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1. IMMS Flashcards > Link Reaction & Krebs Cycle > Flashcards

Link Reaction & Krebs Cycle Flashcards

1
Q

Where do these cycles take place?

A

In the mitochondrial matrix

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2
Q

In what type of resp do these occur?

A

Only aerobic respiration

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3
Q

What is the equation for the link reaction?

A

Pyruvate ———> acetyl CoA + CO2
Coenzyme A
NAD+ —-> NADH + H+

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4
Q

Acetyl CoA binds with?

What does it produce?

A

Citrate synthase

Citrate

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5
Q

Citrate —-> ?

Enzyme?

A

Citrate —-> isocitrate

Aconitase

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6
Q

Isocitrate —-> ?

Enzymes?

A

Isocitrate —-> alpha ketoglutarate

Isocitrate dehydrogenase
NAD+ —-> NADH + H+
CO2

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7
Q

Alpha ketoglutarate —-> ?

Enzymes?

A

Alpha ketoglutarate —-> succinyl coenzyme A

Alpha ketoglutarate dehydrogenase

NAD+ —-> NADH + H+
CO2

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8
Q

succinyl coenzyme A —-> ?

Enzymes?

A

succinyl coenzyme A —-> succinate

Succinyl CoA

GDP—-> GTP

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9
Q

Succinate —-> ?

Enzymes?

A

Succinate —-> Fumarate

Succinate dehydrogenase

FAD —-> FADH2

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10
Q

Fumarate —-> ?

A

Fumarate —-> Malate

Fumarate hydratase

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11
Q

Malate —->?

Enzymes?

A

Malate —-> oxaloacetate
Malate dehydrogenase
NAD+ —-> NADH

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12
Q

What is the acronym for Krebs cycle?

A

Can I keep some succinate for my oxaloacetate?

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13
Q

What are the 3 enzymes used for regulation of the Krebs cycle?

A

Citrate synthase
Isocitrate dehydrogenase
Alpha ketoglutarate dehydrogenase

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14
Q

How is citrate synthase a rate limiting step?

A 
Allosterically inhibited (away from active site) by ATP and NADH
Competitively inhibited by succinyl CoA
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15
Q

How is isocitrate dehydrogenase the rate limiting step?

A

Main one

Higher oxidative phosphorylation demand = faster the Krebs cycle

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16
Q

How is alpha ketoglutarate dehydrogenase a rate limiting step?

A

Affected by its products
Succinyl CoA + NADH
Higher products = less enzyme

17
Q

What is the aim of the Krebs cycle?

A

Produce NADH and FADH for oxidative phosphorylation

18
Q

Acetyl CoA can enter the Krebs cycle from which other process?

A

Beta oxidation of fatty acids

19
Q

Where can alpha ketoglutarate also come from?

A

Oxidative deamination

1. IMMS Flashcards (14 decks)

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