Imprinting Disorders

Question 1

Prader Willi
-region affected
-presentation
-management

Answer 1

C15, paternal part lost

Constant hunger => obesity, T2D
Intellectual impairment
Narrow forehead, small hands and feet
Short
Infertility

Feeding supervision, exercise
GH
Counselling

Question 2

Angelman
-region affected
-presentation
-management

Answer 2

C15, maternal part lost

Small head, smiley
Intellectual, developmental disability
Ataxia, seizures, tremors

AEDs if needed
Physical therapy for walking