Tricyclics Flashcards
1
Q
What was the first antidepressants used for OCD?
A
Tricyclic clomipramine (brand name Anafrani)
2
Q
What do Tricylics do?
A
They block the transporter mechanism that re-absorbs both serotonin and noradrenaline into the pre-synaptic cell after it has been fired
3
Q
What is the benefit of tricyclics?
A
More transmitters are left in the synapse which prolong their activity
4
Q
What is an advantage of tricyclics?
A
they can target more than one neurotransmitter
5
Q
Name a disadvantage of tricylics?
A
The side effects are greater so they are used as a second-line treatment for patients when SSRI’s are not effective
