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Pharmo Test Two Old Test Review > 2020 Old Exam > Flashcards

2020 Old Exam Flashcards

1
Q

Epi released from the adrenal medulla is considered a

A

hormone

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2
Q

If a pt is taking albuterol (a beta-agonist), do not give

A

a beta blocker

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3
Q

What fires at once “all or nothing”

A

Sympathetic

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4
Q

Sympathetic is…

A

Short preganglionic fibers, long postganglionic fibers

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5
Q

Preganglionic fibers release

A

ach

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6
Q

What breaks down Ach

A

cholinesterase

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7
Q

adrenergic fibers release what

A

Norepinephrine

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8
Q

When developing a dry mouth drug, what do you target

A

M3 Muscarinic 3

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9
Q

Which of the following is an irreversible indirect acting cholinergic

pick the one that isn’t reversible (‘-stigmine’ agents, donepezil,
galantamine)

A

parathion

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10
Q

Cevimeline

A

Increases salivation and lacrimation

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11
Q

What regenerates AChE

A

pralidoxime

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12
Q

What does atropine not do

A

Bronchoconstriction (b/c it does bronchodilation)

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13
Q

What does atropine not treat

A

paralysis

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14
Q

What is a quaternary amine that is used to dry secretions

A

glycopyrrolate

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15
Q

What is a depolarizing neuromuscular blocker

A

succinylcholine

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16
Q

Which of the following neuromuscular blockers will result in an increase in serum potassium

A

succinylcholine

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17
Q

What mediates actin-myosin binding?

A

calcium

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18
Q

Which of the following drugs results in dry mouth and sedation and binds to a histamine receptor

A

Diphenhydramine (Benadryl)

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19
Q

T/F: variation is defined as diff drug concentrations at sites of drug action or by different responses to the same drug concentration

A

True

20
Q

(had a description of the pt taking amitriptyline and its ability to block alpha-1
receptors). What type of variation is this

A

pharmacodynamic

21
Q

Chinese do not metabolize alcohol well and get an increase in what in their plasma

A

acetaldehyde

22
Q

Older pts have what phase of metabolism impaired resulting in drug accumulation

A

phase 1

23
Q

Pregnant pt takes lithium which is excreted through the kidney. How her pregnancy
affect the drug concentration of lithium?

A

decrease lithium level

24
Q

Pregnant pt have ____ RBF and ____ GFR

A

increase , increase

25
Q

Pt is taking a drug with codeine. what effect occurs due to the pt’s drugs

A

slowed absorption

26
Q

What anti-epileptic medication results in gingival hyperplasia and affects CYP450 3A4

A

Phenytoin (be careful b/c all 3 anti-epileptic medications were listed)

27
Q

Which of the following adverse effects is independent of the main pharmacological
action?

A

Clozapine and seizures

28
Q

What is an example of a non-covalent interaction of toxin-induced cell damage?

A

hydrogen peroxide

29
Q

What results from the covalent modification of DNA

A

mutagenesis

30
Q

What results in anaphylactic shock

A

penicillin

31
Q

Which of the following drugs results in less platelet count

A

valproic acid/ divalprox

32
Q

At what phase do Na+ channels open

A

phase 0

33
Q

On a ECG, which of the following is atrial depolarization

A

p wave

34
Q

Which of the following cardiac arrhythmias is <60bpm

A

bradycardia

35
Q

Which of the following drugs has an altered taste

A

propafenone class Ic

36
Q

Which of the following classes serves as a beta-blocker

A

class II

37
Q

Which of the following classes serves as a potassium channel blocker

A

class III

38
Q

Which of the following drugs results in QT prolongation and increased risk for TdP

A

Dofetilide a class III

39
Q

Which of the following drugs is a “slow” L-type calcium channel blocker

A

ditiazem a class IV

40
Q

Which of the following drugs will result in gingival hyperplasia

A

Amlodipine a class IV dihydropyridine (b/c ends in ‘-dipine’)

41
Q

Cardiac output is a function of stroke volume and

A

heart rate

42
Q

Which of the following is a phosphodiesterase-3 enzyme inhibitor

A

milrinone

43
Q

Which of the following drugs increases O2 supply but does not change O2 demand

A

nitroglycerin

44
Q

Which of the following drugs inhibits late inward sodium current in ischemic
myocardium

A

ranolazine

45
Q

Which of the following ischemic heart diseases is due to a fixed blockage and not plaque
rupture

A

Stable ischemic heart disease

🡨 the rest were acute coronary syndrome, which is due to plaque rupture

Pharmo Test Two Old Test Review (8 decks)

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