Indications

Question 1

Tamoxifen

Answer 1

1) Treatment of ER positive breast cancer pre- and post-menopause. If early prevents recurrence
2) Treatment of ER positive breast cancer in men
3) Treatment of anovulatory infertility
4) Prevention of breast cancer in high risk individuals

Question 2

Letrozole

Answer 2

1) First line for ER positive metastatic cancer in post-menopausal women
2) Adjuvant treatment for ER positive early cancer in post-menopausal treatment
3) Adjuvant treatment with LHRH analogues in high risk pre-menopausal women
4) Neo-adjuvant treatment in ER positive post-menopausal women

Question 3

Exemestane

Answer 3

1) Adjuvant treatment of ER positive early breast cancer in post-menopausal women following tamoxifen therapy (2-3 years)
2) Advanced breast cancer in post-menopausal women in whom anti-oestrogens have failed

Question 4

Goserelin

Answer 4

1) Prostate cancer
a) Neoadjuvant
b) Adjuvant
c) Metastatic setting

2) Breast cancer
a) Adjuvant in pre-menopausal women
b) Advanced breast cancer

3) Gynaecology
a) Endometriosis
b) Pre-op for fibroids
c) Fertility treatments

Question 5

Trastuzumab

Answer 5

1) Adjuvant/ Neo-adjuvant for early breast cancers over-expressing HER2
2) Metastatic HER2 positive breast cancer
3) Metastatic HER2 positive gastric cancer

Question 6

Imatinib

Answer 6

1) Treatment of c-kit positive inoperable or metastatic gastro-intestinal stromal tumours
2) Adjuvant treatment for high risk gastro-intestinal stromal tumours
3) Treatment of CML
4) Treatment of ALL

Question 7

Rituximab

Answer 7

1) Relapsed/ refractory CLL
2) Diffuse large B cell lymphoma
3) Rheumatoid arthritis

Question 8

Capecitabine

Answer 8

1) Adjuvant in metastatic colorectal cancer
2) In combination with platinum chemotherapy in advanced gastric cancer
3) Locally advanced/ metastatic breast cancer