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Micro Unit 2 > Antimicrobial drugs > Flashcards

Antimicrobial drugs Flashcards

1
Q

Staphylococcus aureus gram stain

A

Gram positive cocci

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2
Q

Staphylococcus aureus

A

Normal flora of Skin, nose, throat

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3
Q

Staphylococcus aureus cause?

A

Disease some resistant to methicillin Methicillin(resistant Staphylococcus aureus (MRSA)

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4
Q

Specific type of staph that is resistant to beta-lactams

A

MRSA

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5
Q

Two type of MRSA

A

Health-associated MRSA

Community-associated MRSA

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6
Q

Healthcare associated MRSA

A

Resistant to many different chemotherapeutic agents

Used to be more prevalent

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7
Q

Community-associated MRSA

A

Resistant to fewer chemotherapeutic agents

Rise in # of cases

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8
Q

MRSA causes

A

Skin infections

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9
Q

MRSA transmission

A

Direct contact

Fomites

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10
Q

MRSA Signs/Symptoms

A

Red bump on skin (may be swollen/painful, warm, filled with pus)
Fever

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11
Q

MRSA Dx

A

Culture

Nucleic acid identification

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12
Q

MRSA Tx

A

Vancomycin?
VRSA
Glycylcyclines?
Should do susceptibility testing first

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13
Q

Pseudomonas gram stain

A

Gram-negative rod

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14
Q

Pseudomonas

A

Can utilize unusual carbon sources  Can grow in soap/antiseptics  Resistant to many chemotherapeutic agents
Main mechanism of resistance = efflux pumps Most clinically relevant: Pseudomonas aeruginosa

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15
Q

Pseudomonas aeruginosa produce?

A

blue/green pigment
Common hospital-acquired infection
Commonly infects burns/wounds

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16
Q

Pseudomonas aeruginosa causes

A 
Wound/burn infections
Bacteremia
Ear infections
UTIs
Respiratory infections
Dermatitis
17
Q

Pseudomonas aeruginosa Pathogenesis

A

Produces exoenzymes: cleave collagen and interfere with fibrin formation
Contains LPS—endotoxin—released when cell is
lysed -> severe drop in blood pressure ->
blood/oxygen can’t reach organs
Produces Toxin A: inhibits protein synthesis -> cell death
Produces hemolysins: lyse RBCs

18
Q

Pseudomonas aeruginosa Diagnosis

A

Culture

19
Q

Pseudomonas aeruginosa Treatment

A 
Carbenicillin?
Carbapenems?
Gentamicin?
Polymyxin E?
Should do susceptibility testing to confirm

Micro Unit 2 (7 decks)

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