Gyne Flashcards

1
Q

LN drainage for

  1. cervix
  2. endo
  3. vagina
  4. ovaries
  5. vulva
A
  1. parametrial, paracervical, obturator
  2. parametrial and obturator
  3. upper and middle obturator
  4. bilaterally along with ovarian blood vessels to PA nodes
  5. superficial inguinal–>deep femoral–>pelvis
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2
Q

Metastasis for

  1. cervix
  2. endo
  3. vagina
  4. ovaries
  5. vulva
A
  1. lungs, liver, bone
  2. lungs, liver, bone
  3. lung, liver
  4. liver, lung
  5. contralateral inguinal and pelvic LN
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3
Q

S&S

  1. cervix
  2. endo
  3. vagina
  4. ovaries
  5. vulva
A
  1. often found in screening. late stage presents with abnormal vaginal bleeding
    (pelvic exam=staging)
  2. Vaginal bleeding. 10-15% of all post-menopausal vaginal bleeding is cancer related
  3. asymptomatic–>abnormal vaginal bleeding (dysfunctional or post-coital)
  4. No specific signs or symptoms
    -have to grow large before seeing S&S
    -abdominal pain +/or pelvic pain
  5. MC presenting location–>labia
    pruritis
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4
Q

Epi/Eti

  1. cervix
  2. endo
  3. vagina
  4. ovaries
  5. vulva
A
  1. HPV(47)
  2. 4th most common cancer diagnosed in women (58)
    cumulative unopposed estrogen exposure
  3. Rare-HPV- history of VAIN
  4. 4-5th most common female cancer
    age and family history
    BRCA 1 40% risk
    BRCA 2 18% risk
  5. 3-5% of all gyne cancers
    long history of local irritation
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5
Q

Prognostic indicators

  1. cervix
  2. endo
  3. vagina
  4. ovaries
  5. vulva
A
  1. nodal invasion
  2. stage
  3. stage and size
  4. tumour size and volume post-op
  5. size of lesion and depth of invasion
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6
Q

pathology

  1. cervix
  2. endo
  3. vagina
  4. ovaries
  5. vulva
A
  1. SCC
  2. Endometroid and adenocarcinoma
  3. Epithelial tumours
    -SCC 65-85%
    -Adeno 5-10%
  4. Epithelial (90%)
    subtype-serousa and stromal
  5. SCC 90%
    adeno 10%
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7
Q

Disease management Cervix

A

TAH +/- BSO- medically operable pts early stage
(IAI, IA2, IBI, IIA) followed by RT

Node positive or high risk will receive chemo (IIB or higher)

Typically combines EBRT + brachy (stage IB2/IIB)

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8
Q

Cervix dose

A

Brachy only: 45-50Gy HDR

T1N1M0 IBI
-EBRT 5040/28 pelvis
-HDR 2800/4
concurrent cisplatin (since positive node)

If nodes NOT positive T1N0M0, same disease may have TAH
-EBRT 4500/25 pelvic
-HDR 2800/4
NO chemo

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9
Q

Disease management for endometrium

A

Sx:
Stage IA Grade I or II= TAH alone
Stage III= sx + adj therapy
Stage IV= may or may not have TAH-BSO w/ other therapies

Chemo is always adj never alone for stage III & IV

RT is rarely used as a sole modality
post-op RT w/combo EBRT + HDR

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10
Q

Differences between Cervix and endometrium

  1. sx
  2. chemo
  3. RT
  4. dose for HDR
A
  1. Cervix: Stage IAI, IA2, IBI, IIA= TAH+/-BSO followed by RT
    Endo: Stage IA or Grade I or II= TAH alone
  2. Cervix: Node positive or stage IIB or higher
    Endo: Stage III-IV
  3. Cervix: combines EBRT + brachy
    Stage IB2/IIB
  4. Cervix 2800/4
    endo: 2100/3
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11
Q

Endometrium Dose

A

Stage IA grade 1 or 2
-potential no RT post-op

Stage IA grade 3 or Stage IB grade 1 or 2

  • post-op brachy
  • dose given with HDR varies
  • 2100/3fx

Stage IB G3, Stage II-IV
-EBRT + HDR 45-50.4Gy pelvis + brachy

Stage III+IV: RT primary

  • low risk-brachy and EBRT
  • high risk- pelvic, abdo EBRT and brachy and chemo

EBRT 50 HDR 21

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12
Q
  1. Vagina dose

2. Ovaries dose

A
  1. 70-85Gy EBRT + brachy
    45GY EBRT
  2. Abdominal dose of 2250/18 (125/fx)

Pelvic field boost: 45-50Gy

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13
Q

Vulva dose

A

50Gy for subclinical disease
boost 10-15Gy reduced fields

Pre-op RT:
-Chemo RT- 45-50Gy

Medically inoperable:
small superficial lesions; 60-65Gy RT alone
large tumours: primary RT reduced fields to 70Gy

boost; 6-9MeV or 4-6MV

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14
Q

Field borders Cervix

A
Sup: L5
Inf: bottom of obturator foramen 
Lat: 2cm past pelvic brim (4cm below disease)
Ant: pubic symphasis
post: includes S3/4

if PA nodes involved sup border goes to L2 or if PA nodes involved T12

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15
Q

Field borders Endometrium

A

Sup: L5
inf: upper 1/2 of vagina (bottom of obturator foramen)
lat: 2cm past pelvic brim (ext iliac nodes)
ant: pubic symphysis
Post: 2/3 of rectum S3

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16
Q

Field borders vagina

A
Entire vagina
Sup: L5/S1 for positive pelvic nodes
lat: 2cm past pelvic brim
ant: pubic symphysis
post: 2/3 rectum (S2/3)
17
Q

Ovaries Tx border

A

sup: 2cm sup of diaphragm
inf: bottom of Obturator foramen
lat: 2cm beyond lat peritoneum–>epithelial
dysgermionia–>hockey stick