Misc Drugs

Question 1

MOA of Minoxidil

Answer 1

mainly unknown but may activate hair follicle directly, may alter local androgen metabolism

Question 2

adverse effects of Minoxidil

Answer 2

if overused then systemic effects might occur

Question 3

MOA of Finasteride

Answer 3

Testosterone analog; blocks 5-alpha reductase

Question 4

What is the selective effect of finasteride

Answer 4

decreases scalp and serum DHT concentrations

Question 5

adverse effects of finasteride

Answer 5

loss of libido, sexual dysfunction, feminization

Question 6

MOA of eflornithine

Answer 6

decreased ornithine decarboxylase = decreased cell division and differentiation, produces trypanostatic action

Question 7

adverse effects of eflornithine

Answer 7

most are mild skin adverse effects

Question 8

What are fluocinolone, hydroquinone, and tretinoin give for?

Answer 8

temporary relief of facial skin darkening by hormonal changes, pregnancy, OCs or HRT

Question 9

MOA of flucinolone

Answer 9

anti-inflammatory corticosteroid

Question 10

MOA of Hydroquinone

Answer 10

inihibits melanin formation, blocks Tyrosine oxidation to 3,4-DOPA

Question 11

MOA of Tretinoin

Answer 11

modulates skin growth and pigmentation

Question 12

MOA of methoxsalen

Answer 12

topical pigmenting agent activated by UVA exposure. Conjugates and cross-links DNA, cell death. Increased epidermal melanization and thickening of stratum corneum.

Question 13

ADE of methoxsalen?

Answer 13

delayed erythema over several weeks