Antipsychotics Flashcards
Haloperidol
High potency typical antipsychotic
Most likely to cause EPRs & NMS
Improves +ve symptoms
Fluphenazine
High potency Typical AP
Most likely to cause EPRs & NMS
Trifluoperazine
High potency typical AP
most likely to cause EPRs & NMS
Chlorpromazine
Low potency typical AP
Sedation & weight gain
Corneal & lens deposits
Thioridazine
Low potency typical AP
sedation & weight gain
T waves & QTC changes –> Ventricular arrhythmias –> Sudden death
Retinal deposits
Resperidone
Atypical AP
AE = EPR (rare) & Inc prolactin
Quetiapine
Better option = Least likely to have EPRs
Clozapine
Atypical AP Least likely to cause EPRs Can cause Agranulocytosis ONLY used as "Refractory drug" --> CBC monitoring DOC in pregnancy
Aripiprazole
MC used AP
Improves cognitive symptoms
D2 & 5HT1A agonist & 5HT2A antagonist
Olanzapine
Lurasidone
Ziprasidone
Atypical AP
Metabolic AEs > EPR
Dystonia Management
Anticholinergics: Benztropine Benadryl Diphenhydramine Trihexyphenidyl
Akathisia Management
B-blocker + Benzo : Propranolol & Clonazepam
Parkinsonism management
Anti-cholinergic: benztropine Benadryl Diphenhydramine Trihexyphenidyl Amantadine
NO LEVODOPA
Tardive dyskinesia management
Discontinue/ Dec dosage
Clozapine - DOC for these pts.
VMAT Inhibitors : Tetrabenazine & Valbenazine
Benzos
NO ANTICHOLINERGICS
Neuroleptic Malignant Syndrome (NMS) Management
“3Ds”
Discontinue
Dantrolene
Dopamine agonists: Bromocriptine
