Obstetrics- Prenatal Screening & Fetal testing

Question 1

First trimester combined screening

Answer 1

Sonographic nuchal translucency (NT)
B-HCG
PAPP-A (pregnancy associated protein A)

Question 2

Timing: first trimester combined screening

Answer 2

10-13 wks

Question 3

Quad screen test

Answer 3

HCG
AFP
Estriol
Inhibin A

Question 4

Triple Screen test

Answer 4

HCG
AFP
Estriol

Question 5

Timing: Triple/ Quad screen test

Answer 5

15-20wks

Question 6

Trisomy 21 screening findings

Answer 6

↑HCG
↓PAPP-A
↑Nuchal Fold
↓AFP
↓Estriol
↑Inhibin A

Question 7

Trisomy 18 screening findings

Answer 7

↓HCG
↓↓ PAPP-a
↑ Nucal Translucency 
↓↓AFP
↓↓Estriol 
↓/ normal Inhibin A

Question 8

Trisomy 13 screening findings

Answer 8

↓HCG
↓↓ PAPP-a
↑ Nucal Translucency

Question 9

Molar pregnancy screening findings

Answer 9

↑↑HCG

Question 10

Ectopic pregnancy screening findings

Answer 10

↓HCG
↓AFP
↓ Estriol

Question 11

Neural tube defect/ Abdominal wall defect findings

Answer 11

Normal HCG
↑AFP
Normal Estriol/ Inhibin A

Question 12

causes of Elevated AFP Incorrect gestational age

Answer 12

incorrect gestational age (most common cause)
multiple gestation
Neural tube defect
abdominal wall defect

Question 13

Kleihauer-Betke test

Answer 13

requires in Rh-Negative patients with heavy bleeding during pregnancy to evaluate for fetomaternal hemorrhage that can lead to Rh-alloimmunization

Question 14

Prevention of RH-alloimmunization

Answer 14

Anti-D immunoglobulin (RHoGAM)