Ebola

Question 1

How is Ebola transmitted?

Answer 1

Bodily fluids of infected person including semen

Transplacental

Question 2

Where do you find Ebola virus?

Answer 2

West and central Africa

Question 3

What is pathophysiology of Ebola virus?

Answer 3

Replicates in macrophages
Spreads to LNs
Viraemia to liver and spleen
Inflammatory response

Question 4

What are the features of Ebola virus?

Answer 4

Flu like symptoms
Bleeding in 20%
D+V
Rash
Liver and kidney impairment
HA/confusion 
Multi organ failure

Question 5

How do you diagnose Ebola?

Answer 5

RT-PCR
ELISA
NAT/RDTs

Question 6

How do you treat Ebola?

Answer 6

Supportive

Some experimental MABs and specific antivirals

Question 7

What are the complications of Ebola?

Answer 7

Can have prolonged infection in CNS, semen, breast milk and aqueous humour
Sequelae: HA, visual disturbance, dizziness, reduced appetite
Socioeconomic!

Question 8

How do you prevent ebola?

Answer 8

Education: bushmeat, dead animals
Ervebo vaccine
Isolation
Safe burial or cremation of bodies
Makes safe sex for 1yr post infection or 2 negative semen samples

Question 9

What infection prevention control measures should occur when dealing with VHF?

Answer 9

Isolate Pt
Two areas with triage system: Pts meeting case definition, Pts with confirmed disease
PPE: 2xgloves, coverall, apron, FFP3, eyewear, hood and boots
Supervised donning and doffing
Buddy
Safe sharps use
Incinerate or safely bury clinical waste
Trace contacts of patients for last 3 weeks and establish surveillance of them (BD temps)
Provide information for families and the community about prevention and the care Pts are receiving