Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Clinical Pharmacology > Anticoagulants > Flashcards

Anticoagulants Flashcards

1
Q

Unfractionated heparin MoA

A

Forms complex with AT III
ATIII and thrombin complex both individually bind to heparin, and inhibit factor IIa (thrombin)
only AT III required to bind to Xa (not heparin)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

LMWH examples

A

Dalteparin, Enoxaparin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

LMWH MoA

A

Inhibits factor Xa by enhancing AT III activity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Differences in dose response between UFH and LMWH

A

LMWH dose is predictable as it doesnt bind to endothelial cells etc

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

UFH use

A

Moderate renal impairement

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

LMWH use

A

prophylaxis of thromboemobolism
pregnancy- does not cross placenta
ACS

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Monitoring of heparin

A

LMWH- little monitoring

aPPT required for UFH

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Heparin reversal agent

A

Protamine sulphate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Heparin ADR

A

Bleeding
heparin induced thrombocytoenia
hyperkalaemia (aldosterone inhibited)
Osteoporosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Heparin DDI

A

ACE inhibitors, Amiloride (diuretic), spironolactone (causing hyperkalaemia)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Warfarin MoA

A

Inhibits Vitamin K epoxide reductase- inhibits reduction of vit K into active form
Inhibits activation of Vit K dependent clotting factors- 2,7,9 10

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Warfarin uses- oral

A

Severe renal impairement
Venous thromboemobilism
Atrial fibrillation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Warfarin in pregnancy

A

contra-indicated - crosses placenta
teratogenic in 1st semester
haemorrhagic in 3rd semester

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Warfarin DDIs

A

CYP2C9 polymorphisms
Antibiotics reduce GI vit K - increase INR
NSAIDs decrese GI vit K absorption - increase INR
CYP inducers accelerate Warfarin metabolsim - decrease INR
Metronidazole inhibits CYP2C9- increase INR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Warfarin monitoring

A

Prothrombin time- Factor VII most sensitive to vit K deficiency
Use INR to compare

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

DOAC examples

A

Apixiban- oral

17
Q

DOAC MoA

A

direct inhibition of free Xa and Xa bound with AT III

18
Q

DOAC DDIs

A

CYP inhibitors and inducers affect plasma conc

Clinical Pharmacology (18 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions