14.6 (4.17) Integrative oncology in PM Flashcards

1
Q

What is complementary and alternative medicine (CAM)?

A

Therapies being provided in parallel or as an alternative to mainstream medicine

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2
Q

What is CIM?
How does the oxford text book define CAM vs CIM?

A
  1. Complementary and integrative medicine
  2. Oxford text uses CAM to describe patient-initiated use of complementary medicine

AND

CIM as the use of research-based practices as provided within an integrative context of care

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3
Q

Define integrative oncology

A

The idea and practice of adding complementary and alternative medicine (CAM) approaches to options for cancer patients in previously strictly conventional medical environments

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4
Q
  1. How does integrative oncology (IO) differ from alternative medicine treatments?
  2. How do IO services provide a range of CIM (complementary and integrative medicine) modalities? (Ie who would be involved)
A
  1. Alternative medicine treatments typify what is being practised outside of conventional medicine.

IO services are situated GEOGRAPHICALLY and CONCEPTUALLY within conventional oncology/pall care

  1. Via multidisciplinary teams of CIM-trained physicians (IPs), nurses, paramedical therapists AND non-CIM practitioners (accupuncturists, mind-body, art therapists)
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5
Q

What are complementary and alternative therapies and how do they differ from one another

A

(this question/definitions are from 5th edition)

alternative therapies - promoted for use instead of standard tx (despite no alternatives existing), schemes

complementary therapies - used to control symptoms (eg pain), enhance wellbeing (physical, mental, spiritual), optimize QOL for patients and families

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6
Q
  1. List 2 ways in which integrative oncology (IO) is similar to palliative care
  2. What is the goal of IO?
  3. How do the 2 fields work together?
A

1.
a) patient-centered
b) holistic biopsychosocialspiritual perspective

  1. to provide individualized CIM treatment plan which will help reduce suffering and improve QOL
  2. Varies between oncology centres - some provide each domain separately, others collaborate
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7
Q

List five modalities of complementary therapy that are acceptable in PC

A
1. acupuncture
2. accupressure
3. manual and movement therapies (reflexology, qigong)
4. Mind body techniques
5. spiritual approaches (guided imagery, yoga, meditation)
6. Music 
7. fitness/physical activity
8. nutrition
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8
Q
  1. What is the evidence for CIM (complementary and integrative medicine) in cancer settings
  2. List 5 scenarios in which CIM could be helpful*
A
  1. Large body of evidence supporting effectiveness and safety of CIM for relief of symptoms and improving QOL
  2. i) patients for whom conventional care is not enough or too difficult
    ii) supportive care in neo-adjuvant/adjuvant settings
    iii) throughout survivorship
    iv) metastatic cancer/end of life care
    v) “fill the gap” in patients with suboptimal response to pall care
    vi) patients unwilling to adhere to conventional pall care drugs/psych-onc interventions
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9
Q

List 3 different types of CAM popular in 3 different areas of the world

A
  1. US/West - dietary supplement use
  2. Central Europe - anthroposophic + homeopathy
  3. Asia/Middle East - traditional herbal medicine
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10
Q

List 3 groups of people that may be more likely to use CAM

A
  1. In the U.S. , Caucausian patients more likely than non-white patients
  2. Patients with more advanced disease or worse QOL
  3. Refugee/immigrants from developing countries (rural/low SES) where herbal medicine is also popular
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11
Q

List 4 safety-related concerns with use of non-conventional medicine by oncology patients

A
  1. When treatment claims to be alternative to conventional care but not established as such
  2. Extreme dietary changes
  3. High expense leading to debt
  4. False belief that “natural” non-conventional treatments are without risk
  5. Negative effect on conventional oncology Rx or drug-herb interactions

Drug drug interactions, benefits, risks, cost

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12
Q

Tension may rise between patients and conventional medicine HCP’s (underlined by principle of autonomy, true informed consent and paternalism).

List 3 patient-centered ways in which HCP’s can approach discussions about safety-related concerns

A
  1. Respect patient autonomy, including wish to seek out alternative options
  2. Try to understand patient’s decision within their health-belief models (rather than the herb etc)
  3. Understand the expectations & goals in the search for the alternative

Trust + what when where who + why + how

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13
Q

List 4 steps to establishing a patient-centered dialogue on the use of CAM during cancer care

A

Table 14.6.1:

  1. Establish Trust
    Respectful, non-judgemental, emphasize pt rights
  2. Discuss present CAM Use
    (which products, who is advising use, document)
  3. Explore patient expectations and concerns
    (what are expectations, “favourable” response)
  4. Discuss issues of safety re: CAM + supplement use
    (concerns, pt idea of “harm”, does pt want advice? IP consult?)

Trust, what/when/where/who + why + how

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14
Q

List 4 goals of integrative oncology

A
  1. Treat symptoms and improve QOL
  2. Increase patient adherence to planned conventional oncology treatments
  3. Provide expertise of IP to minimize herb-drug interactions
  4. Reduce need/costs of symptomatic pharmacotherapy

*IP = integrative physician

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15
Q

You are following a patient in the community as a PC provider. The patient has met lung can and is scheduled to receive pall XRT to the chest wall.

The pt’s daughter pulls you aside at the visit and tells you the patient is taking supplements that have a high dose of cancer fighting enzymes. She tells you her mother is not health literate and wants to know some things to she should tell her mother to get her to avoid using these potentially harmful pills.

What are three important issues you can discuss with the patient and daughter re these supplements

A

herb drug interactions may be underreported

can interfere with prescription drug metabolism through P450 enzyme/glycoprotein inhibition

may increase bleeding when taken with anticoagulants

cause unwanted interactions with anesthetics

increase skin toxicity and decrease efficacy radiation

FS:
- drug interactions
- radiation interactions
- side effects

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16
Q
  1. List 2 ways in which botanicals can alter the pharmacodynamics of conventional drugs.
A
  1. Induction/inhibition of enyzmes in cytochrome P450 system OR
  2. transport proteins such as P-glycoprotein
17
Q

List 3 ways in which herbal supplements can negatively impact cancer care

A
  1. Herb-drug interactions that can affect treatment of malignant process
  2. Negative effect on other drugs (analgesics, anticoagulants)
  3. Affect safety of cancer surgery (ie. increase risk of bleeding, interact with anesthetics, etc)
18
Q

List evidence-based potential uses for CIM for the following symptoms (Table 14.6.2):

  1. CINV
  2. Oral mucositis
  3. Cancer related fatigue
  4. Hematological toxicities
  5. Anxiety/depressive mood
  6. Dyspnea
  7. Hot flashes
  8. Pain
  9. Xerostomia
  10. Insomnia/sleep quality
A

Table 14.6.2 (**note oxford does not give grade level of evidence, not clear how strong)

  1. CINV: ginger, acupuncture
  2. Oral mucositis: carob, chamomile, mint, tumeric, honey
  3. CRF (cancer related fatigue):
    ginseng, astralagus, mistletoe
    mind-body, acupuncture, acupressure
  4. Hematological toxicities: botanical LCS101 reduces chemo induced cytopenias
  5. Anxiety/depression: meditation, relaxation, yoga, massage, music therapy, Qigong, aromatherapy, acupuncture
  6. Dyspnea: reflexology
  7. Hot flashes: acupuncture
    mind body: hypnosis, yoga
  8. Pain:
    mind-body: massage
    acupuncture
  9. Xerostomia: aromatherapy, acupuncture
  10. Insomnia/sleep quality:
    Herb - valerian
    Mind-body: MBSR, Tibetan yoga, Qigong/tai chi
    Accupressure

Exercise , massage, acupuncture, mind body

19
Q

Give 5 examples of evidence-based MIND BODY therapies for improving patient symptoms/well being

A
  1. MBSR (mindfulness based stress reduction) for anxiety/sleep/fatigue (grade A level evidence)
  2. Meditation for anxiety
  3. Relaxation therapy for depression/mood disorders
  4. Yoga for anxiety/mood (Grade B) and fatigue/insomnia
  5. Hypnotherapy for N/V, periprocedural pain/anxiety, hot flashes,
    and with CBT, helps cancer related fatigue
  6. Visualization and progressive relaxation - decrease pain
  7. Guided imagery: Helped with body-image issues in breast cancer patients
  8. Aromatherapy - depression/anxiety, salivary gland function
  9. Qigong, tai chi - sleep, anxiety, depression, cancer-related fatigue
  10. Massage/touch therapies - pain, mood
    Reflexology - dyspnea
    Reiki - comfort/well-being
20
Q
  1. What are the local and central physiological effects of accupuncture?
  2. List 4 symptom benefits of accupuncture shown in clinical research
A
  1. Local - cytokine and endorphin release
    Central - endorphine, ACTH, serotonin release
  2. i) as effective as ondansetron for immediate onset CINV (<24hrs)
    ii) superior for delayed CINV (4-5 days)
    with lower constipation/insomnia side effects

iii) cancer related fatigue in breast cancer
iv) aromatase inhibitor induced joint pain/stiffness

v) hot flashes in breast cancer
vi) post-mastectomy pain, nausea, anxiety
vii) lymphedema in breast cancer
viii) xerostomia in H&N cancers

Nausea, pain, anxiety, fatigue, hot flashes, xerostomia

21
Q
  1. List 2 symptom benefits of music therapy shown in RCTs
  2. What is the goal of art therapy +
    List 2 QOL benefits of art therapy
A
  1. anxiety, pain, fatigue

may have peri-op benefit:
- anxiety/depression in ASCT patients
- pain/anxiety in breast cancer patients

  1. To use the creative process to improve physical, mental, and emotional well being.

Evidence that it helps anxiety/depression, coping, stress/anger

FS:
Anxiety
Depression

22
Q

A patient that you see in clinic with a recent dx of locally advanced ER+ breast ca tells you she has ordered a high vitamin content juice recipe book that is designed to tx cancer. What are three risks of pursuing this type of therapy?

A

not viable substitues for anticancer tx - miss standard tx and get disease progression

interact with standard tx

cause symptoms (pain, nausea)

23
Q

A patient you are seeing on the PCU with met lung ca tells you he wont go to hospice after dc because he will be pursuing high dose vitamin injections and vibrational healing. Onc has given <3months, and ECOG 3. What are two reasons he may be pursuing these therapies?

A

attempt to do something more

unmet physical, emotional, spiritual, psychological needs that require attention

24
Q

A patient on the PCU has read about some complementary therapies such as massage and hypnosis and wants to know what types of benefits she might see from them.

List 3 possible benefits from complementary therapies

A

hypnotherapy - reduce nausea/vomiting, procedural anxiety, acute or chronic pain in children and adults

massage - helps reduce pain, anxiety, depression, physical discomfort, improves mood

FS
- reduce symptoms
- improve well-being (physical, mental, spiritual)
- improve QOL