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PLABABLE 2.0 > Rheumatology > Flashcards

Rheumatology Flashcards

1
Q

Specific autoantibody for:

SLE

A

Anti-dsDNA

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2
Q

Sensitive autoantibody for SLE

A

ANA (anti-nuclear antibody)

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3
Q

Autoantibody for diffuse scleroderma vs. limited scleroderma (CREST)

A

Anti-scl70

Anti-centromere

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4
Q

Autoantibody for polymyositis and Sjogren’s syndrome

A

Polymyositis - anti-Jo1

Sjogren’s sndrome - anti-Ro, anti-La

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5
Q

Autoantibody for primary biliary cirrhosis, autoimmune hepatitis

A

PBC - anti-mitochondrial

Autoimmune hepatitis - anti-smooth muscle

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6
Q

Autoantibodies for Churg-Strauss vs Wegener’s granulomatosis

A

Wegener’s granulomatosis - c-ANCA

Churg-Strauss - p-ANCA

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7
Q

Most specific autoantibody for rheumatoid arthritis

A

Anti-CCP

***IN fact, it is more sensitive and specific for RA compared to RF. (RA Revision Guide)

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8
Q

Autoantibodies for coeliac disease

A

Anti-tissue transglutaminase
Anti-gliadin
Anti-endomysial

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9
Q

Autoantibody for Graves disease

A

TSH-receptor antibody

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10
Q

Drugs causing lupus

A

INH - (INH causes SLE)
Chlorpromazine
Hydralazine

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11
Q

SLE and antinuclear antibody. Clinchers

A

Initial tests
Most sensitive test
Best screening test

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12
Q

SLE and antidsDNA

A

Most specific test

Most discriminative

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13
Q

Definitive test for polymyositis

Autoantibody for polymyositis

A

Muscle biopsy

Anti-Jo1

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14
Q

Treatment for polymyositis

A

Steroids

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15
Q

Treatment for dermatomyositis

A

Steroids

Sun-blocking agent

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16
Q

Differentiate polymyositis from dermatomyositis

A

In polymyositis, you will be given a stem of a patient having difficulty standing from the chair or combing hair while in dermatomyositis, you have a patient with dermatologic manifestations in addition to weakness. They are both managed with steroids, however, in dermatomyositis, you also given sunblocking agent.

17
Q

Features and associated condition of polymyalgia rheumatica

A 
Bilateral pain (neck, shoulder or pelvic girdle) and morning stiffness
Difficulty standing from bed or raising arm to comb hair

Associated with giant cell arteritis

Aged (>50y/o)

18
Q

Best initial test for giant cell arteritis

A

Elevated ESR

19
Q

Definitive test for giant cell arteritis

A

Tamporal artery biopsy

20
Q

Why would you not wait for biopsy if you suspect giant cell arteritis?

A

Give HIGH—DOSE prednisolone as delaying can result in permanent loss of vision

21
Q

In addition, to high-dose prednisolone, what other medication should be given in a patient with giant cell arteritis?

A

Low-dose aspirin

22
Q

GEMS of Behcet’s Disease

A

Genital ulcer
(Eye) Uveitis
(Mouth) Oral ulcer
Skin injury exaggerated after minor trauma

23
Q

Treatment of Behcet’s disease

A

Topical corticosteroids

24
Q

Seronegative spondyloarthropathies - associated with HLA-B27

A

PAIR-B

Psoriatic arthritis
Ankylosing spondylitis
IBD-associated arthritis
Reiter’s syndrome
Behcet’s disease
25
Q

Features of ankylosing spondylitis

A

Morning stiffness, improves with physical activity

Also associated with anterior uveitis (or iritis, or iridocyclitis)

26
Q

Ankylosing spondylitis : uveitis :: Reiter’s syndrome: ________

A

Conjunctivitis

27
Q

Most commonly involved joint in gout

A

1st metatarsal phalangeal joint

28
Q

What is HEALS of Lofgren?

A 
Hilar
Erythema nodosum
Arthritis
Lofgren
Sarcoidosis
29
Q

Difference between Mikulicz’s disease and Mikulicz’s syndrome

A

Mikulicz’s disease - no specific cause

Mikulicz’s syndrome - symptoms are secondary to sarcoidosis or TB

30
Q

Four steps in managing rheumatoid arthritis

A

Refer to rheuma
Steroids - to reduce inflammation
NSAIDs - to relieve pain
DMARDs (MTX) - first line

31
Q

What are the associated eye condition with ankylosing spondylitis?

A

Uveitis, Iritis, Iridocyclitis

32
Q

What are the associated eye condition with rheumatoid arthritis?

A

Scleritis

Episcleritis

33
Q

JONES criteria’s Major manifestations in the diagnosis of Rheumatic Fever

A 
Joints (arthritis)
O-heart (carditis)
Nodules (SC nodules)
Erythema marginatum
Sydenham chorea
34
Q

Sensitive and specific lab tests in the diagnosis of Rheumatic Fever

A

Sensitive - ESR

Specific - ASO

PLABABLE 2.0 (33 decks)

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