Drugs affecting RAAS Flashcards
What are the adverse effects of ACE Inhibitors?
COUGH is a main one
reactions related to vasodilation/alterations in blood flow
reflex tachycardia, hypotension, renal insufficiency, dizziness, fatigue, erectile dysfunction, pancytopenia, GI irritation, rash, hyperkalemia, cough
Action
ACE Inhibitors
Angiotensin converting enzyme
Blocks ACE from converting angiotensin I to Angiotensin II in the RAAS.
Blocks aldosterone leading to vasodilation, sodium, and water excretion and small increase in serum potassium.
What is ACE Inhibitor used for (indication)?
HTN
CHF
Left ventricular dysfunction
Diabetic nephropathy prevention
What are some examples of ACE inhibitor meds?
benazepPRIL captoPRIL enalaPRIL lisinoPRIL ramiPRIL
What has drug-drug interaction with an ACE inhibitor?
Allopurinol
NSAIDS
Other meds affecting the RAAS
Who is ACE inhibitor contraindicated for?
IF you have: allergy to one of these meds impaired renal function BLACK BOX WARNING- PREGNANCY caution: acute/unstable CHF
Nursing Info for ACE Inhibitors
Labs= CBC
Administer on empty stomach
Patient teaching regarding COUGH
Action
Angiotensin II Receptor Blockers (ARB’s)
Antagonist
- blocks angiotensin II from binding with the receptors on the vascular smooth muscle and in the adrenal cortex
- prevents vasoconstriction
- prevents release of aldosterone
What are angiotensin II receptors?
specific receptors found in the blood vessels and in the adrenal gland that react with angiotensin II to cause vasoconstriction and release of aldosterone
(opposite of angiotension II receptor blockers)
Medication Examples of ARB’s
Candesartan Irbesartan Losartan Olmesartan Telmisartan Valsartan take these with or without meds BLACK BOX WARNING for pregnancy
Indications
What is Angiotensin II receptor Blockers (ARB’s) used for?
HTN
CHF
Diabetic Nephropathy prevention
ARB’s -how they work
ARB’s cause vasodilation and help lower BP
Action
Renin Inhibitor
Blocks the 1st step in the renin angiotensin system
Indications / Medication example- (only 1)
Renin Inhibitor
Hypertension
Aliskiren- Tekturna
Drug drug interaction
Renin Inhibitor
Don’t take with Furosemide or
with any other drugs affecting the RAAS (ARB’s/ACE)
