hypersensitivity pneumonitis Flashcards
1
Q
what proportion of patients have unclear aetiology?
A
20-60%
2
Q
what is the pathophysiology of hypersensitivity pneumonitis?
A
Inflammation in initial stages
May fibrose later on
Type 3 hypersensitivity reaction - immune complexes mediated, prior sensitisation needed
IgG antibodies produced by lymphocytes, retain immune memory
Repeated exposure leads physiological decline
3
Q
what typically causes hypersensitivity pneumonitis?
A
Ask about pets, pigeons, mould, job, avian proteins from bird dropping
4
Q
how is hypersensitivity pneumonitis managed?
A
remove trigger
steroids
