ART

Question 1

List all the classes of ART

Answer 1

1. Nucleoside/Nucleotide reverse transcriptase inhibitors
2. Non Nucleoside/Nucleotide Reverse transcriptase inhibitors
3. Protease inhibitors
4. Protease inhibitors boosters
5. Integrase strand transfer inhibitors
   6 Entry inhibitors- Attachment inhibitors
   Fusion inhibitors
   Chemokine receptor antagonist

Question 2

List 5 examples each of each class of ART

Answer 2

1. NRTI- TDF, TAF, Lamivudine, Entricitabine, Zidovudine (AZT, ZDV, stavudine(d4T)
2. NNRTI - Nevirapine, Efavirenz, Rilpivirine, Dalpivirine, Etravirine
3. Protease inhibitors- Lopinavir, Atazanavir (ATV), Indinavir, Fosamprenavir, saquinavir
4. Protease inhibitors boosters- Ritonavir, Cobicistat
5. Integrase strand transfer inhibitors- Dolutegravir, Cabotegravur, Raltegravir, Elvitegravir

6 Entry inhibitors-
Attachment inhibitors - anti CD4 adnectin, Fostemsavir, Ibalizumab

Fusion inhibitors - anti GP41 adnectin, Enfurvitide, Combinectin

Chemokine receptor antagonist - Maraviroc, Vicroviroc, Cenicriviroc

Question 3

What is IRIS

Answer 3

Immune reconstitution inflammatory syndrome is disease or pathogen specific inflammatory response that occur after initiation of of ARV in treatment naive patients or after re initiation or after a change to a more effective regimen in patients that are yet to achieve viral suppression
Also known as
Immune restoration disease
Can be paradoxical or unmasking
Paradoxical is worsening of previously diagnosed disease condition after ARV initiation
Unmasking is occurrence of previously undiagnosed disease condition after initiation