Viral Hepatitis

Question 1

transmission, incubation and diag of Hep A

Answer 1

faeco-oral
2-6 w incubation
diag = HAV in stool

Question 2

blood findings in acute hep A inf vs if had Hep A vac

Answer 2

recent inf = inc IgM, inc ALT

vac = inc IgM, Inc IgG, normal ALT

Question 3

transmission and incubation of hep B

Answer 3

std/blood/mother-baby

2-6mo incubation

Question 4

chances of developing chronic Hep B from inf

Answer 4

10%

Question 5

what can Hep B cause

Answer 5

inc hepatic fib -> cirrhosis -> HCC

Question 6

what does presence of igM anti HBc indicate

Answer 6

recent/current inf

Question 7

what does the presence of high HBV DNA levels indicate

Answer 7

good indicate for presence of cirrhosis

Question 8

who more commonly gets Hep C and whats its incubation

Answer 8

IVDU/MSM - blood spread

6-8w

Question 9

chance of developing chronic Hep C inf

Answer 9

60%

Question 10

what does high HCV-RNA levels indicate

Answer 10

active inf

Question 11

whats the treatment for Hep C

Answer 11

initially Tx with interferon the combinationof 2 DAA (direct acting antivirals) +/- ribavirin

Question 12

what can be said about the transmission of hep D

Answer 12

req co-hep B inf

Question 13

whats the treatment for Hep D

Answer 13

peg-IFN-a

Question 14

whats the transmission and incubation for Hep E

Answer 14

faeco-oral, 3-8w incubation

Question 15

what are the complications of Hep E

Answer 15

CNS disease, chronic inf,

Question 16

what hep is most dangerous to pregnant women and when

Answer 16

Hep E in 3rd tri -> fulminant liver failure