Nephritic Syndrome Flashcards
Acute onset of
Gross hematuria
Mild to moderate proteinuria
Hypertension
Inflammatory changes disease leading to nephritic syndrome
Acute diffuse proliferative glomerulonephritis Rapidly progressive (crescent is ) glomerulonephritis
Acute diffuse proliferative glomerulonephritis etiology
Group A beta hemolytic strep
Staph
Pneumococcus
Pathogenesis Acute diffuse proliferative glomerulonephritis
Planted circulating immune complex in situ rxn in glomeruli
Clinical presentation Acute diffuse proliferative glomerulonephritis
Strep sore throat Malaise Fever Nausea Hematuria Hypertension
Lab findings
Red cell in urine Red cell cast in urine High blood urea , creatinine , also titre Low complement Cryoglobulins presence
Acute diffuse proliferative glomerulonephritis immunology
IgG
IgM
C3
Acute diffuse proliferative glomerulonephritis histo
Acute diffuse proliferative glomerulonephritis prognosis
Good - more than 95% recover in children
No so good in adults. - 60% in adults recovery
Complications of Acute diffuse proliferative glomerulonephritis
RPGN
Slow glomeruli nephritis
RPGN type 1 cause
Unknown but associated to good pasture syndrome
Récurrence of IGA nephropahty after renal transplant
60%
Only type of neprhtic syndrome with alternate complement activation
IgA nephropathy
Which glomerular disease wont progress to chronic cglomeruilonephoris
Minimal change in children
Grosss morphology chronic glomeruli;’,d’e,
Glomeruli collapse converted into acellular hyalinized masses
Ceasing of glomerular function
Atrophy and shrinking of tubules
Cortex thinning, fibrous tissue replacement
Symmetrically contracted kidneys due to fibrous tissue contraction
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