A. 135cm
B. 145cm
C. 155cm
D. 165cm"
A

C

“(13 x 6) + 77 = 155cm

Fundamentals of Pediatric vol 1 p122 Table 8-1 Useful mnemonic for common growth standards

Weight
0-6 months: age in months x 600 + birth weight (g)
6-12 months: 3600 + (age in months after 6 months x 500) + birth weight (g)
1-6 years: age in years x 2 + 8 (kg)
7-12 years: 1/2 [(age in years x 7) - 5)] (in kg)

Length
0-3 months: birth length + 9cm
4-6 months: birth length + 9cm + 8cm
7-9 months: birth length + 9cm + 8cm + 5cm
10-12 months: birth length + 9cm +8cm + 5cm + 3cm

Length/height
2-12 years: age in years x 6 + 77 (cm)

Mid-parental height
All ages, boys: 1/2 [(paternal + maternal height) + 13] (in cm)
All ages, girls: 1/2 [(paternal + maternal height) - 13)] (in cm) “

68
Q

“True of separation anxiety
A. Attachment to one parent preferably mother
B. Being fussy when parents leaves the room
C. Use of a transitional object may be beneficial
D. All of the above”

A

D

“Nelson 21st p142
The relative independence of the previous half-year often gives way to increased clinginess at about 18mo. This stage, described as rapproachment, may be a reaction to growing awareness at the possibility of separation. Many parents report that they cannot go anywhere without having a small child attached to them. Separation anxiety will manifest at bedtime. Many children will use a special blanket or stuffed toy as a transitional object, which functions as a symbol of the absent parent. The transitional object remains important until the transition to symbolic thought has been completed and the symbolic presence of the parent fully internalized. “

69
Q

“True of enuresis:
A. Children with combined nocturnal and diurnal enuresis are more likely to have abnormalities of the urinary tract
B. Anatomic abnormalities are rarely associated with either nocturnal or diurnal enuresis such that invasive studies are generally contraindicated
C. Both of the above
D. None of the above”

A

C

70
Q

“Rotavirus vaccine is given in 2-3 doses, with the last dose to be given not later than this age

a. 5 months
b. 6 months
c. 8 months
d. 12 months “

A

C

“Prev Ped 2018 p70

Rotavirus vaccine

  • Given per orem
  • Given at a minimum age of 6 weeks with a minimum interval of 4 weeks between doses. The last dose should be administered not later than 32 weeks of age
  • The monovalent human rotavirus vaccine (RV1) is given as a 2 dose series and the pentavalent human bovine rotavirus vaccine (RV5) is given as a 3 dose series “
71
Q

“Minimum employable age in the Philippines

a. 13 years old
b. 15 years old
c. 16 years old
d. 18 years old “

A

B

“Philippine Labor Code (Presidential Decree No. 442 of 1974, as amended), Article 139

Article 139 governs the minimum working age and the employment of minors. The minimum working age is set at 15, except where the child works directly under the sole responsibility of their parent or guardian, and their employment does not interfere with their education.

The working hours of young workers between 15 and 18 years of age are determined by the Secretary of Labor and Employment. No person younger than 18 may perform work that is hazardous or detrimental in nature. “

72
Q
"Which will prevent early childhood caries:
A. Carbonated drinks
B. Bottle feeding
C. Breastfeeding
D. Fruit juices"
A

C

“Nelson 21st p1920-1921
The most effective preventive measure against dental caries is communal water supplies with optimal flouride content.

Dental brushing, especially with flouridated toothpaste, helps to prevent dental caries

Frequent consumption of sweetened fruit drinks is not generally recognized by parents for its cariogenic potential. Consuming sweetened beverages in a nursing bottle or sippy cup should be discouraged and special efforts made to instruct parents that their child should consume sweetened beverages only at meal times and not exceed 6oz/day

Plastic dental sealants have been shown to be effective at preventing caries on the pit and fissure of the primary and pernant molars. “

73
Q
"Preferred measurement of obesity in a 4 year-old child
A. MUAC
B. BMI
C. Weight for height
D. Weight for length"
A

B

“Nelson 21st p346
Obesity or increased adiposity is defined using the body mass index, an excellent proxy for more direct measurement of body fat. During childhood, levels of body fat change beginning with high adiposity during infancy. Body fact levels decrease for approximately 5.5 yr until the period called adiposity rebound, when body fat is typically at the lowest level. Adiposity then increases until early adulthood.

Consequently, obesity and overweight are defined using BMI percentiles for children >=2 yr old and weight/length percentiles for infants <2 yr old. The criterion for obesity is BMI >= 95th percentile and for overweight is BMI between 85th and 95th percentiles. “

74
Q

Main purpose of medical clearance/certificate for school entrant

A

IDENTIFY HIGH RISK POPULATION IN THE STUDENT BODY

75
Q

“Which nutrient is found to have a role in decreasing the duration and severity of diarrhea

a. Vitamin A
b. Ascorbic acid
c. Zinc
d. Vitamin D “

A

C

“Nelson 21st p2029
Zinc supplementation in children with diarrhea in developing countries leads to reduced duration and severity of diarrhea and could potentially prevent a large proportion of cases from recurring.

All children older than 6mo of age with acute diarrhea in at-risk areas should recieve oral zinc (20mg/day) in some form for 10-14 days during and continued after diarrhea. “

76
Q
"A child had multiple metaphyseal fractures, left for care by parents with teenager who took alcohol. Based on PE findings, what does this manifest?
A. Neglect
B. Child abuse 
C. Both of the above 
D. None of the above"
A

B

“Nelsons 21st p101
Fractures that strongly suggest abuse include classic metaphyseal lesions, posterior rib fractures, and fractures of the scapula, sternum, and spinous processes, especially in young children. These fracture all require more force that would be expected from a minor fall or routine handling and activities of a child.

In abused infants, rub, metaphyseal, and skull fractures are most common. Femoral and humeral fractures in nonambulatory infants are also very worrisome for abuse. With increasing mobility and running, toddlers can fall with enough rotational force to cause a spiral femoral fracture. Multiple fractures in various stages of healing are suggestive of abuse.

Clavicular, femoral, supracondylar, humeral, and distal extremity fractures in children older than 2 yr are most likely noninflicted unless they are multiple or accompanied by other signs of abuse. “

77
Q
"A child with malnutrition, dirty nails, shabby clothes, unkempt etc.
A. Neglect
B. Abuse
C. Both of the above
D. None of the above"
A

A

“Nelson 21st p99
Neglect refers to omissions in care, resulting in actual or potential harm. Omissions include inadequate healthcare, education, supervision, protection from hazards in the environment, and unmet physical needs (e.g. food, clothing) and emotional support.

A preferable aternative to focusing on caregiver omissions is to instead consider the basic needs (or rights) of children (e.g. adequate food, clothing, shelter, healthcare, education, nurturance). Neglect occurs when a need is not adequately met and results in physical harm, whatever the reasons.

A child whose helath is jeopardized or harmed by not recieving necessary care experiences medical neglect. “

78
Q

How is lead toxicity measured?

A

Blood lead level

“Nelson 21st p3799
Until 1997, universal screening by blood lead testing of all children ages 12 and 24mo was the standard in the United States. Given the national decline in the prevalence of lead poisoning, the recommendations have been revised to target blood lead testing of high risk populations. “

79
Q

Micronutrient usually given for patients with measles and those with dry scaly hyperkeratotic patches, diarrhea, anemia

A

Vitamin A

80
Q

Mother has a child with meningocele. What advise can you give to the mother for the next pregnancy?

A

Take folic acid

“Nelson p3066-3067
All women of childbearing age who can become pregnant should take 0.4mg folic acid daily. If, however, a pregnancy is planned in high risk women (previously affected child), supplementation should be started with 4mg of folic acid daily, beginning 1mo before the time of the planned conception. “

81
Q
"The prevalence and amount of dental caries in an individual is obtained by calculating the number of DMFT which stands for:
A. Decayed, missing, filled, teeth
B. Diseased, missing, fluorosis, teeth
C. Diseased, missing, filled, teeth
D. None of the above"
A

A

82
Q

“Least at risk for psychosomatic complaints

a. Mother with illness
b. Children from lower socioeconomic status
c. Children with behavioural problems
d. Child with siblings who are achievers and under peer pressure”

A

B

“Nelson 21st p202-203
Risk factors for psychosomatic symptoms

Individual

  1. Temperament/Coping styles - more common in children who are conscientious, sensitive, insecure, internalizers, and anxious, and in those who strive for high academic achievement. Somatization may also occur in children who are unable to verbalize emotional distress
  2. Learned behavior - Somatic complaints may be reinforced through a decrease in responsibilities or expectations by other and through recieving attention and sympathy
  3. Psychiatric comorbidity - e.g. depressive and anxiety disorders
  4. Childhood physical illness - history of previous physical illness

Family and Environmental

  1. Symptom modeling - A significant proportion of patient with SSRD had recently encountered similar symptoms in their environment or live with family members who complain of similar physical symptoms (e.g. child with nonepileptic seizures who has parent or sibling with seizure disorder)
  2. Parental Responses - Parental beliefs about the significance of symptoms influence the extent of symptoms the child reports
  3. School and family stressors - Common stressors include bullying, beginning the school year, fear of academic failure, participation in extracurricular activities, dysfunction and less support within the family system, transition within the family system
  4. Trauma - e.g. sexual, physical, emotional abuse
  5. Genetic and biologic variabilities - e.g. increased pain sensitivity”
83
Q

“Reaction of 2 month old to a ball that fell

a. Infant will cry once the ball hits the floor
b. Infant will follow the ball as it falls
c. Infant will transiently look at the spot where the ball fell
d. Infant will actively look for the ball”

A

B

“Nelson 21st p133 Table 22.2 Emerging patterns of behavior during the first year of life

Neonatal period (1st 4wk)
Prone: lies in flexed attitude, turns head from side to side, head sags on ventral suspension
Supine: generally flexed and a little stiff
Visual: may fixate on face on light and in line of vision; dolls eye movement (oculocephalic reflex) of eyes on turning of body
Reflex: Moro response active, stepping and placing reflexes, grasp reflex active
Social: visual preference for human face

1mo
Prone: legs more extended, holds chin up, turns head; head lifted momentarily to plane of body on ventral suspension
Supine: tonic neck posture predominates, supple and relaxed, head lags when pulled to sitting position
Visual: watches person, follows moving object
Social: body movements in cadence with voice of other in social contact, beginning to smile

2mo
Prone: raises head slightly further; head sustained in plane of body on ventral suspension
Supine: tonic neck posture predominates; head lags when pulled to sitting position
Visual: follows moving object 180 degrees
Social: smiles on social contact, listens to voice and coos”

84
Q

“A female adolescent with breast and papilla as small mound, pubic hair sparse lightly pigmented. What is the Tanner stage?

a. SMR 1
b. SMR 2
c. SMR 3
d. SMR 4”

A

B

”"”Nelson 21st p1015 Table 132.2 Sexual maturity rating stages in females

SMR 1

  • pubic hair: preadolescent
  • breasts: preadolescent

SMR 2

  • pubic hair: sparse, lightly pigmented, straight, medial border of labia
  • breasts: breast and papilla elevated as a small mound, diameter of areola increased

SMR 3

  • pubic hair: darker, beginning to curl, increased amount
  • breasts: breast and areola enlarged, no contour separation

SMR 4

  • pubic hair: coarse, curly, abundant but less than in adult
  • breasts: areola and papilla form secondary mound

SMR 5

  • pubic hair: adult feminine triangle, spread to medial surface of thighs
  • breasts: mature, nipple projects, areola part of general breast contour “””
85
Q

“Peak growth in boys occurs in what Tanner stage?

a. SMR 3
b. SMR 4
c. SMR 5
d. None of the above”

A

B

“Nelson 21st p1014
Females attain a peak height velocity of 8-9cm/yr at SMR 2-3, approximately 6mo before menarche. Males typically begin their growth acceleration at a later SMR stage, achieve a peak height velocity of 9-10cm later in the course of puberty (SMR 3-4), and continue their linear growth for approximately 2-3yr after females have stopped growing. “

86
Q

“What would a 15 year adolescent will most likely tell you?

a. ““Why is everyone staring at me?””
b. ““I would like to be a doctor someday””
c. ““Why is my nose this big?””
d. ““I am good at sports”””

A

C

“Choice A: Early adolescence (self-consicousness about appearance and attractiveness
Choice B: Late adolescence (future-oriented with sense of perspective)
Choice D: Late adolescence (consolidation of identity(

Nelson 21st p1015 Table 132.1 Milestones in early, middle, and late adolescent development

Middle adolescence (14-17yr)

Cognitive and moral

  • Emergence of abstract thought (formal operations)
  • May perceive future implications, but may not apply in decision-makring
  • Strong emotions may drive decision-making
  • Sense of invulnerability
  • Growing ability to see others’ perspectives

Self-concept / identity formation

  • Concern with attractiveness
  • Increasing introspection

Family

  • Conflicts over control and independence
  • Struggle for greater autonomy
  • Increased separation from parents

Peers

  • Intense peer group involvement
  • Preoccupation with peer culture, conformity

Sexual

  • Testing ability to attract partner
  • Initiation of relationships and sexual activity
  • Exploration of sexual identity “
87
Q

“2-year-old …Height for Age Zscore is below -2 and Weight for Height Z score is below -2.

a. Stunted and under weight
b. Severely stunted and severely wasted
c. Stunted and wasted”

A

C

“Prev Ped 2016 p33 Figure 3. Z score interpretation

Length/Height for age

  • Below -2: Stunted
  • Below -3: Severely stunted

Weight for age

  • Below -2: Underweight
  • Below -3: Severely underweight

Weight for length/height

  • Above 3: Obese
  • Above 2: Overweight
  • Above 1: Possible risk for overweight
  • Below -2: Wasted
  • Below -3: Severely wasted

BMI for age - Above 3: Obese

  • Above 2: Overweight
  • Above 1: Possible risk for overweight
  • Below -2: Wasted
  • Below -3: Severely wasted”
88
Q
"What is the expected weight in kg of an 8-month old male:
A. 5
B. 6
C. 7
D. 8"
A

D

”"”3600 + (2x500) + 3400 = 8000 = 8kg

Fundamentals of pediatrics p122 Table 8-1 Useful mnemonic for common growth standards

Weight
0-6 months: age in months x 600 + birth weight (g)
6-12 months: 3600 + (age in months after 6 months x 500) + birth weight (g)
1-6 years: age in years x 2 + 8 (kg)
7-12 years: 1/2 [(age in years x 7) - 5)] (in kg)

Length
0-3 months: birth length + 9cm
4-6 months: birth length + 9cm + 8cm
7-9 months: birth length + 9cm + 8cm + 5cm
10-12 months: birth length + 9cm +8cm + 5cm + 3cm

Length/height
2-12 years: age in years x 6 + 77 (cm)

Mid-parental height
All ages, boys: 1/2 [(paternal + maternal height) + 13] (in cm)
All ages, girls: 1/2 [(paternal + maternal height) - 13)] (in cm)”””

89
Q
"What is the expected head circumference in cm of a 1-year old female whose head circumference at birth is 34cm?
A. 36
B. 37
C. 38
D. 39"
A

*12 cm in 1 year= 46

90
Q
"At what age in months do the Moro, asymmetric tonic neck & tonic labyrinthine reflexes usually disappear?
A. 2
B. 3
C. 4
D. 5"
A

D

“Nelsons 21st p3059 Table 608.2 Timing of selected primitive reflexes

Palmar grasp

  • onset 28 wk AOG
  • fully developed 32 wk AOG
  • duration 2-3mo postnatal

Rooting

  • onset 32wk AOG
  • fully developed 36wk AOG
  • less prominent after 1 mo postnatal

Moro

  • onset 28-32wk AOG
  • fully developed 37wk AOG
  • duration 5-6mo postnatal

Tonic neck

  • onset 35wk AOG
  • full developed 1 mo postnatal
  • duration 6-7 mo postnatal

Parachute

  • onset 7-8mo postnatal
  • fully developed 10-11mo postnatal
  • remains throughout life “
91
Q
"At what age in months can a child hop on one foot, imitate a cross, put on buttons & describe feelings such as fatigue and/ or anger?
A. 36
B. 42
C. 48
D. 54"
A

C

”"”Nelson 21st p142 Table 23.1 Emerging patterns of behavior from 1-5yr of age

24 months / 2 years
Motor: Runs well, walks up and down stairs 1 step at atime, opens doors, climbs on furniture, jumps
Adaptive: Makes tower of 7 cubes (6 at 21mo), scribbles in circular pattern, imitates horizontal strokes, folds paper once imitatively
Language: Puts 3 words together (subject, verb, object)
Social: Handles spoon well, often tells about immediate experiences, helps to undress, listens to stories when shown pictures

30 months
Motor: Goes up stairs alternating feet
Adaptive: Makes tower of 9 cubes, makes vertical and horizontal strokes, but generally will not join them to make cross, imitates circular stroke, forming closed figure
Language: Refers to self by pronoun “”"”I””””, knowns full name
Social: Helps put things away, pretends in play

36 months / 3 years
Motor: Rides tricycle, stands momentarily on 1 foot
Adaptive: Makes tower of 10 cubes, imitates construction of “”"”bridge”””” of 3 cubes, copies circle, imitates cross
Language: Knows age and sex, counts 3 objects correctly; repeats 3 numbers or a sentence of 6 syllables, most of speech intelligible to strangers
Social: Plays simple games in parallel with other children, helps in dressing (unbuttons clothing and puts on shoes), washes hands

48 months / 4 years
Motor: Hops on 1 foot, throws ball overhand, uses scissors to cut out pictures, climbs well
Adaptive: Copies bridge from model, imitates construction of “”"”gate”””” of 5 cybes, copies cross and square, draws man with 2-4 parts besides head, identifies longer of 2 lines
Language: Counts 4 pennies accurately, tells story
Social: Plays with several children, with beginning of social interaction and role playing, goes to toilet alone

60 months / 5 years
Motor: Skips
Adaptive: Draws triangle from copy, names heavier of 2 weights
Language: Names 4 colors, repeats sentence of 10 syllables, counts 10 pennies correctly
Social: Dresses and undresses, asks questions about meaning of words, engages in domestic roleplaying “””

92
Q
"Gender identity is generally fixed at what age in years?
A. 1
B. 2
C. 4
D. 5"
A

B

“Nelson 21st p1021
Gender identity develops early in life and is generally fixed by 2-3 yr of age. Children first learn to identify their own and others’ sex (gender labeling), then learn that gender is most often stable over time (gender constancy), and finally learn that gender is typically permanent (gender consistency). What determines gender identity is largely unknown, but it is thought to be an interaction of biologic, environmental, and sociocultural factors. “

93
Q
"At what age in months are the two hallmarks of development- locomotion & stranger anxiety, evident?
A. 2
B. 4
C. 7
D. 9"
A

D

“Nelson 21st p135 6-12 months
Physical development
Many infants begin crawling and pulling to stand around 8mo, followed by cruising. Some walk by 1 year. These gross motor skills expand infants’ exploratory range and create new physical dangers, as well as opportunities for learning.

Emotional development
The advent of object permanence (9mo) corresponds with qualitative changes in social and communicative development. Infants look back and forth between an approaching stranger and a parent and may cling or cry anxiously, demonstrating stranger anxiety. “

94
Q
"Which of the following features is considered a more dramatic sign of maturation among males during middle childhood?
A. Hypertrophy of the lymphoid tissues
B. Increase in muscular strength
C. Loss of deciduous teeth
D. Growth of the midface & lower face"
A

C

“Nelson 21st p146
Growth of the midface and lower face occurs gradually, loss of deciduous (baby) teeth is a more dramatic sign of maturatin, beginning at around 6yr of age. Replacement with adult teeth occurs at a rate of around 4 per year, so that by 9yr of age, children will have 8 permanent incisors and 4 permanent molars. Premolars erupt by 11-12 yr of age. Lymphoid tissues hypertrophy and reach maximal size, often giving rise to impressive tonsils and adenoids. “

95
Q

“A 5-year old boy consulted because of development al delay. He was born full term via NSD with APGAR scores of 4, 6 &
8. The physical & neurologic examinations were unremarkable. On developmental evaluation, he was able to creep upstairs & run short distances, imitate vertical & circular strokes, utter at least 10 words with meaning, & remove his shorts. What is his approximate developmental age in months?
A. 24
B. 36
C. 48
D. 60”

A

B

”"”Nelson 21st p142 Table 23.1 Emerging patterns of behavior from 1-5yr of age

24 months / 2 years
Motor: Runs well, walks up and down stairs 1 step at atime, opens doors, climbs on furniture, jumps
Adaptive: Makes tower of 7 cubes (6 at 21mo), scribbles in circular pattern, imitates horizontal strokes, folds paper once imitatively
Language: Puts 3 words together (subject, verb, object)
Social: Handles spoon well, often tells about immediate experiences, helps to undress, listens to stories when shown pictures

30 months
Motor: Goes up stairs alternating feet
Adaptive: Makes tower of 9 cubes, makes vertical and horizontal strokes, but generally will not join them to make cross, imitates circular stroke, forming closed figure
Language: Refers to self by pronoun ““I””, knowns full name
Social: Helps put things away, pretends in play

36 months / 3 years
Motor: Rides tricycle, stands momentarily on 1 foot
Adaptive: Makes tower of 10 cubes, imitates construction of ““bridge”” of 3 cubes, copies circle, imitates cross
Language: Knows age and sex, counts 3 objects correctly; repeats 3 numbers or a sentence of 6 syllables, most of speech intelligible to strangers
Social: Plays simple games in parallel with other children, helps in dressing (unbuttons clothing and puts on shoes), washes hands

48 months / 4 years
Motor: Hops on 1 foot, throws ball overhand, uses scissors to cut out pictures, climbs well
Adaptive: Copies bridge from model, imitates construction of ““gate”” of 5 cybes, copies cross and square, draws man with 2-4 parts besides head, identifies longer of 2 lines
Language: Counts 4 pennies accurately, tells story
Social: Plays with several children, with beginning of social interaction and role playing, goes to toilet alone

60 months / 5 years
Motor: Skips
Adaptive: Draws triangle from copy, names heavier of 2 weights
Language: Names 4 colors, repeats sentence of 10 syllables, counts 10 pennies correctly
Social: Dresses and undresses, asks questions about meaning of words, engages in domestic roleplaying “””

96
Q
"What is the first visible sign of puberty in females?
A. Growth of genital hair
B. Beginning of menstruation
C. Appearance of breast buds
D. Growth acceleration"
A

C

”"”Nelson 21st p1014
In males the first visible sign of puberty and the hallmark of SMR 2 is testicular enlargement, beginning as early as 9.5yr, followed by the development of pubic hair. This is followed by penile growth during SMR 3. Peak growth occurs when testes volumes reach approximately 9-10cm3 during SMR 4.

In females, typically the first visible sign of puberty and the hallmark of SMR 2 is the appearance of breast buds (thelarche) between 7 and 12 yr of age. A significant minority of females develops pubic hair (pubarche) prior to thelarche. Menses typically begin within 3 yr of thelarche during SMR 3-4 (average age 12.5yr, normal range 9-15yr).

Females attain a peak height velocity of 8-9cm/yr at SMR 2-3, approximately 6mo before menarche. Males typically begin their growth acceleration at a later SMR stage, achieve a peak height velocity of 9-10cm later in the course of puberty (SMR 3-4), and continue their linear growth for approximately 2-3yr after females have stopped growing. “””

97
Q
"A male noted that his pubic hair became darker & started to curl, his penis was longer, & his testes were larger. What is his sexual maturity rating?
A. 2
B. 3
C. 4
D. 5"
A

B

“Nelson 21st p1015 Table 132.3 Sexual maturity rating stages in males

SMR 1

  • pubic hair: none
  • penis: preadolescent
  • testes: preadolescent

SMR 2

  • pubic hair: scant, long, slightly pigmented
  • penis: minimal change/enlargement
  • testes: enlarged scrotum, pink, texture altered

SMR 3

  • pubic hair: darker, starting to curl, small amount
  • penis: lengthens
  • testes: larger

SMR 4

  • pubic hair: resembles adult type byt less quantity, coarse, curly
  • penis: larger, glans and breadth increase in size
  • testes: larger, scrotum dark

SMR 5

  • pubic hair: adult distribution, spread to medial surface of thighs
  • penis: adult size
  • testes: adult size “
98
Q

“Which of the following statements is TRUE of early adolescence?
A. Consolidation of sexual identity occurs.
B. There is a continuous struggle for acceptance of greater autonomy.
C. There is ambivalence as well as bids for increased independence.
D. There are increased sexual drives/ urges with experimentation & questions about sexual orientation .”

A

C

“Nelson 21st p1015 Table 132.1 Milestones in early, middle, and late adolescent development

Early adolescence (10-13yr)

Cognitive and moral

  • concrete operations
  • egocentricity
  • unable to percieve long-term outcome of current decisions
  • follow rules to avoid punishment

Self-concept/identity formation

  • preoccupied with changing body
  • self-consciousness about appearance and attractiveness

Family

  • increased need for privacy
  • exploration of boundaries of dependence vs independence

Peers
- same sex peer affilications

Sexual

  • increased interest in sexual anatomy
  • anxieties and questions about pubertal changes
  • limited capacity for intimacy “
99
Q

“16-year old male, your regular patient since school-age, came for his annual adolescent check-up. As part of the adolescent health care, which of the following tasks is NOT necessary?
A. Tanner staging
B. Complete blood count
C. Examination of the spine to checking for scoliosis
D. Complete history taking (HEEADSSS)”

A

B

“CBC not necessary since the patient has been your regular patient since school-age and presumably has had his CBC for middle adolescence at his annual checkup at 14 years old.

Prev Ped 2018 p16
During the annual visit, the adolescent should undergo the following:

  1. Complete history-taking to screen for risks and protective factors using the tool HEEADSSS
  2. Physical examination. In addition to the routine physical examinatinon, the following should be done:
    - Tanner staging/SMR
    - breast examination
    - examination of the spine and shoulders, check for scoliosis and kyphosis
    - inspection of the genitals and anus
  3. Screening procedures
    - CBC at every stage of adolesence
    - UA on first encounter
    - Vaginal wet mount, PAP smear for sexually active females
    - Serologic test for syphilis for sexually active males, nonculture test for gonorrhea and chlamydia for sexually active males and females
  4. Immunization update
  5. Anticipatory guidance and counseling
    - Self breast examination for females
    - healthy lifestyle: physical activity, diet, avoidance of alcohol, smoking, drug abuse
    - sexual behavior and risk of acquiring STIs
    - injury and accident prevention: use of sports protetive gear, seat belts, no driving under the influence of alcohol, no smoking in bed, no hand gun use
100
Q
"2-year old female came to the OPD to update her immunizations. She has received 3 doses each of Hepatitis B, DPT, IPV, HiB & PCV13, & 1 dose each of measles, varicella & MMR. Which of the following vaccines should be given?
A. Varicella
B. DPT/IPV/ HiB
C. MMR
D. Rotavirus"
A

B

“Priority is to give DTP 4th dose.

Prev Ped 2018 p70-71

Varicella Vaccine

  • given subcutaneously
  • given at a minimum age of 12 months
  • 2 doses of varicella vaccine are recommended
  • the 2nd dose is usually given at 4-6 years of age, but may be given earlier at an interval of 3 months from the 1st dose
  • if the 2nd dose was given 4 weeks from the 1st dose, it is considered valid
  • for children 13 years old and above, the recommeneded minimum interval between doses is 4 weeks

MMR vaccine

  • given subcutaneously
  • given at a minimum age of 12 months
  • 2 doses of MMR vaccine are recommended
  • the 2nd dose is usually given from 4-6 years of age, but may be given at an earlier age with a minimum 4 weeks interval between doses

Rotavirus

  • given per orem
  • given at a minimum age of 6 weeks with a minimum interval of 4 weeks between doses; the last dose should be administered not later than 32 weeks of age

Diphtheria and tetanus toxoid and pertussis vaccine (DTP)

  • given intramuscularly
  • given at a minimum age of 6 weeks with a minimum interval of 4 weeks
  • complete a 5 dose seires at ages 2, 4, 6, 15 through 18 months, and 4 through 6 years; the recommended interval between the 3rd and 4th dose is 6 months, but a minimum interval of 4 months is valid
  • the 5th dose of DTaP vaccine may not be given if the 4th dose was administered at age 4 years or older”
101
Q

“Who among the following patients can be dewormed?
A. A 4-year old female with weight-for-height below -3 z score
B. A toddler with a 2-day history of fever (39.3oC)
C. A school -aged child with profuse diarrhea
D. An 8-year old male who was hospitalized last week with pneumonia”

A

D

“Prev Ped 2018 p10-11
The WHO and DOH both recommend the use of either albendazole or mebendazole in the following doses and schedule

Albendazole
12-23 months: 200mg SD every 6 months
24 months and above: 400mg SD every 6 months

Mebendazole
12 months and above: 500mg SD every 6 months

Deworming must not be done in children with the following:

  • severe malnutrition
  • high grade fever
  • profuse diarrhea
  • abdominal pain
  • serious illness
  • previous hypersensitivity to antihelminthic drug “
102
Q

“A mother brought her 1 year old son to the clinic because she is concerned that he cannot walk independently. She
further disclosed that her first child, who is now an adolescent, was able to walk at one year of age which further adds to her anxiety. What is the appropriate next step?
A. Refer the child to a physical therapist
B. Investigate the cause of delay in the motor development
C. Tell her it is normal & observe if he is still unable to walk by 18 months of age
D. Explain that her first child had advanced gross motor development while the second child has delayed fine motor skills”

A

C

“Gross motor red flag for not walking is 15 months (Prev Ped 2018 p19) or 18 months (Nelsons 21st p 158 Table 28.2)

Prev Ped 2018 p19
As children grow and develop, one needs to be mindful that each child develops at his/her own pace and the range of what is considered to be ““normal”” is quite wide. However, there are absolute indicators often referred to as red flags that identify developmental markers suggesting the need for further neurodevelopmental evaluation”

103
Q
"At what age in years should routine blood pressure measurement in a well child start?
A. 1
B. 3
C. 5
D. 7"
A

B

“Prev Ped 2018 p7
The Pediatric Nephrology Society of the Philippines recommends routine BP measurement annualy for all children >3 years of age and adolescents. BP however should also be checked in every encounter on all ill patients and all patients at risk such as those with obesity, those taking medications known to increase BP, those with renal disease, history of aortic arch obstruction, diabetes. “

104
Q
"Delayed puberty in males is the absence of pubertal development at what age in years?
A. 10
B. 12
C. 14
D. 16"
A

C

“Nelson 21st p2907
Delayed puberty is a failure of development of any pubertal feature by 13 yr of age in females and 14 yr of age in males

Delay or absence of puberty is caused by

  1. Constitutional delay: a variant of normal
  2. Hypogonadotropic hypogonadism: low gonadotropin levels as a result of a defect of the hypothalamus/pituitary gland
  3. Hypergonadotropic hypogonadism: high gonadotropic levels as a result of a lack of negative feedback because of a gonadal problem. Females may have isolated absence of adrenarche with normal breast development “
105
Q

“2 year old with left flank swelling associated with flushing, sweating

a. Pheochromocytoma
b. Wllms tumor
c. Neuroblastoma
d. None of the above”

A

C

“Phaeochromocytomas and catecholamine secreting neuroblastomas produce similar symptoms, however phaeochromocytomas usually dont present with flank mass

Nelson 21st p2986 Phaeochromocytoma
Phaeochromocytomas detected by surveillance of patients who are known carriers of mutations in tumor-suppression genes may be asymptomatic. Otherwise, patients are detected owing to hypertension, which results from excessive secretion of metanephrines, epinephrine, and norepinephrine. Between attacks of hypertension, the patient may be free of symptoms. During attacks, the patient complains of headache, palpitations, abdominal pain and dizziness; pallor, vomiting, and sweating also occur. Seizures and other manifestations of hypertensive encephalopathy may occur.

Nelson 21st p2680
The signs and symptoms of neuroblastoma reflect the tumor site and extent of disease and may mimic other disorders, which may result in a delayed diagnosis.

Some tumors produce catecholamines that can cause increased sweating and hypertension, and may release vasoactive intestinal peptide, causing a profound secretory diarrhea. Children with extensive tumors can also experience tumor lysis syndrome and disseminated intravascular coagulation.

Nelson 21st p2683
The most common initial clinical presentaiton for Wilms tumor is the incidental discovery of an asymptomatic abdominal mass by parents while bathing or clothing an affected child or by a physician during a routine physical examination. At presentation, the mass can be quite large, because retroperitoneal masses can grow unhampered by strict anatomic boundaries. Functional defects in paired organs, such as the kidney, with good functional reserve, are also unlikely to be detected early. “

106
Q

“Case of leukemia. Diagnostic of choice?

a. BMA
b. Complete blood count
c. PBS
d. Tumor markers”

A

A

“Nelson 21st p2650
ALL is diagnosed by a bone marrow evaluation that demonstrates >25% of the bone marrow cells as a homogenous population of lymphoblasts

Nelson 21st p2654
The characteristic feature of AML is that >20% of bone marrow cells on bone marrow aspiration constitute a fairly homogenous population of blast cells, with features similar to those that characterize early differentiation states of the myeloid-monocyte-megakaryocyte series of blood cells”

107
Q

“6 week old infant with hgb 11 g/dl. Born full term, no complications. At birth Hgb 18 g/dl

a. Physiologic anemia
b. Iron deficiency anemia
c. Anemia of chronic disease
d. None of the above”

A

A

“Nelson 21st p2654
The characteristic feature of AML is that >20% of bone marrow cells on bone marrow aspiration constitute a fairly homogenous population of blast cells, with features similar to those that characterize early differentiation states of the myeloid-monocyte-megakaryocyte series of blood cells’

Nelson 21st p2516-2517 Physiologic anemia of infancy
At birth, normal full-term infants have higher hemoglobin and larger RBCs than do older children and adults. However within the 1st wk of life, a progressive decline in Hgb level begins and persists for 6-8 wk. The resulting anemia is known as physiologic anemia of infancy

Normally this point is reached between 8 and 12 wk of age, when the Hgb concentration is about 11g/dl. In healthy term infants, the nadir rarely falls below 10g/dl

Nelson 21st p2522 IDA
Most children with IDA are asymptomatic and are identified by routine laboratory screening at 9-12 mo of age. Pallor is the most recognized clinical sign of IDA but is not usually visible until the Hgb falls to 7-8g/dl

Nelson 21st p2513 Anemia of chronic disease
ACD is found in conditions where there is ongoing immune activation. It occurs in conditions including infections, malignancies, CKD, autoimmunity, and graft-vs-host disease. ACD is typically a mild to moderate normocytic, normochromic, hypoproliferative anemia associated with decreased serum iron and low transferrin saturation. “

108
Q

“22 weeks AOG fetus. Where does fetal hematopoiesis take place?

a. Yolk sac
b. Bone marrow
c. Liver
d. Placenta”

A

C

“Nelson 21st p2500
In the developing human embryo and fetus, hematopoiesis has 3 developmental waves and is conceptually divided into 3 anatomic stages: mesoblastic, hepatic, and myeloid

  1. Mesoblastic hematopoiesis occurs in extraembryonic structures, principally in the yolk sac, and begins between the 10th and 14th days of gestation. By 10-12wk, extraembryonic hematopoiesis has ceased
  2. By 6-8wk of gestation, the liver replaces the yolk sac as the primary site of blood production, and during this time the placenta also contributes as a hematopoietic site. Hepatic hematopoiesis occurs throughout the remainder of the gestation and then diminishes duing the third trimester. The liver is the predominant hematopoietic organ through 20-24wk of gestation.
  3. Myeloid (bone marrow) hematopoiesis increases during the third trimester until birth and beyond.

Each hematopoietic organ houses distinct populations of cells:

  1. Yolk sac - erythrocytes, megakaryocytes, macrophages
  2. Liver - erythrocytes
  3. Bone marrow - erythrocytes, megakaryocytes, leukocytes”
109
Q

“Case of child with anemia & reticulocytosis. On smear, note spherocytosis and elliptocytosis. The anemia is

a. Hypochromic
b. Normocytic
c. Macrocytic
d. Hemolytic”

A

D

“Nelson 21st p2530 Table 484.4 Hemolytic anemia: Diagnostic clues based on RBC shape

  • Sickle cells - sickle cell disease
  • Target cells - hemoglobinopathies, liver disease
  • Schistocytes/burr cells/helmet cells/RBC fragments - microangiopathic hemolytic anemia (DIC, HUS, TTP)
  • Spherocytes - hereditary spherocytosis, autoimmune hemolytic anemia
  • Cigar shaped cells - hereditary elliptocytosis
  • Bite cells - G6PD deficiency
  • poikilocytosis, microcytosis, fragmented erythrocytes, elliptocytes - hereditary pyropoikilocytosis “
110
Q
"Most sensitive test for IDA
A. Hemoglobin
B. Serum iron stores
C. Serum ferritin
D. TIBC"
A

C

”"”Indicators of iron deficiency anemia
1. Low Hemoglobin - when used alone, has low specificity and sensitivity

  1. Low MCV - reliable but late indicator of iron deficiency; low values can also be a result of thalassemias and other causes of microcytosis. False negative results in liver disease
  2. Low serum ferritin (<12 less than 5 yrs, <15 in greater than 5yrs) - most useful laboratory measure of iron stores. Low ferritin is diagnostic of iron deficiency anemia in a patient with anemia. Ferritin is an acute phase reactant that increases in many acute or chronic inflammatory conditions independent of iron status. In all age groups with infection, ferritin <30-100
  3. Low Reticulocyte hemoglobin content - sensitive indicator that alls within days of onset of iron deficient erythropoiesis and is unaffected by inflammation. Not widely available
  4. High Serum transferrin receptor - upregulated in iron deficiency
  5. Low transferrin - limited by diurnal variation in serum iron and inflammatory conditions, aging, and nutrition
  6. High Erythrocyte zinc protoporphyrin - useful screening test
  7. Low Hepcidin - extremely elevated in anemia of inflammation and suppressed in IDA but limited availability

(Nelson 21st p2523)”””

111
Q
"Bright red lesion on the cheeks with telangiectasia and has grown in size.
A. Hemangioma
B. Portwine stain
C. Sturgg Webber
D. Kasabach Merrit"
A

D

“Nelson 21st p2703
Kasabach-Merritt syndrome is characterized by a rapidly enlarging lesion, thrombocytopenia, microangiopathic hemolytic anemia, and coagulopathy as a result of platelet and RBC trapping and activation of the clotting system within the vasculature of the hemangioma. The syndrome is associated with kaposiform hemangioendotheliomas or tufted angiomas but not with infantile hemangiomas. “

112
Q
"Megaloblastic anemia
A. B12
B. B6
C. B2
D. B1"
A

A

“Nelson 21st p2517
Megaloblastic anemia describes a group of disorders that are caused by impaired DNA synthesis. RBCs are larger than normal at every developmental stage, and there is maturational asynchrony between the nucleus and cytoplasm of erythrocytes.

Most cases of childhood megaloblastic anemia result from a deficiency of folic acid or vitamin B12 (cobalamin), vitamins essential for DNA synthesis”

113
Q

“Reed sternberg cells are seen in:

a) Nonhodgkin’s lymphoma
b) Hodgkin’s lymphoma
c) Burkitt Lymphoma
d) Neuroblastoma”

A

B

“Nelson 21st p2657
The Reed-Sternberg cell, a pathognomonic feature of Hodgkin lymphoma is a large cell (15-45 um in diameter) with multiple or multilobulated nuclei.

This cell type is considered the hallmark of HL, although similar cells are seen in infectious mononucleosis, non-Hodgkin lymphoma, and other conditions

The RS cell is clonal in origin and arises from the germinal center B cells but typically has lost most B-cell gene expression and function. “

114
Q

“Sunburst appearance on x-ray?

a. Ewings sarcoma
b. Osteosarcoma
c. AML
d. Lymphoma”

A

B

“Nelson 21st p2690
Bone tumor should be suspected in a patient who presents with deep bone pain, often causing nighttime awakening, and has a palpable mass with radiographs that demonstrate a lesion. The lesion may be mixed lytic and blastic in appearance, but new bone formation is usually visible. The classic appearance of osteosarcoma is the sunburst pattern.

Nelson 21st p2691
The diagnosis of Ewing sarcoma should be suspected in a patient who presents with pain and swelling, with or without systemic symptoms, and with a radiographic appearance of primarily lytic bone lesion with periosteal reaction, the characteristic onion-skinning. “

115
Q

“What type of concentrate will you transfuse for hemophilia A?

a. Factor 8
b. Factor 9
c. Factor 10
d. Factor 11”

A

A

“Nelson 21st Chapter 503
Hemophilia A - Factor 8 deficiency
Hemophilia B - Factor 9 deficiency
Hemophilia C - Factor 11 deficiency

Nelson 21st p2594
Reduced level of factor 8 and factor 9 will result in a laboratory finding of prolonged PTT

PT measures the activation of factor 10 by factor 7 and is therefore normal in patients with factor 8 or factor 9 deficiency

Nelson 21st p2597
Factor 9 deficiency is an autosomal deficiency associated with mild to moderate bleeding symptoms.

PTT is often longer than it is with patients with severe factor 8 or facotr 9 deficiency. The paradox of fewer clinical symptoms with longer PTT occurs because factor 7a can activate factor 11 in vivo”

116
Q

“Child with purpura but with normal WBC and RBC count. Decreased platelet.

a. ITP
b. HSP
c. Leukemia
d. Meningococcemia”

A

A

"Nelson 21st p2612 ITP
Sever thrombocytopenia (PC <20 x 10^9/L) is common, and platelet size is normal or increased, reflective of increased platelet turnover. In acute ITP the hemoglobin value, WBC count, and differential count should be normal. 

Nelson 21st p1320 HSP
No laboratory finding is diagnostic of HSP. Common but nonspecific findings include leukocytosis, thrombocytosis, mild anemia, and elevations of ESR and CRP. The platelet count is normal in HSP

Nelson 21st p1472 Meningococcemia
Laboratory findings are variable but may include leukocytopenia or leukocytosis, often with increased percentage of neutrophils and band forms and anemia, thromocytopenia, proteinuria, and hematuria.

Nelson 21st p2650
The diagnosis of ALL is strongly suggested by peripheral blood findings that indicate bone marrow failure. Anemia and thrombocytopenia are seen in most patients. “

117
Q

“What blood count do you expect in a child with a giant Hemangioma?

a. Decreased WBC
b. Decreased RBC
c. Low platelet count
d. Erythrocytosis”

A

C

“Thrombocytopenia may be seen with sequestration of platelets within the hemangioma, as seen in the pathophysiology of Kasabach-Meritt syndrome

Nelson 21st p2703
Kasabach-Merritt syndrome is characterized by a rapidly enlarging lesion, thrombocytopenia, microangiopathic hemolytic anemia, and coagulopathy as a result of platelet and RBC trapping and activation of the clotting system within the vasculature of the hemangioma. The syndrome is associated with kaposiform hemangioendotheliomas or tufted angiomas but not with infantile hemangiomas. “

118
Q
"Patient with oliguria/ acute renal failure was transfused with pRBC. He is at risk for?
A. Hypercalcemia
B. Hypocalcemia
C. Hypernatremia
D. Hyperkalemia"
A

D

119
Q
"Patient post-blood transfusion developed seizure.
A. Hypocalcemia 
B. Hyponatremia
C. Hyperkalemia
D. Hypercalcemia"
A

A

120
Q
"CBC of patient revealed mild microcytic anemia. Finding in ThalassemIa trait.
A. Low MCV
B. Iron deficiency
C. Increased RDW
D. None of the above"
A

A

“Nelson 21st p2555
Infants with serious B-thalassemia disorders have a progressive anemia after the newborn period. Microcytosis, hypochromia, and targeting characterize the RBCs. Nucleated RBCs, marked anisopoikilocytosis, and a relative reticulocytopenia are typically seen. The Hgb level falls progressively often to <6 g/dL unless transfusions are given. The reticulocyte count is commonly <8% and is inappropriately low compared to the degree of anemia caused by ineffective erythropoiesis.

121
Q

“Who will benefit from FFP transfusion?
A. Chronic liver disease without bleeding with prolonged PT and PTT
B. Von Willebrand disease for liver biopsy
C. Neonate with purpura fulminans, family history of warfarin induced skin necrosis
D. All of the above”

A

D

“Nelson 21st p2586 Table 500.1 Guidelines for children and infants for plasma transfusions

  1. Severe clotting factor deficiency AND bleeding
  2. Severe clotting factor deficiency AND an invasive procedure
  3. Emergency reversal of warfarin effects
  4. Dilutional coagulopathy and bleeding (e.g. massive transfusion)
  5. Anticoagulant protein (antithrombin III, proteins C and S) replacement
  6. Plasma exchange replacement fluid for thrombotic thrombocytopoenic purpura or for disorders with overt bleeding or in which there is a risk of bleeding because of clotting protein abnormalities”
122
Q
"At risk for relapse and poor prognosis in acute leukemia.
A. Age <10 yo
B. WBC count 40,000
C. Blasts in BM >25%
D. Chromosome  t(9:22)"
A

D

“Lanzkowsky 6th ed p376 Table 18.6 prognostic factors in childhood acute lymphoblastic leukemia

Favorable

  • age 1-9 years
  • WBC count <50 x 10^9/l
  • B-precursor cell immunophenotype
  • female sex
  • Trisomy 4, 10, 17
  • t(12;21) / ETV6-RUNX1
  • no CNS involvement
  • end of induction D29 minimal residual disease <0.01%

Less favborable

  • age <1 or >10
  • WBC count >50 x 10^9/l
  • T-cell immunophenotype
  • male sex
  • MLL rearrangement
  • t(9;22) / BCR-ABL1 iAMP21 (Philadelphia Chromosome)
  • with CNS involvement
  • end of induction D29 minimal residual disease >0.01%
  • positive minimal residual disease at end consolidation”
123
Q
"Vaccines that may not be given to a child who is currently undergoing chemotherapy EXCEPT
A. BCG
B. MMR and Varicella
C. Flu
D. Measles"
A

C

Live attenuated vaccines are contraindicated in patients recieving chemotherapy

124
Q
"Which test will differentiate hemophilia from vitamin K deficiency?
A. Bleeding time
B. PT
C. PTT
D. Platelet count"
A

B

“Nelson 21st p2594 Hemophilia
Reduced level of factor 8 and factor 9 will result in a laboratory finding of prolonged PTT

PT measures the activation of factor 10 by factor 7 and is therefore normal in patients with factor 8 or factor 9 deficiency

Nelson 21st p972 VKDB
Laboratory testing reveals that both the PT and PPT are prolonged, plasma levels of prothrombin (factor 2), and factors 7, 9, and 10 are substantially decreased

The pathophysiology of this acquired hemorrhagic disorder results because vitamin K facilitates posttranscriptional carboxylation of factors 9, 10, 7, and 2, which is necessary for their full coagulation effects. “

125
Q

“Mother brought her 6 year old daughter to you because of epistaxis. Noted in the family history mother experiences menorrhagia . What is your diagnosis?

a. Wiscott Aldrich Syndrome
b. Hemophilia
c. Von Willebrand Disease
d. Fanconi disease”

A

C

“Nelson 21st p2599
Von Willebrand disease is the most common inherited bleeding disorder. VWD is caused by a defect in or deficiency of von Willebrand factor.

VWF serves to tether platelets to injured subendothelium via binding sites for platelets and collagen, and is also a carrier protein for factor 8, protecting factor 8 from degradation in plasma.

VWD typically presents with mucosal bleeding, similar to that seen with other platelet defects. Epistaxis, easy bruising, and menorrhagia in women are common complaints. “

126
Q

“Apreviously well,4.year old male had sudden onset of generalized petechiae & purpura. He had anURTI last week. His CBC showed normal Hgb , Hct, WBC & differential counts with platelet count 15. The peripheral blood smear showed large platelets while the BMA showed increased number of megakaryocytes with some appearing immature. What is the most likely diagnosis?
A. Wiskott-Aldrich syndrome
B. Hemangioma
C. Idiopathic immune thrombocytopenic purpura
D. Hereditary macrothrombocytopenia”

A

C

“Nelsons 21st p2612
The most common cause of acute onset of thrombocytopenia in an otherwise well child is idiopathic thrombocytopenic purpura (ITP)

The classic presentation of ITP is a previously healthy 1-4yr old child who has sudden onset generalized petechiae and purpura. There is a history of preceding viral infection 1-4 wk before the onset of thrombocytopenia. Findings on PE are normal, other than petechiae and purpura.

Severe thrombocytopenia (PC <20 x 10^9/L) is common, and platelet size is normal or increased, reflective of increased platelet turnover. In acute ITP, Hgb, WBC and differential count should be normal.

Bone marrow examination shows normal granulocytic and erythrocytic series, with characteristically normal or increased numbers of megakaryocytes. Some of the megakaryocytes may appear immature and reflect increased platelet turnover.

Indications for bone marrow biopsy include an abnormal WBC count or differential or unexplained anemia, as well as history and PE findings suggestive of a bone marrow failure syndrome or malignancy.

127
Q
"Which of the following tests can differentiate iron deficiency anemia from anemia of chronic disease?
A. Hemoglobin
B. Red cell distribution width
C. Serum ferritin
D. Transferrin saturation"
A

C


Nelson 21st p2524 Table 482/2 Laboratory studies differentiating the most common microcytic anemias

IDA 
Decreased Hgb
Decreased MCV
Increased RDW
Decreased RBC
Decreased serum ferritin
Increased total Fe binding capacity 
Decreased transferrin saturation
Increased FEP
Increased soluble transferrin receptor
Decreased reticulocyte Hgb concentration
ACD
Decreased Hgb
Normal-Decreased MCV
Normal-Increased RDW
Normal-Decreased RBC
Increased serum ferritin
Decreased total Fe binding capacity 
Decreased transferrin saturation
Increased FEP
Normal soluble transferrin receptor
Normal-Decreased reticulocyte Hgb concentration
Thalassemia
Decreased Hgb
Decreased MCV
Normal or minimally increased RDW
Normal-increased RBC
Normal serum ferritin
Normal total Fe binding capccity 
Normal transferrin saturation
Normal FEP
Normal soluble transferrin receptor
Normal reticulocyte Hgb concentration"
128
Q
"A 2-year old girl became jaundiced & had coke-colored urine after ingesting a naphthalene ball. His hemoglobin was 6 g / dl with a reticulocyte count of 15. He had hemoglobinuria. What disease must be considered?
A. Pyruvate kinase deficiency
B. Auto-immune hemolytic anemia
C. G-6-PDdeficiency
D. Phosphorylase deficiency"
A

C

“Nelson 21st p2561 G6PD deficiency
Typically, hemolysis ensues in about 24-48hr after a patient has ingested a substance with oxidant properties. In severe cases, hemoglobinuria and jaundice result, the the Hgb concentration may fall precipitously.

The onset of acute hemolysis usually results in a precipitous fall in hemoglobin or hematocrit. If the episode is severe, the Hgb binding globulins such as haptoglobin are saturated, and free hemoglobin may appear in the plasma and subsequently in the urine.

Unstained or supravital preparations of RBCs reveal precipitated hemoglobin, or Heinz bodies. Also, the blood film may contain red cells with what appears to be a bite taken from their periphery (bite cells) and polychromasia (blueish larger RBCs) representing reticulocytosis. “

129
Q

“Varicella vaccine is recommended to be given

a. 2 to 4 weeks
b. 12 months
c. 14 weeks
d. None of the above”

A

B

“Prev Ped 2018 p70-71

Varicella Vaccine

  • given subcutaneously
  • given at a minimum age of 12 months
  • 2 doses of varicella vaccine are recommended
  • the 2nd dose is usually given at 4-6 years of age, but may be given earlier at an interval of 3 months from the 1st dose
  • if the 2nd dose was given 4 weeks from the 1st dose, it is considered valid
  • for children 13 years old and above, the recommeneded minimum interval between doses is 4 weeks”
130
Q

Patient with vesicles on trunk. Noted outbreak in school. Diagnosis?

A

Varicella

“Nelson 21st p1709
Within households, transmission of VZV to susceptible individuals occurs at a rate of 65-86%; more casual contact, such as occurs in a school classroom, is associated with lower attack rates among susceptible children. “

131
Q

“When is neonatal varicella acquired?

a. 5 days before and 2 days after birth
b. 2 days before and 5 days after birth
c. 7 days before and 7 days after birth
d. 5 days before and 7 days after birth”

A

A

”"”Persons with varicella may be contagious 24-48 hours before rash is evident and until vesicles are crusted, usually 3-7 days after onset of rash.

Varicella is spread by aerosolization of virus in cutaneous lesions and by oropharyngeal secretions (Nelson 21st p1709)

Mortality is particularly high in neonates born to susceptible mothers who contract varicella around the time of delivery. Infants whose mothers demonstrate varicella in the period from 5 days prior to delivery to 2 days afterwards are at high risk for severe varicella. (Nelson 21st p1710)”””

132
Q

“When does the rash of measles fade?

a. 3 days
b. 5 days
c. 7 days
d. 9 days”

A

C

“Nelson 21st p1671-1672
Measles is a serious infection characterized by high fever, an enanthem, cough, coryza, conjunctivitis, and a prominent exanthem.

After an incubation period of 8-12 days, the prodromal phase begins with a mild fever followed by onset of conjunctivitis with photophobia, coryza, a prominent cough, and increasing fever.

Koplik spots represent the enanthem and are the pathognomonic sign of measles, appearing 1-4 days prior to the onset of the rash. They first appear as discrete red lesions with bluish white spots on the center on the inner aspects of the cheeks at the level of the premolars.

Symptoms increase in intensity for 2-4 days until the 1st day of the rash. The rash begins on the forehead, behind the ears, and on the upper neck as a red maculopapular eruption. It then spreads downwards to the torso and extremities, reaching the palms and soles in 50% of cases. The exanthem frequently becomes confluent on the face and upper trunk.

With the onset of the rash, symptoms begin to subside. The rash fades over about 7 days in the same progression as it eveolved, often leaving a fine desquamation of skin in its wake. Of the major symptoms, the cough last the longest, often up to 10 days. “

133
Q

“Most common cause of pleural effusion in children

a. TB
b. Malignancy
c. Pneumonia
d. Hemothorax”

A

C

“Nelson 21st p2274
The most common cause of pleural effusion in children is bacterial pneumonia. Heart failure, rheumatologic causes, and metastatic intrathoracic malignancy are also common causes.”

134
Q

“Treatment for ascariasis

a. Albendazole 400 mg for 3 days
b. Mebendazole 100 mg for 5 days
c. Mebendazole 500 mg as single dose
d. Albendazole 500mg as single dose”

A

C

“Nelson 21st p1878
Treatment for gastrointestinal ascariasis
1. Albendazole 400mg PO SD for all ages
2. Mebendazole 100mg PO BID x 3 days OR 500mg PO SD for all ages)
3. Ivermectin (150-200 ug/kg PO SD)

Intestinal or biliary obstruction
1. Piperazine citrate (75mg/kg/day x 2 days), causes neuromuscular paralysis and rapid expulsion of worms “

135
Q

“Helminth acquired from larval skin penetration?

a. Ascaris lumbricoides
b. Trichinella spiralis
c. Strongyloides stercoralis
d. Enterobius vermicularis”

A

C

“Nelson 21st p1877 Ascaris
Transmission is primarily hand to mouth but also may involve ingestion of contaminated raw fruits and vegetables. Transmission is enhanced by the high output of eggs and the resistance of ove to the outside environment

Nelson 21st p1889 Trichinella
Human trichinellosis is caused by consumption of mean containing encysted larvae of Trichinella spiralis, a tissue-dwelling nematode with a worldwide distribution

Nelson 21st p1883 Strongyloides
Humans are usually infected through skin contact with soil contaminated with infectious larvae. Larvae penetrate the skin, enter the venous circulation and then pass into the lungs, break into alveolar spaces, and migrate up the bronchial tree. They are then swallowed and pass through the stomach, and adult worms develop in the small intestine.

Nelson 21st p1882 Enterobius
Human infection occurs by the fecal-oral route typically by ingestion of embryonated eggs that are carried on fingernails, clothing, bedding, or house dust. “

136
Q

“Helminth causing intestinal obstruction

a. Ascaris lumbricoides
b. Strongyloides stercoralis
c. Enterobius vermicularis
d. Brugia malayi”

A

A

“Nelson 21st p1877 Ascariasis
The most common clinical problems are from pulmonary disease and obstruction of the intestinal or biliary tract.

The pulmonary manifestation resemble Loeffler syndrome and include transient respiratory symptoms such as cough and dyspnea, pulmonary infiltrates, and blood eosinophilia.

A more serious complication occurs when a large mass of worms leads to acute bowel obstruction. Ascaris worms also occasionally migrate into the biliary and pancreatic ducts, where they cause cholecystitis or pancreatitis. “

137
Q

“Treatment for extraluminal amebiasis

a. Metronidazole
b. Diloxanide furoate
c. Paromomycin
d. Iodoquinol”

A

A

“Nelson 21st p1832
Invasive amebiasis is treated with nitroimidazoles such as metronidazole or tinidazole and then a luminal amebecide.

Therapy with a nitroimidazole should be followed by a luminal agent such as paramomycin or iodoquinol. Diloxannide furoate can also be used in children >2yr of age but it is no longer available in the United States. “

138
Q

“Patient presents with fever, pharyngitis, non-suppurative conjunctivitis

a. Adenovirus
b. Kawasaki disease
c. Scarlet fever
d. All of the above”

A

A

“Nelson 21st p1740
Pharyngoconjunctival fever is a distinct syndrome that includes a high temperature, pharyngitis, nonpurulent conjunctivitis, and preauricular and cervical lymphadenopathy

Kawasaki also presents with fever and nonsuppurative conjunctivitis”

139
Q

“A 2 year old patient who obtained a wound. She received 2 doses of DTAP 2 years ago, what would you give?

a. Td
b. Tetanus toxoid
c. TIG
d. DTAP”

A

D

“Nelson 21st p1552 Table 238.1 Tetanus vaccination and immune globulin use in wound management

Uncertain or <3 doses tetanus toxoid

  1. Clean minor wounds - give DTaP, Tdap, or Td, do not give TIG
  2. All other wounds - give DTaP, Tdap or Td, give TIG

> =3 doses tetanus toxoid

  1. Clean minor wounds
    - do not give DTaP, Tdap, or Td if <10 yr since last dose of tetanus containing vaccine
    - give DTaP, Tdap or Td if >=10 yr since last dose of tetanus containing vaccine
    - do not give TIG
  2. All other wounds
    - do not give DTaP, Tdap or Td if <5 yr since last dose of tetanus containing vaccine
    - give DTaP, Tdap or Td if >=5 yr since last dose of tetanus containing vaccine
    - do not give TIG”
140
Q

“A kid was bitten by a healthy domesticated dog. What will you recommend?

a. Give rabies vaccine and RIG
b. Observe dog for 10 days
c. Kill the dog and look for negri bodies
d. None of the above”

A

B

141
Q

“HIV positive mother, what test and when to do it in the baby?

a. PCR DNA at birth
b. PCR DNA at 6 weeks
c. ELISA at birth
d. Western blot at 3 months”

A

A

“Nelson 21st p1787
All infants born to HIV-infected mothers test antibody-positive at birth because of passive trasnffer of maternal HIV antibody across the placenta during gestation; therefore, antibody should not be used to establish the diagnosis of HIV in an infant.

Viral diagnostic testing should be performed within the first 12-24 hr of life, particularly for high-risk infants. “

142
Q
"A 5 yo male came In with cough of 5 days, low grade fever. He sought closure due to persistence. Rr 28 other vitals normal.
What is your management?
A. Supportive and symptomatic management
B. Amoxicillin 50mkd
C. Nebulization wit h B-agonist
D. Cant remember"
A

A

“Nelson 21st p2185
The most common pathogens associated with the common cold are the more than 200 types of human rhinoviruses. Many viruses that cause rhinitis are also assocaited with other symptoms and signs such as cough, wheezing, and fever. “

143
Q

“6yo female with conjuctivitis, cough, coryza and rashes. How long is the patient infectious?
A. 4 days before to 4-6 days after the rash
B. 6 days before to 5 days after the rash
C. 5 days before and 2 days after the rash
D. 7 days before and 7 days after the rash”

A

A

”"”Nelson 21st p1671-1672
Measles is a serious infection characterized by high fever, an enanthem, cough, coryza, conjunctivitis, and a prominent exanthem.

After an incubation period of 8-12 days, the prodromal phase begins with a mild fever followed by onset of conjunctivitis with photophobia, coryza, a prominent cough, and increasing fever.

Koplik spots represent the enanthem and are the pathognomonic sign of measles, appearing 1-4 days prior to the onset of the rash. They first appear as discrete red lesions with bluish white spots on the center on the inner aspects of the cheeks at the level of the premolars.

Symptoms increase in intensity for 2-4 days until the 1st day of the rash. The rash begins on the forehead, behind the ears, and on the upper neck as a red maculopapular eruption. It then spreads downwards to the torso and extremities, reaching the palms and soles in 50% of cases. The exanthem frequently becomes confluent on the face and upper trunk.

With the onset of the rash, symptoms begin to subside. The rash fades over about 7 days in the same progression as it eveolved, often leaving a fine desquamation of skin in its wake. Of the major symptoms, the cough last the longest, often up to 10 days. “””

144
Q
"Mother has Hepa A. Baby is 15 months old, immunocompetent. How would you give the prophylaxis?
A. Hepatitis vaccine immediately
B. Hepa IG 5-7 days after exposure
C. Hepa vaccine 5-7 days after exposure
D. lmmunoglobulin immediately afte"
A

A

“Nelson 21st p2109
Indications for intramuscular administration of Ig include preexposure and postexposure prophylaxis.

Ig is recommended for preexposure prophylaxis for susceptible travelers to countries where HAV is epidemic.

HAV vaccine given any time before travel is preferred for preexposure prophylaxis in healthy persons by Ig ensures an appropriate prophylaxis in children younger than 12mo old, patients allergic to a vaccine component, or those who elect not to recieve the vaccine. If travel is planned in <2wk, older patients, immunocopromised hosts, and those with chronic liver disease or other medical conditions should recieve both Ig and HAV vaccine.

Ig prophylaxis in postexposure situations should be used as soon as possible (it is not effective if administered more than 2wk after exposure). It is exclusively used for children younger than 12mo old, immunocompromised hosts, those with chronic liver disease or in whom vaccine is contraindicated. Ig is preferred in patients older than 40yr of age, with HAV vaccine preferred in healthy persons 12mo to 40yr old.”

145
Q
"What is the first serologic marker to be detected in Hepa B infection?
A. HbV surface antigen
B. Anti- HbsAgl gM
C. Anti-HbcAg lgM
D. Anti -HbeAg lgG"
A

A

“Nelsons 21st p2112
HbsAg is an early serologic marker of infection and is found in almost all infected persons; its rise closely coincides with the onset of symptoms. Persistence of HBsAg beyond 6mo defines the chronic infection state.

During recovery from acute infection, because HbsAg levels falls before symptoms wane, anti-HBc IgM might be the only marker of acute infection.

Anti-HBc IgM rises early after the infection and remains positive for many months before being replaced by anti-HBc IgG, which then persists for years.

Anti-Hbs marks serologic recovery and protection. Only Anti-HBs is present in persons immunized with hepatitis B vaccine, whereas both anti-HBs and anti-HBc are detected in persons with resolved infection.

HBeAg is present in active acute or chronic infection and is a marker of infectivity. The development of anti-HBe, termed seroconversion, marks improvement and is a goal of threapy in chronically infected patients.

HBV DNA can be detected in the serum of acutely infected patients and chronic carriers. High DNA titers are seen in patients with HBeAg, then typically fall once anti-HBe develops. “

146
Q
"Patient was diagnosed with Hepa B 2 months ago. What serologic marker is the best to detect infection.
A. Anti-Hbc lgM
B. HbsAg
C. Ant i-Hbe lgG
D. Anti-Hbs lgM"
A

B

”"”Nelsons 21st p2112
HbsAg is an early serologic marker of infection and is found in almost all infected persons; its rise closely coincides with the onset of symptoms. Persistence of HBsAg beyond 6mo defines the chronic infection state.

During recovery from acute infection, because HbsAg levels falls before symptoms wane, anti-HBc IgM might be the only marker of acute infection.

Anti-HBc IgM rises early after the infection and remains positive for many months before being replaced by anti-HBc IgG, which then persists for years.

Anti-Hbs marks serologic recovery and protection. Only Anti-HBs is present in persons immunized with hepatitis B vaccine, whereas both anti-HBs and anti-HBc are detected in persons with resolved infection.

HBeAg is present in active acute or chronic infection and is a marker of infectivity. The development of anti-HBe, termed seroconversion, marks improvement and is a goal of threapy in chronically infected patients.

HBV DNA can be detected in the serum of acutely infected patients and chronic carriers. High DNA titers are seen in patients with HBeAg, then typically fall once anti-HBe develops. “””

147
Q
"5 yo male, cough, 5 days. Symptoms persisted with fever, more productive cough. Rr 32, crackles, cxr diffuse infiltrates, wbc 20000 neut 30 ly 70. Management?
A. Symptomatic and supportive
B. Nebulization with b- agonist
C. Amoxicillin 50mkd
D. Clarithromycin 15mkd"
A

D

“Likely atypical pneumonia based on prevalence for age, CBC findings.

Nelson 21st p2268 Table 428.3 Pneumonia etiologies grouped by age of the patient

For >=5 yr, frequent pathogens include M. pnuemoniae, S. pneuoniae, C. pneumophila, Hib, influenza virus, adenovirus, other respiratory viruses, Legionella

Nelson 21st p2271
In viral pnuemonia, the WBC count can be normal or elevated but is usually not higher than 20,000 mm3 with a lymphocyte predominance. Bacterial pneumonia is often associated with an elevated WBC count in the range of 15,000-40,000/mm3 and a predominance of polymorphonuclear leukocytes.

Atypical pnuemonia caused by C. pneumoniae or M. pneumoniae is difficult to distinguish from pneumococcal pneumonia on the basis of radiographic and laboratory findings.

For school-aged children and adolescents or when infection with M. pneumoniae or C. pneumoniae is syspected, a macrolide antibiotic is an appropraite choice for outpatient management. “

148
Q
"Most common site of TB enteritis
A. Jejunum
B. Descending colon
C. Rectum
D. ileocecal"
A

A

“Nelson 21st p1575
Tuberculous enteritis is caused by hematogenous dissemination or by swallowing tubercle bacilli discharged from the patient’s own lungs. The jejunum and ileum near Peyer patches and the appendix are the most common sites of involvement.”

149
Q
"Patient had sudden bilateral ascending paralysis with dysphagia after viral infection.  What vaccine should not be given?
A. Influenza
B. MMR
C. Varicella
D. None of the above"
A

A

“Nelson 21st p3335
GBS may follow administration of vaccines against rabies, influenza, and conjungated meningococcal vaccine. “

150
Q
"Case of a 5 yo male. 10 days cough, persistent. Given ampicillin 7 days. No effect. RR 40s, crackles, retractions, occasional wheezes. Management ?
A. Supportive
B. Nebulization with b-agonist
C. Cefuroxime 50mkd
D. Clarithromycin 15mkd"
A

C

“Likely atypical pneumonia based on prevalence for age, CBC findings, nonresponse to ampicillin

Nelson 21st p2268 Table 428.3 Pneumonia etiologies grouped by age of the patient

For >=5 yr, frequent pathogens include M. pnuemoniae, S. pneuoniae, C. pneumophila, Hib, influenza virus, adenovirus, other respiratory viruses, Legionella

Nelson 21st p2271
In viral pnuemonia, the WBC count can be normal or elevated but is usually not higher than 20,000 mm3 with a lymphocyte predominance. Bacterial pneumonia is often associated with an elevated WBC count in the range of 15,000-40,000/mm3 and a predominance of polymorphonuclear leukocytes.

Atypical pnuemonia caused by C. pneumoniae or M. pneumoniae is difficult to distinguish from pneumococcal pneumonia on the basis of radiographic and laboratory findings.

For school-aged children and adolescents or when infection with M. pneumoniae or C. pneumoniae is syspected, a macrolide antibiotic is an appropraite choice for outpatient management. “