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Past Paper Qs > Immuno > Flashcards

Immuno Flashcards

1
Q

what cell in inhibited by the presence of MHC1 on cells

A

NK cells

org invades cell - damages MHC1 -> hidden from rest of immune response but attacked by NK cells

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2
Q

what cancer develops in Barrett’s oesophagus

A

Adenocarcinoma

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3
Q

Mechanism in esophagus as a result of GORD (reflux) that results in cancer

A

Metaplasia

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4
Q

what happens to the Body of the stomach in pernicious anaemia

A

atrophic gastritis (weakened stomach lining)

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5
Q

what cancer do you get with H pylori

A

MALT

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6
Q

what cancer do you get in coeliac if you dont follow a gluten free diet

A

lymphoma

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7
Q

Most common breast malig

A

inv ductal carcinoma

DCIS = most common non-invasive

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8
Q

Breast cancer - E cadherin +ve

A

inv ductal carcinoma

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9
Q

Breast C - E cadherin -ve

A

inv lobular carcinoma

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10
Q

Breast fibro-epithelial tumour with abundant stromal elements

A

phyllodes tumour

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11
Q

Low enzyme -> hyperuricaemia/rise in blood uric acid

A

HGPRT (lesch Nyhan syndro)

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12
Q

what enz regulates the rate limiting step in haem biosynthesis

A

ALA Synthase

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13
Q

What enz is raised in mumps

A

Amylase S

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14
Q

which biomarker raised in Rhabdomyolysis

A

Creatine Kinase

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15
Q

raised anti-mitochondrial antibody

A

Primary biliary cirrhosis/cholangitis

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16
Q

raised anti CCP

A

rheumatoid arth

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17
Q

raised anti acetylcholine receptor Ab

A

myasthenia gravis

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18
Q

anti SSB/La Ab

anti-SSA/Ro Ab

A

Sjogrens

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19
Q

raised tissue transglutamase ab

A

coeliac

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20
Q

raised anti endomysial an

A

coeliac

21
Q

anti smooth-muscle Ab

A

AI hep

PSC

22
Q

raised cANCA

A

small vessel vasc - esp Wegener’s Granulomatosis

23
Q

raised pANCA

A

PSC

24
Q

anti-glomerular basement memb ab

A

goodpastures

25
Q

anti IF abs

A

pernicious anaemia

26
Q

anti-microsomal Abs

A

chronic lymphocytic thyroiditis (hashimotos)

27
Q

TSHR Abs

A

Graves

28
Q

Anti Jo-1 Ab

A

polymyositis and dermatomyositis

29
Q

anti Scl70

A

systemic sclerosis

30
Q

ACAs (anti centromere Abs)

A

CREST syndro

31
Q

woman presents with dry eyes and parotid swelling

A

Sjogrens syndro

32
Q

what do you measure to measure progress of SLE

A

C3/C4

anti ds-DNA

33
Q

Hx of multiple staph skin and soft tissue inf

Aspergillus inf

A

chronic granulomatous disease

34
Q

Hx of neutrophilia, absent pus in ulcers + delayed umbilical cord cutting

A

Leukocyte adhesion def 1

35
Q

Kid with recurrent inf, doesnt have any B cells

A

Brutons X linked gammaglobinaemia

36
Q

Kid with inf, +ve nitro blue tetrazolium

A

myeloperoxidase def

37
Q

kid with no CD4+, but CD8+ and B cells present

A

Bare lymphocyte syndro

38
Q

recurring mycobac inf

get TB following BCG vaccine

A

IFN Gamma R def

39
Q

Neck swelling - stained and gives a “starry sky” appearance

A

Burkitt’s Lymphoma

40
Q

Chr mutation (9,22) -> what cancer

A

CML

41
Q

Chr mutation (15,17) -> what cancer

A

AML

42
Q

lrg cells with basophillic cytoplasm and nucelus clock-face chromatin without nuclei
+/- Rouleaux

A

MM

43
Q

tense bulla on flexural surfaces of elderly, T2 hypersensitivity

A

bullous pemphigoid

44
Q

wickham striae in buccal cavity

A

Lichen Planus

45
Q

recurrent inf since birth, neutrophil count normal, nitro blue tetrazolium test - remains colourless

A

CGD

46
Q

haematuria, red and white cell casts, hypertensive, passing urine less

A

nephritic syndro

47
Q

haemoptysis, haematuria, renal F, biopsy shows crescent morphology

A

good pastures syndro

-> rapidly progressing glomeruloneph

48
Q

recurrent chest inf and bouts of diarrhoea

A

selective IgA def

Past Paper Qs (9 decks)

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