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haematology > myeloma > Flashcards

myeloma Flashcards

1
Q

what

A

plasma cell proliferation

due to genetic mutations which occur as B Lymphocytes differentiate into mature plasma cells

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2
Q

median age presentation

A

70

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3
Q

CRABBI

A 
hypercalcaemia 
renal disease
anaemia 
bleeding 
bone disease
infection
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4
Q

bloods show

A 
anaemia 
thrombocytopenia
raised urea
raised creatinine 
raised calcium
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5
Q

finding on peripheral blood film

A

rouleaux formation

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6
Q

serum or urine protein electrophoresis shows

A

serum - raised concentrations of monoclonal Ig

urine - bence jomes protein

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7
Q

common x-ray finding

A

rain-drop skull

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8
Q

induction Mx - suitable for autologous SCT

A

bortezomib + dexamethasone

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9
Q

induction Mx - unsuitable for autologous SCT

A

thalidomide + alkylating agent + dexamethasone

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10
Q

Mx - relapse

A

bortezomib monotherapy

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haematology (32 decks)

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