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STEP1 > Micro DRUGS > Flashcards

Micro DRUGS Flashcards

1
Q

River blindness - Onchocerca volvulus

A

Ivermectin->Binds to glutamate-gated chloride channels, causing hyperpolarization.
2dar effects-> Skin pruritus

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2
Q

Wucheria

Loa loa

A

Diethylcarbamazine -> Inhibits arachidonic acid metabolism

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3
Q

African sleeping sickness - Trypanosoma Gambisiense and T. Rhodenisiense

A

Suramin and Melarsaprol

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4
Q

Chagas Disease - Trypanosoma cruzi

A

Nifurtimox

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5
Q

Leishmaniasis - L. Donovani

A

Sodium Stibogluconate

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6
Q

Toxoplasmosis

A

Sulfadiazine and Pyramethamine

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7
Q

Babesiosis - Babesia M.

A

Quinidine

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8
Q

Flask-shaped liver abscesses - Entamoeba H.

A

Iodoquinol (and Metronidazole)

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9
Q

Manejo de post expo de rabia

A

1) Px vacunado-> 2 vacc + limpiar herida con yodo.

2) pz nunca vacunado-> 4 vacc +limpiar herida con yodo + inmunoglobilina anti-rapica

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10
Q

Manejo Pre-eposure rabies-> (4)

A

1) Traveling to country with widespread rabies.
2) activity will bring you into contact with domestic/wild animales (vet,biologist,agricultural specialist)
3) Remote areas where medical care is limited or deleyed (hiking)
4) Staying >1m in a area where dog rabies is common.

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11
Q

Gram + bacilli,anaerobic,spore forming

A

Clostridium

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12
Q

Virulence factors-> C. Botulinum

A 
#1 Botulinum toxin-> Protease that cleaves SNARE proteins-> preventing the release of Ach.
Heat labile
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13
Q 
Descending flaccid paralysis
Constipation
Mouth dryness
Dysarthria / Dysphagia
Diplopia
A

Clostridium Botulinum

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14
Q

neonatal hypotonia

A

Floppy baby syndrome

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15
Q

Clostridium Botulinum types

3

A
  1. Infant botulism-> spore ingestion (honey or soil)
  2. woud botulism->intravenous drug abuse
  3. Foodborne botulism->pre formed toxin -> canned foods
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16
Q

Tx Botulism

A
  1. Infant botulism->botulism immune globin
  2. woud botulism->botulism immune globin + wound debridement
  3. Foodborne botulism->antitoxin and medication-induced bower emptying
17
Q

Virulence factors-> c tetani

A
  • Tetanospasmin: protease that binds to PNS and travels retrograde to Renshaw cells in the CNS
  • Tetanolysin-> hemolitic and carditoxic.
18
Q

Bloqueo de SNARE (synaptobrevin) por lo que no se activa la accion de la glicina y GABA

A

fisiopatologia de Tetanous

19
Q

Virulence factors-> C perfringens

A

Alpha toxin -> Lecithinase (phospolipase) destroy phospholipids

STEP1 (19 decks)

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