Receptors And Drug Affects On Postsynaptic Tissue

Question 1

DA

Answer 1

D2 family (D2, D3, D4) metabotropid transduction

D1 family (D1 & D5)

Question 2

Adrenergic (NE, EPI)

Answer 2

a1-a2 
Alpha 1a 
Alpha1b ……until 1d
Beta 1 -3
Metabptropib both

Question 3

Opiate:

Answer 3

m, d, k

Question 4

GABA:

Answer 4

Gaba A and Gaba B

Question 5

Agonist

Answer 5

drug binds to receptor, stimulates same intrinsic activity as neurotransmitter

Question 6

Full agonist

Answer 6

drug binds to receptor, stimulates very high levels of intrinsic activity

Question 7

PARTIAL AGONIST

Answer 7

PARTIAL AGONIST: binds to receptor, weakly stimulates intrinsic activity, blocks activity produced by drugs or neurotransmitter with higher intrinsic activity
Can act as an antagonist if the Nt is high

Question 8

Competitive antagonist

Answer 8

binds to receptor, has no intrinsic activity, blocks activity produced by neurotransmitter

Question 9

5-HT receptots

Answer 9

5-HT1A, 1B, 1C, 1D, 1E (Gi) 
5-HT 2A, 2B, 2C (Gq) 
5-HT 3 (ionotropic) 
5-HT 4 (Gs) 5-HT 5A, 5B (Gi)
 5-HT 6 (Gs) 
5-HT 7 (Gs)
Autoreceptors: 5-HT 1A,1B and 1D

Question 10

Choline has its own transporter

Answer 10

It is also a metabolite as well as precursor

Question 11

ACh

Answer 11

Nicotinic ionotropic and linked to a cation channel

Muscarunic metabotropic
M1 (Gq) , M2 (Gi), M3 (Gq), M4 (Gi), M5 (Gq)