1.13 Glycogen metabolism Flashcards
(13 cards)
Where is glycogen stored?
Liver and skeletal muscle
What is the bank account of sugars?
Glycogen
What does the liver use glycogen for?
To maintain blood glucose levels
How are the glucose molecules connected within glycogen?
by alpha 1-4 and alpha 1-6 bonds
What are the reducing and non reducing carbons of glycogen?
C1 is reducing and C4 is the non-reducing (where removal of terminal glucose occurs)
In glycogen breakdown G-1-P is converted to ________. While in glycogen synthesis G-6-P is converted to ________.
G-6-P; G-1-P
How does UDP-Glucose form from UTP and G-1-P?
By catalysis from UDP-glucose pyrophosphorylase
What does glycogenin do?
Initiates glycogen synthesis and acts as a precursor enzyme to cleave UDP
When is glycogen synthase most active?
When it is NOT phosphorylated (A version)
What happens to glycogen synthase when it gets phosphorylated?
It becomes less active (the B version)
When is Glycogen Phosphorylase active? When inactive?
When phophorylated (version A). When dephosphorylated (version B).
What is the defective enzyme in Von Gierke’s disease?
G-6-Phosphatase in liver
What is the effect of having a defective G-6-Phosphatase in the liver?
Liver cannot release free glucose into the blood. Liver enlarges (hepatomegaly) and hypoglycemia insues
